Determinants of Quality of Life in Pre-Frail Older Adults According to Phenotypic Criteria: the VERISAUDE Study

Maseda, Ana; Lorenzo-López, Laura; Lorenzo, Trinidad; Diego-Díez, Clara; Alonso-Búa, Begoña; López-López, Rocío; Millán-Calentí, José Carlos

doi:10.1007/s11482-017-9510-2

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…This was a cross-sectional secondary analysis of data and plasma samples collected in Spain and Portugal for parent projects examining links between frailty and inflammation ( 45 ), cognitive dysfunction ( 47 ), social factors ( 48 , 49 ), and environmental factors ( 50 ).…”

Section: Methodsmentioning

confidence: 99%

Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Mohyuddin,

Laffon,

Teixeira

et al. 2023

The Journals of Gerontology: Series A

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Background Persistent inflammation related to aging (“inflammaging”) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty. Methods We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome. Results In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant. Conclusions This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii–frailty association.

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Section: Methodsmentioning

confidence: 99%

Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Mohyuddin,

Laffon,

Teixeira

et al. 2023

The Journals of Gerontology: Series A

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Disability and functionality of older adults

García Miranda,

Valle Campo,

González Serra

et al. 2022

Interdisciplinary Rehabilitation / Rehabilitacion Interdiscipli

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Introduction: the population of all the countries of the Americas is in the process of aging, the Cuban population is no stranger to this social phenomenon that generates new damages to health. Objective: to characterize the disability and functionability of older adults belonging to the medical office 8 of the Policlínico Fermín Valdés Domínguez, Viñales municipality in 2018. Methods: an observational, analytical, and cross-sectional study was carried out, 256 older adults were identified as the universe, selecting a sample of 179 by simple random sampling. Theoretical and empirical methods were used to review the clinical histories and the Katz index and the Lawton scale were applied to determine functionability, descriptive and inferential statistics, the nonparametric Mann Whitney test and the Spearman test, all with a level of certainty of 95%; the data were included in tables and graphs for better understanding. Results: an average of 67 years of age and prevalence of female sex was observed; 54,7 % of the older adults did not present disability; diabetes mellitus was associated with special sensory system disability, 72,6 % were independent when applying Katz index and 69,3 % the Lawton scale, functionability decreases with age. Conclusions: most of the older adults did not present disabilities and maintained their functional capacity, which contributes to achieve a healthy longevity and better quality of life.

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Determinants of Quality of Life in Pre-Frail Older Adults According to Phenotypic Criteria: the VERISAUDE Study

Cited by 2 publications

References 64 publications

Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Disability and functionality of older adults

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