Determinants of quality of life in first‐episode psychosis

Malla, Ashok; Norman, Ross; McLean, Terry; MacDonald, Cathy; McIntosh, Elizabeth; Dean-Lashley, F; Lynch, Jeannette; Scholten, Derek; Ahmed, R

doi:10.1046/j.0001-690x.2003.00221.x

Cited by 55 publications

(54 citation statements)

References 28 publications

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“…However other studies have found that patients with first-episode schizophrenia may also present with predominantly negative symptoms (Hovington et al, 2012; Malla et al, 2004). Studies have shown that patients with a higher PANSS total score or positive symptom score at baseline had greater reduction in global symptoms or positive symptoms after antipsychotic treatment (Levine and Rabinowitz, 2010; Walker et al, 2009).…”

Section: Discussionmentioning

confidence: 92%

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis

Shi

Cheung

et al. 2014

Psychiatry Research

118

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This study sought to determine the moderators in the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta-analysis of prospective studies on the therapeutic application of rTMS in schizophrenia assessing the effects of both low-frequency and high-frequency rTMS on negative symptoms. Results indicate that rTMS is effective in alleviating negative symptoms in schizophrenia. The effect size was moderate (0.63 and 0.53, respectively). The effect size of rTMS on negative symptoms in sham-controlled trials was 0.80 as measured by the SANS and 0.41 as measured by the PANSS. A longer duration of illness was associated with poorer efficacy of rTMS on negative symptoms. A 10 Hz setting, at least 3 consecutive weeks of treatment, treatment site at the left dorsolateral prefrontal cortex (DLPFC) and a 110% motor threshold (MT) were found to be the best rTMS parameters for the treatment of negative symptoms. The results of our meta-analysis suggest that rTMS is an effective treatment option for negative symptoms in schizophrenia. The moderators of rTMS on negative symptoms included duration of illness, stimulus frequency, duration of illness, position and intensity of treatment as well as the type of outcome measures used.

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Section: Discussionmentioning

confidence: 92%

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis

Shi

Cheung

et al. 2014

Psychiatry Research

118

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“…On the other hand, she emphasized that the relationship between negative symptoms and DUP is not well known. Prior studies have shown that negative symptoms at baseline are highly prevalent (Malla et al 2004b) and are associated with poor functional outcome (Malla et al 2004a), more resistance to treatment (Edwards et al 1999), more cognitive deficits (Heydebrand et al 2004), more social dysfunctioning (Addington and Addington 1993; Petersen et al 2008; Schmitz et al 2007) and poor quality of life (Schmitz et al 2007). She noted that positive symptoms are more responsive to treatment and have less impact on outcome.…”

Section: Outcomementioning

confidence: 99%

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Baharnoori

Bartholomeusz

Boucher³

et al. 2010

Schizophrenia Research

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The 2nd Schizophrenia International Research Society Conference, was held in Florence, Italy, April 10–15, 2010. Student travel awardees served as rapporteurs of each oral session and focused their summaries on the most significant findings that emerged from each session and the discussions that followed. The following report is a composite of these reviews. It is hoped that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research.

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“…The subjective QoL of schizophrenic patients is described as associated with depression, anxiety, negative, and-rarely-positive symptoms [10,[22][23][24][25]. Other studies have related to the role of social support [17,26], DUP [27] and stress-related factors [28]. Most previous studies on factors affecting QoL were cross-sectional, included patients with various durations of illness, and analysed only one of the two dimensions of QoL.…”

Section: Introductionmentioning

confidence: 96%

Determinants of objective and subjective quality of life in first-time-admission schizophrenic patients in Poland: a longitudinal study

et al. 2007

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Determinants of quality of life in first‐episode psychosis

Abstract: Domains of self-rated QOL in FEP patients are differentially associated with malleable and non-malleable aspects of patient and illness characteristics.

Cited by 55 publications

References 28 publications

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Determinants of objective and subjective quality of life in first-time-admission schizophrenic patients in Poland: a longitudinal study

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