Determinants of poorly controlled asthma among asthmatic patients in Jimma University Medical Center, Southwest Ethiopia: a case control study

Zewudie, Ameha; Nigussie, Tadesse; Mamo, Yitagesu; Kumela, Kabaye

doi:10.1186/s13104-019-4571-y

Cited by 15 publications

(39 citation statements)

References 11 publications

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“…This nding is in line with studies conducted in China (33), UK (40), North African and Middle East countries (41), Morocco (35), and Nigeria (18). A previous study conducted at Jimma Medical Center, Ethiopia, also showed that the odds of uncontrolled asthma was about 8.5 times higher among nonadherent patients when compared to the adherent ones (24). The possible explanation for this might be a rapid decline in lung function as a result of non-adherence to medications (42).…”

Section: Discussionsupporting

confidence: 90%

“…The fact that adequate control was not achieved in a signi cant proportion of asthmatic patients, despite the presence of effective medications, emphasizes the importance of identifying the determinants of uncontrolled asthma. Even though a couple of studies have been conducted in Ethiopia (12)(13)(14)24), majority of them were cross-sectional in nature focusing mainly on socio-demographic, clinical, and some behavioral factors. The studies didn't give attention to housing factors, which play a major role in asthma control as the cases pass most of their time in the home environment.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

Geleta

Dadi

Sona

2020

Preprint

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BackgroundUncontrolled asthma is a notorious public health problem throughout the world despite the presence of effective treatments. Characterizing phenotypes of patients with uncontrolled asthma and searching for risk factors of uncontrolled asthma have been suggested as priority research agenda in the prevention of chronic respiratory diseases. This study aimed to identify the determinants of uncontrolled asthma.MethodsInstitution-based case-control study was conducted on asthmatic patients who were on follow-up at chest clinic of Jimma University Medical (JMC) from March to May, 2020. A total of 59 cases and 118 controls were included in the study. Logistic regression was employed to identify determinants of uncontrolled asthma. Adjusted odds ratios (AORs) with their corresponding confidence intervals (CI) were used to assess the strengths of association between uncontrolled asthma and its determinants at p values ≤ 0.05.ResultsAge of the patients [AOR: 2.78; 95% CI: 1.14, 6.81], age of the cases’ residential houses [AOR: 3.65; 95% CI: 1.30, 10.28], presence of pets within the houses [AOR: 2.78; 95% CI: 1.29, 5.96], having rhinitis [AOR: 3.34; 95% CI: 1.17, 9.52], past asthma exacerbation [AOR: 2.38, 95% CI: 1.05, 5.40], non-adherence to treatment [AOR: 2.81; 95% CI: 1.30, 6.08] and smoking [AOR: 7.09; 95% CI: 1.84, 27.33] were found to be determinants of uncontrolled asthma.ConclusionsUncontrolled asthma is resulted from multiple sociodemographic, environmental, clinical, and behavioral factors. Therefore, interventions targeting to improve asthma control should consider those factors comprehensively.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

Geleta

Dadi

Sona

2020

Preprint

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“…Although several studies have been published on the prevalence and associated factors of non-adherence to inhaled medications among adult asthmatic patients in Ethiopia [18][19][20][21][22][23], the general prevalence remains unknown. Therefore, the primary purpose of this systematic review and meta-analysis is to determine the pooled national prevalence of non-adherence to inhaled medications among adult asthmatic patients in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Aberhe

