Determinants of quality of life in Alzheimer's disease: perspective of patients, informal caregivers, and professional caregivers

Gómez-Gallego, María; Gómez-Amor, Jesús; Gómez-García, Juan

doi:10.1017/s1041610212001081

Cited by 62 publications

(85 citation statements)

References 48 publications

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“…This finding highlights the subjective nature of the concept of QoL. 43 Thus, other longitudinal studies including the pattern of PwD and caregiver individual differences would be interesting.…”

Section: Discussionmentioning

confidence: 89%

“…The impact of depression in this regard has been widely reported 7,41 and suggests the existence of differences between perceptions of psychological wellbeing that could be due to caregiver-related variables (personal beliefs or expectations). 43 Thus, it is acceptable to assume that there is an association between caregivers' perceptions of PwD QoL and PwD well-being in mild dementia. It seems that changes in caregiver scores are relatively dependent on the effect of change in other clinical parameters.…”

Section: Discussionmentioning

confidence: 99%

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Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

Dourado

Sousa

Santos

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: To determine changes over time in self and caregiver ratings of quality of life (QoL) in people with dementia (PwD) and to identify factors associated with changes in QoL ratings. Methods: In this longitudinal study, 69 people with mild Alzheimer's disease and their caregivers were assessed at baseline and after 1 year. We examined the association of QoL ratings with the following variables at the two time points: awareness of disease, cognitive status, mood, functionality, neuropsychiatric symptoms, and caregiver burden. Multivariate regression analyses were conducted to examine the contribution of co-factors. Results: At baseline, PwD self-ratings of QoL were associated with caregiver ratings of PwD QoL (p = 0.001). Caregiver ratings were associated with PwD mood (p = 0.001) and self-rated QoL (p = 0.001). After 1 year, caregiver ratings of PwD QoL changed significantly (p = 0.049, d = -0.27), whereas PwD selfratings did not (p = 0.89, d = 0.09). PwD awareness of disease changed significantly (p = 0.001) at 1 year, having declined in 25.4% and improved in 12.3% of participants. PwD QoL self-ratings were associated with caregiver ratings (p = 0.001). Caregiver ratings of PwD QoL after 1 year were associated with PwD mood (p = 0.029), self-reported QoL (p = 0.001), and awareness of disease (p = 0.033). Conclusions:The association between self and caregiver ratings of PwD QoL was maintained over 1 year. The primary factors accounting for the change in caregiver ratings were PwD mood and awareness of disease. QoL and cognitive impairment seem to be relatively independent in mild dementia.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

Dourado

Sousa

Santos

et al. 2016

Rev. Bras. Psiquiatr.

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“…Although depression is the neuropsychiatric symptom most widely reported to be associated with poorer QoL, this association with impaired QoL has also been found for the total NPI score [5,11,17], as well as for other specific neuropsychiatric symptoms, including apathy [39], anxiety [2,4], agitation [40], and psychotic symptoms assessed by the NPI (Delusions, Hallucinations) [5].…”

Section: Factors Associated With Qol In the Sample As A Wholementioning

confidence: 92%

“…Furthermore, the results obtained have been similar despite the variety of instruments used to assess depression: Cornell Scale for Depression in Dementia (CSDD) [2,4], Center for Epidemiologic Studies-Depression Scale (CES-D) [6], Hospital Anxiety and Depression Scale (HADS) [8], NPI-Depression [5,11,37], Geriatric Depression Scale (GDS) [18,36,38,39], Hamilton Depression Scale (HRSD) [35], and the Beck Depression Inventory (BDI) [34].…”

Section: Factors Associated With Qol In the Sample As A Wholementioning

confidence: 98%

“…The association between greater depression and lower scores on self-perceived QoL has been widely reported in longitudinal and cross-sectional studies of community samples [5,6,8,11,18,[34][35][36][37][38] and of patients attending day centers [39] or living in residential care [2,4,40]. Furthermore, the results obtained have been similar despite the variety of instruments used to assess depression: Cornell Scale for Depression in Dementia (CSDD) [2,4], Center for Epidemiologic Studies-Depression Scale (CES-D) [6], Hospital Anxiety and Depression Scale (HADS) [8], NPI-Depression [5,11,37], Geriatric Depression Scale (GDS) [18,36,38,39], Hamilton Depression Scale (HRSD) [35], and the Beck Depression Inventory (BDI) [34].…”

Section: Factors Associated With Qol In the Sample As A Wholementioning

confidence: 99%

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Self-Perceived Quality of Life Among Patients with Alzheimer’s Disease: Two Longitudinal Models of Analysis

Conde-Sala

Turró‐Garriga

Portellano-Ortiz

et al. 2016

JAD

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Abstract.The objective was to analyze the factors that influence self-perceived quality of life (QoL) in patients with Alzheimer's disease (AD), contrasting two different longitudinal models. A total of 127 patients were followed up over 24 months. The instruments applied were: Quality of Life in Alzheimer's Disease scale (QoL-AD), Geriatric Depression Scale-15, Anosognosia Questionnaire-Dementia, Disability Assessment in Dementia, Neuropsychiatric Inventory, and the Mini-Mental State Examination. Two models for grouping patients were tested: 1) Baseline score on the QoL-AD (QoLBaseline), and 2) Difference in QoL-AD score between baseline and follow-up (QoL-Change). Generalized estimating equations were used to analyze longitudinal data, and multinomial regression analyses were performed. Over the follow-up period the QoL-Baseline model showed greater variability between groups (Wald χ 2 = 172.3, p < 0.001) than did the QoLChange model (Wald χ 2 = 1.7, p = 0.427). In the QoL-Baseline model the predictive factors were greater depression (odds ratio [OR] = 1.20; 95% CI: 1.00-1.45) and lower functional ability (OR = 0.92; 95% CI: 0.85-0.99) for the Low QoL group (< 33 QoL-AD), and less depression (OR = 0.68; 95% CI: 0.52-0.88), more anosognosia (OR = 1.07; 95% CI: 1.01-1.13), and fewer neuropsychiatric symptoms (OR = 0.95; 95% CI: 0.91-0.99) for the High-QoL group (>37 QoL-AD). The model based on baseline scores (QoL-Baseline) was better than the QoL-Change model in terms of identifying trajectories and predictors of QoL in AD.

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Cognitive rehabilitation for people with mild to moderate dementia

Kudlicka

Martyr

Bahar‐Fuchs

et al. 2019

Cochrane Database of Systematic Reviews

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Determinants of quality of life in Alzheimer's disease: perspective of patients, informal caregivers, and professional caregivers

Cited by 62 publications

References 48 publications

Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

Self-Perceived Quality of Life Among Patients with Alzheimer’s Disease: Two Longitudinal Models of Analysis

Cognitive rehabilitation for people with mild to moderate dementia

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