Determinants of sex hormone—binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status

Pasquali, Renato; Vicennati, Valentina; Bertazzo, Doriana; Casimirri, Francesco; Pascal, G.; Tortelli, Ornella; Morselli-Labate, Antonio Maria

doi:10.1016/s0026-0495(97)90159-1

Cited by 108 publications

(87 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oestrogen is involved in the control of the secretion of both growth hormone (Malaab et al, 1992;Veldhuis, 1996;Veldhuis et al, 2001) and prolactin (Yen et al, 1974;Adashi et al, 1980;Gudelsky et al, 1981), and regulates the synthesis and blood levels of SHBG (Loukovaara et al, 1995;Pasquali et al, 1997). Although blood levels of oestradiol were not positively associated with mammographic density in the present study, other forms of oestrogen not measured here, including oestrogen metabolites, might be responsible for the observed findings.…”

Section: Discussioncontrasting

confidence: 52%

The association of breast mitogens with mammographic densities

et al. 2002

View full text Add to dashboard Cite

Radiologically dense breast tissue (mammographic density) is strongly associated with risk of breast cancer, but the biological basis for this association is unknown. In this study we have examined the association of circulating levels of hormones and growth factors with mammographic density. A total of 382 subjects, 193 premenopausal and 189 postmenopausal, without previous breast cancer or current hormone use, were selected in each of five categories of breast density from mammography units. Risk factor information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured. Mammograms were digitised and measured using a computer-assisted method. After adjustment for other risk factors, we found in premenopausal women that serum insulin-like growth factor-I levels, and in postmenopausal women, serum levels of prolactin, were both significantly and positively associated with per cent density. Total oestradiol and progesterone levels were unrelated to per cent density in both groups. In postmenopausal women, free oestradiol (negatively), and sex hormone binding globulin (positively), were significantly related to per cent density. These data show an association between blood levels of breast mitogens and mammographic density, and suggest a biological basis for the associated risk of breast cancer.

show abstract

Section: Discussioncontrasting

confidence: 52%

The association of breast mitogens with mammographic densities

et al. 2002

View full text Add to dashboard Cite

show abstract

“…6,35 Under the effect of estrogenic depletion after menopause, the postmenopausal women had lower sex hormone binding globulin, relatively higher androgenicity and higher activity of lipoprotein lipase in the abdominal subcutaneous adipose tissue than the premenopausal women. 8,13,36,37 These physiological changes may result in a more male, central adipose tissue distribution after menopause. 11 Meanwhile, the fact that hormone replacement therapy can prevent central distribution of body fat indicates the important role of the sex hormone.…”

Section: Discussionmentioning

confidence: 99%

“…The ®rst argument is whether the menopause-related changes in body fat distribution are independent of age and general obesity. Most of the studies using indirect anthropometric methods (waist-to-hip ratio, waist circumference) have failed to con®rm the menopause-related effect on central obesity that was independent of age and body mass index, 12,13 whereas others found supportive results. 14 The more precise methods (dual-energy X-ray absorptiometry (DEXA) or computed tomography) provided contrasting reports on the level of central obesity which would be increased during menopause, 15 ± 18 whereas other investigators have suggested that these changes are more dependent on age.…”

Section: Introductionmentioning

confidence: 99%

Relationships of age, menopause and central obesity on cardiovascular disease risk factors in Chinese women