Hailay

Zereabruk

et al. 2020

asthma res and pract

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Background Medication non-adherence is one of a common problem in asthma management and it is the main factor for uncontrolled asthma. It can result in poor asthma control, which leads to decreased quality of life, increase hospital admission, increased health care utilization, lost productivity, and mortality. To date, there have been no studies and protocols that estimated the pooled national prevalence of non-adherence to inhaled anti-asthmatic medications in Ethiopia. Therefore, the primary purpose of this systematic review and meta-analysis is to determine the pooled national prevalence of non-adherence to inhaled medications among asthmatic patients in Ethiopia. Methods Different database searching engines including PubMed, Scopus, Google Scholar, Africa journal online, World Health Organization afro library, and Cochrane review were systematically searched by using keywords such as “prevalence, non-adherence to inhaled medications, inhaled corticosteroids, and asthmatic patients” and their combinations. Six published observational studies that report the prevalence of non-adherence to inhaled medications were finally selected. The Preferred Reporting Items for Systematic Review and Meta-Analysis guideline was followed. Heterogeneity across the included studies was evaluated by the inconsistency index (I2). The random-effect model was fitted to estimate the pooled prevalence of non-adherence to inhale anti-asthmatic medications. All statistical analysis was done using R version 3.5.3 and R Studio version 1.2.5033 software for windows. Results The pooled national prevalence of non-adherence to inhaled medications among asthmatic patients was 29.95% (95% CI, 19.1, 40.8%). The result of this meta-analysis using the random-effects model revealed that there is high heterogeneity across the included studies. The result of subgroup analysis indicates that one out of three in the Oromia region and one out of five in the Amhara region asthmatic patients was non-adherent to their inhaled anti-asthmatic medications. Conclusion the prevalence of non-adherence to inhaled anti-asthmatic medications was high. Thus, our finding suggests that one out of four asthmatic patients were non-adherent to inhaled medications. The ministry of health, health policymakers, clinicians, and other health care providers should pay attention to strengthening the adherence levels to inhaled anti-asthmatic medications, and country-based interventions should be developed to reduce the burden of non-adherence to inhaled anti-asthmatic medications.

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“…Self-perceived poor asthma control was associated with any activity limitation due to asthma and inconsistent inhaled corticosteroid use [23]. Lack of health education on metered-dose inhaler technique [AOR = 4.96; 95% CI (1.08-22.89)] [29].…”

Section: Discussionmentioning

confidence: 99%

Uncontrolled Asthma in Ethiopia: A Systematic Review and Meta-Analysis

Tadesse

Negash

Kiros

et al. 2020

Advances in Respiratory Medicine

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Introduction: Despite significant improvement in the diagnosis and management of this disorder, asthma in the majority of Ethiopians remains poorly controlled. Although the prevalence of uncontrolled asthma is a public health problem in Ethiopia, its reported prevalence varies from study to study. Hence, this review aims to determine the true prevalence of uncontrolled asthma among asthmatic patients in Ethiopia. Material and methods: Different database searching engines were used including PubMed, Scopus, Google Scholar, Africa journal online, World Health Organization (WHO) afro library, and Cochrane review. They were systematically searched for published studies on uncontrolled asthma in Ethiopia from 2014 to 2019. Primary search terms were “asthma”, “uncontrolled asthma”, “uncontrolled wheezing”, and “Ethiopia”. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Guidelines was followed. Publication bias was examined by the funnel plot. The random-effect model was fitted to estimate the pooled prevalence of uncontrolled asthma among asthmatic patients. All statistical analysis was done using R version 3.5.3 and the RStudio version 1.2.5033 software for Windows. Results: The overall pooled prevalence of uncontrolled asthma was found to be 71.67% [95% CI (0.6772; 0.7562)]. Potential associated factors were: unscheduled visits, frequency of short-acting beta2-agonist (SABA) use, type of treatment and perceived rate of asthma control, low monthly income, age group, presence of comorbidity, moderate persistent asthma, severe persistent asthma and use of SABA alone as anti-asthmatic medication, use of biomass fuel for cooking, longer duration of asthma (> 30 years), incorrect inhalation technique, and asthma exacerbation in the last 12 months. Self-perceived poor asthma control was associated with any activity limitation due to asthma, inconsistent inhaled corticosteroid use, and lack of health education on metered-dose inhaler technique [AOR =4.96; 95% CI (1.08–22.89)]. Conclusions: Nearly two-thirds of patients were determined to have uncontrolled asthma. Thus, this evidence suggests that attention should be given to asthma patients and health care providers.

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Determinants of poorly controlled asthma among asthmatic patients in Jimma University Medical Center, Southwest Ethiopia: a case control study

Cited by 15 publications

References 11 publications

Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

Determinants of Uncontrolled Asthma Among Adult Asthmatic Patients on Follow-Up at Chest Clinic of Jimma Medical Center: Unmatched Case-Control Study

Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Uncontrolled Asthma in Ethiopia: A Systematic Review and Meta-Analysis

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