Determinants of splenic preservation among patients with sickle cell disease in North‐Eastern Nigeria

Ladu, Adama Isah; Jeffery, Caroline; Farate, Abubakar; Farouk, Abubakar Garba; Abba, Aisha Mohammed; Adekile, Adekunle; Bates, Imelda

doi:10.1111/tmi.13910

Tropical Med Int Health

2023

DOI: 10.1111/tmi.13910

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Determinants of splenic preservation among patients with sickle cell disease in North‐Eastern Nigeria

Adama Isah Ladu

Caroline Jeffery

Abubakar Farate

et al.

Abstract: Objective: In patients with sickle cell disease (SCD), the spleen commonly enlarges during early childhood, but undergoes reduction in size and fibrosis from repeated episodes of vaso-occlusion and infarction. The rate of progression of this process varies markedly among these patients. The aim of current study was to explore clinical and laboratory factors associated with the preservation of the spleen among these patients. Methods: Two hundred four patients with SCD (103 females; age 1-45 years) underwent ab… Show more

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2024

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Cited by 2 publications

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Malaria Infection in Patients with Sickle Cell Disease in Nigeria: Association with Markers of Hyposplenism

Ladu,

Kadaura,

Dauda

et al. 2024

Hemoglobin

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Malaria Infection in Patients with Sickle Cell Disease in Nigeria: Association with Markers of Hyposplenism

Ladu,

Kadaura,

Dauda

et al. 2024

Hemoglobin

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Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review

Musuka,

Iradukunda,

Mano

et al. 2024

TropicalMed

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Sickle cell disease (SCD) is a prevalent inherited blood disorder, particularly affecting populations in Africa. This review examined the disease’s burden, its diverse clinical presentations, and the challenges associated with its management in African settings. Africa bears a significant burden of SCD, with prevalence varying across countries and age groups. Newborn screening programs have highlighted the high prevalence of SCD at birth, emphasizing the need for early diagnosis and intervention. The clinical manifestations of SCD in Africa are multifaceted, encompassing acute complications like vaso-occlusive crises, acute chest syndrome, and stroke, as well as chronic complications such as organ damage and leg ulcers. Biological factors, including fetal hemoglobin levels, and demographic factors, like age and sex, influence disease severity and outcomes. The management of SCD in Africa faces numerous challenges. Limited access to resources, including diagnostic tools, medications, and trained healthcare professionals, hinders optimal care. The high cost of advanced therapies further restricts patient access. Cultural stigma and a lack of awareness create additional barriers to effective management. To address these challenges, early diagnosis through newborn screening programs and point-of-care testing is crucial. Comprehensive care models, including hydroxyurea therapy, pain management, and patient education, are essential for improving outcomes. Collaboration with international networks and leveraging local resources can enhance the sustainability of SCD programs. In conclusion, SCD significantly impacts African populations. Overcoming the challenges associated with its management requires addressing resource limitations, affordability issues, and cultural barriers. Early diagnosis, comprehensive care models, and ongoing research focused on affordability and accessibility are crucial for improving the lives of individuals living with SCD in Africa.

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Determinants of splenic preservation among patients with sickle cell disease in North‐Eastern Nigeria

Cited by 2 publications

References 51 publications

Malaria Infection in Patients with Sickle Cell Disease in Nigeria: Association with Markers of Hyposplenism

Malaria Infection in Patients with Sickle Cell Disease in Nigeria: Association with Markers of Hyposplenism

Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review

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