Determinants of quality of life and psychological status in adults with psoriasis

Abstract

We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively. One hundred individuals were recruited. Unadjusted analysis revealed that head involvement was associated with depression [odds ratio (OR) 8.509; 95% confidence interval (CI) 1.077-67.231] and anxiety (OR 6.46; 95% CI 1.401-29.858). Severe disease was associated with a poorer quality of life compared to mild disease (OR 3.750; 95% CI 1.330-10.577). Younger age was associated with an increased risk of depression [mean difference (MD) - 8.640; 95% CI - 16.390 to - 0.890], anxiety (MD - 11.553; 95% CI - 18.478 to- 4.628), stress (MD - 11.440; 95% CI - 19.252 to - 3.628) and severely impaired quality of life (MD - 12.338; 95% CI - 19.548 to - 5.127). Following adjustments for age and disease severity, anxiety, stress and depression remained associated with severely impaired quality of life.

Depression Symptoms Predict Worse Clinical Response to Etanercept Treatment in Psoriasis Patients

“…Finally, as the indexes for evaluating psoriasis severity, the higher scores of psoriasis-affected BSA and PASI represent more severe skin conditions of psoriasis, which is positively correlated with psychiatric conditions and may exacerbate depression and anxiety in psoriasis patients [1, 4]. Additionally, more severe disease is associated with poorer quality of life, which could also exacerbate mental disorder in psoriasis patients [19]. …”

Acceptance of Illness, Satisfaction with Life, Sense of Stigmatization, and Quality of Life among People with Psoriasis: A Cross-Sectional Study

“…Dermatological conditions, especially psoriasis, may cause isolation in interpersonal relationships [9]. Considering all of the above, this disease exerts an unfavorable effect on quality of life in people with psoriasis [10][11][12].…”

Epidemiology of Depression in Patients with Psoriasis: A Nationwide Population-based Cross-sectional Study

“…Patients with psoriatic skin disease usually present with erythematous plaques with silver scales on the skin, while patients with psoriatic arthritis present with joint pain and deformities (1)(2)(3). The disease has been shown to have detrimental effects on patients' functional abilities and quality of life (4)(5)(6)(7)(8)(9). Recent studies have also shown that psoriasis is not only a disease that affects the skin and joints, but that it may be associated with various systemic inflammatory and cardiometabolic diseases, including diabetes (10), hypertension (11), hyperlipidaemia (12), obesity (13), metabolic syndrome (14), myocardial infarction (15) and cerebrovascular disease (16).…”