Chang

Yao

et al. 2000

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE: To evaluate the inter-relationships of age-and menopause-related changes of general obesity and body fat distribution and their independent effects on cardiovascular risk factors. DESIGN: Cross-sectional study. SUBJECTS: One-hundred and thirty-six premenopausal and 193 postmenopausal Chinese women with body mass index (BMI)`30 kgam 2 . MEASUREMENTS: Anthropometric surrogates of general obesity (BMI, total body fat percentage) and central obesity (waist-to-hip ratio, centrality index) were measured. Blood pressure, 75 g oral glucose tolerance test, glycosylated hemoglobin A 1c and lipid pro®les were also measured. RESULTS: Signi®cant correlation coef®cients between age, general obesity, central obesity and cardiovascular disease risk factors were noted. Through the menopausal transition, the BMI and total body fat percentage were increased signi®cantly. After adjustments for age and BMI, the postmenopausal women showed higher android fat percentage, centrality index, glycosylated hemoglobin A 1c , serum concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol and atherogenic indices than the premenopausal women. In multiple stepwise regression models, age exerted independent effects on oral glucose tolerance test 2 h plasma glucose level, systolic and diastolic blood pressure, total cholesterol level, and LDL cholesterol. Menopause was an independent variable in relation to the changes of glycosylated hemoglobin A 1c , total and LDL cholesterol levels, triglyceride levels and atherogenic indices. The centrality index was the major independent variable of all the cardiovascular disease risk factors, except total and LDL cholesterol level. However, the variation of total body fat percentage had no independent effect on any cardiovascular disease risk factors. CONCLUSION: Through the aging and menopausal effects, women will increase total body fat content, favoring the central body fat distribution. Age, menopause and central obesity were all independent and signi®cant factors to the cardiovascular disease risk factors in Chinese women.

show abstract

“…Many different factors contribute, including marked hormonal changes,2 changes in metabolic profile associated with increased risk of the metabolic syndrome,3 and relative increase in intra‐abdominal fat with age 4. Accumulation of intra‐abdominal fat is associated with increased waist circumference and liver fat,5 overproduction of very low‐density lipoprotein (VLDL), and decreased catabolism of apolipoprotein (apo)B‐containing particles in men 6.…”

Section: Introductionmentioning

confidence: 99%

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Hodson

Banerjee

Rial

et al. 2015

JAHA

View full text Add to dashboard Cite

BackgroundAndroid fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low‐density lipoprotein (VLDL) particles in men. Since abdominal obesity is becoming increasingly prevalent in women, we aimed to investigate the relationship between android fat and hepatic lipid metabolism in pre‐ and postmenopausal women.Methods and ResultsWe used a combination of stable isotope tracer techniques to investigate intrahepatic fatty acid synthesis and partitioning in 29 lean and 29 abdominally obese women (android fat/total fat 0.065 [0.02 to 0.08] and 0.095 [0.08 to 0.11], respectively). Thirty women were premenopausal aged 35 to 45 and they were matched for abdominal obesity with 28 postmenopausal women aged 55 to 65. As anticipated, abdominal obese women were more insulin resistant with enhanced hepatic secretion of large (404±30 versus 268±26 mg/kg lean mass, P<0.001) but not small VLDL (160±11 versus 142±13). However, postmenopausal status had a pronounced effect on the characteristics of small VLDL particles, which were considerably triglyceride‐enriched (production ratio of VLDL 2‐ triglyceride:apolipoprotein B 30±5.3 versus 19±1.6, P<0.05). In contrast to postmenopausal women, there was a tight control of hepatic fatty acid metabolism and triglyceride production in premenopausal women, whereby oxidation (r s=−0.49, P=0.006), de novo lipogenesis (r s=0.55, P=0.003), and desaturation (r s=0.48, P=0.012) were closely correlated with abdominal obesity‐driven large VLDL‐triglyceride secretion rate.ConclusionsIn women, abdominal obesity is a major driver of hepatic large VLDL particle secretion, whereas postmenopausal status was characterized by increased small VLDL particle size. These data provide a mechanistic basis for the hyperlipidemia observed in postmenopausal obesity.

show abstract

Determinants of sex hormone—binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status

Cited by 108 publications

References 20 publications

The association of breast mitogens with mammographic densities

The association of breast mitogens with mammographic densities

Relationships of age, menopause and central obesity on cardiovascular disease risk factors in Chinese women

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Contact Info

Product

Resources

About