Determinants of serum brain-derived neurotrophic factor

Bus, Boudewijn A.A.; Molendijk, Marc L.; Penninx, Brenda; Buitelaar, Jan K.; Kenis, Günter; Prickaerts, Jos; Elzinga, Bernet M.; Voshaar, Richard C. Oude

doi:10.1016/j.psyneuen.2010.07.013

Cited by 253 publications

(242 citation statements)

References 74 publications

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“…In our sample, the mean sBDNF level was 18.27 ng/ml, which is in line with earlier reports of elderly populations (Erickson et al, 2010;Bus et al, 2012;Rapinesi et al, 2015) but lower compared with levels ranging from 9.5 to 29.0 μg/ml in non-elderly depressed patients (Sen et al, 2008). Differences in the sBDNF level could also be explained by sample characteristics and protocols used (eg, urbanicity, sex, smoking status, time of blood withdrawal, and so on; Bus et al, 2011). Similar to the observation from a large longitudinal study showing that initiation or discontinuation of antidepressants is not associated with sBDNF change (p = 0.72; Bus et al, 2015), we did not find any differences between the subjects who continued antidepressant therapy with the non-medicated sample.…”

Section: Relationship Between Clinical Response and Sbdnfsupporting

confidence: 81%

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Bouckaert

Dols

Emsell

et al. 2016

Neuropsychopharmacol

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Recent structural imaging studies have described hippocampal volume changes following electroconvulsive therapy (ECT). It has been proposed that serum brain-derived neurotrophic factor (sBDNF)-mediated neuroplasticity contributes critically to brain changes following antidepressant treatment. To date no studies have investigated the relationship between changes in hippocampal volume, mood, and sBDNF following ECT. Here, we combine these measurements in a longitudinal study of severe late-life unipolar depression (LLD). We treated 88 elderly patients with severe LLD twice weekly until remission (Montgomery-Åsberg Depression Rating Scale (MADRS) o10). sBDNF and MADRS were obtained before ECT (T0), after the sixth ECT (T1), 1 week after the last ECT (T2), 4 weeks after the last ECT (T3), and 6 months after the last ECT (T4). Hippocampal volumes were quantified by manual segmentation of 3T structural magnetic resonance images in 66 patients at T0 and T2 and in 23 patients at T0, T2, and T4. Linear mixed models (LMM) were used to examine the evolution of MADRS, sBDNF, and hippocampal volume over time. Following ECT, there was a significant decrease in MADRS scores and a significant increase in hippocampal volume. Hippocampal volume decreased back to baseline values at T4. Compared with T0, sBDNF levels remained unchanged at T1, T2, and T3. There was no coevolution between changes in MADRS scores, hippocampal volume, and sBDNF. Hippocampal volume increase following ECT is an independent neurobiological effect unrelated to sBDNF and depressive symptomatology, suggesting a complex mechanism of action of ECT in LLD.

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Section: Relationship Between Clinical Response and Sbdnfsupporting

confidence: 81%

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Bouckaert

Dols

Emsell

et al. 2016

Neuropsychopharmacol

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“…Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011). Since lower serum or plasma BDNF levels are found in obesity (Araya et al, 2008;El-Gharbawy et al, 2006;Gray et al, 2006;Krabbe et al, 2007;Lommatzsch et al, 2005), compared to normal weight subjects, although opposite results also exist (Bus et al, 2011;Iughetti et al, 2011), our data suggest that carriers of one or two Met alleles in our study had decreased amount of the mature BDNF, possibly lower plasma BDNF levels, and therefore they had higher values of BMI and were more frequently obese. This speculation might be confirmed by the fact that weight gain, induced by antipsychotic drugs, is associated with BDNF serum levels in female schizophrenic patients, while carriers of the Met/Met genotype have lower BDNF levels than carriers of the Val allele (Zhang et al, 2008).…”

Section: Discussionmentioning

confidence: 52%

“…Its location in the hypothalamic regions such as the paraventricular, arcuate and ventromedial nuclei points to its role in feeding behavior, food intake regulation, energy expenditure, energy homeostasis, glucose homeostasis and weight control (Lebrun et al, 2006;Noble et al, 2011). There are reports of a positive (Bus et al, 2011;Iughetti et al, 2011), as well as inverse relationship (Araya et al, 2008;Gray et al, 2006;Han et al, 2008) and lack of association (Saito et al, 2009), between serum and/or plasma BDNF levels and obesity or BMI. The secretion of the precursor and the mature BDNF protein is affected by the single nucleotide polymorphism (SNP), dbSNP reference number rs6265, in the coding region of exon V of the BDNF gene, located on chromosome 11p13-11p14.…”

Section: Introductionmentioning

confidence: 99%

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Škledar¹,

Nikolac

Dodig-Ćurković

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…This single nucleotide polymorphism affects the intracellular trafficking of pro-BDNF and the secretion of the mature peptide with the Met allele, which is related to a decrease in the activity-dependent secretion of BDNF compared to the Val allele (Egan et al, 2003). Although some studies determined the association between cigarette smoking and BDNF concentration, as well as the Val66Met BDNF gene polymorphism, the results from these studies are inconsistent (Bhang et al, 2010;Zhang et al, 2010;Bus et al, 2011;Breetvelt et al, 2012). However, no studies have investigated the combination of the Val66Met BDNF genotype and BDNF levels in smokers and non-smokers among Thai subjects.…”

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males

Suriyaprom¹,

Tungtrongchitr²,

Thawnashom³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met BDNF gene polymorphism with BDNF serum levels and cigarette smoking. The study sample comprised 311 Thai volunteers (200 smokers; 111 non-smokers). The levels of serum BDNF and biochemical-hematological parameters were determined. The Val66Met BDNF polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism technique. The smoker group had significantly higher serum BDNF levels than the non-smoker group (8.3 vs 6.5 ng/mL, P < 0.05). BDNF concentrations correlated positively with hemoglobin, hematocrit, red blood cell count, white blood cell count, platelet count, number of cigarettes smoked, and thiocyanate level (P < 0.05). No association was found between the BDNF Val66Met genotype and the serum BDNF level. The BDNF Val66Met polymorphism was not significantly associated with the smoking status of the Thai males in this study. Cigarette smoking may be one factor that determines the serum BDNF level, but the BDNF Val66Met polymorphism probably does not influence susceptibility to smoking among Thai males.

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Determinants of serum brain-derived neurotrophic factor

Cited by 253 publications

References 74 publications

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males

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