Determinants of the Change in Arterial Stiffness in Peritoneal Dialysis Patients

Nakahigashi, Mitsutaka; Tsukaguchi, Hiroyasu; Morimoto, Satoshi; Nakano, Chikara; Ueda, Hiroko; Someya, Kazunori; Kusabe, Makiko; Kikuchi, Satoru; Imada, Takanobu; Shiojima, Ichiro

doi:10.1536/ihj.16-624

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Forth, uric acid may disturb the natural turnover of non-cross-linked soluble elastin, an important contributor of vascular stiffness [30]. In addition, SUA may interact with conventional and dialysis-specific risk factors in end-stage renal disease patients to promote arterial stiffness progression [31,32].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients

Liu

et al. 2018

Kidney Blood Press Res

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Background/Aims: Serum uric acid (SUA) has been proposed as a mediator associated with increased cardiovascular risk and arterial stiffness. However, evidence on the association between SUA and arterial stiffness in peritoneal dialysis (PD) patients is lacking. The aim of this study was to examine the relationship between SUA and arterial stiffness in PD patients. Methods: The patients who performed vascular profiler test from January 1, 2014 to October 31, 2016, and with SUA values were enrolled. Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). The relationship between SUA and baPWV was tested by multiple linear regression models. Results: Of 645 PD patients, mean SUA was 6.80 (±1.29) mg/dL, mean baPWV was 1713 (±505) cm/s. In fully adjusted linear regression models, higher SUA was significantly associated with higher baPWV in young [standardized coefficients (β), 0.085; 95% confidence interval (95% CI), 0.013 to 0.130; P=0.02] but not in elderly (β, -0.194; 95% CI, -0.774 to 0.093; P=0.1) PD patients. In gender-stratified models of young patients, there was a significant association between SUA and baPWV in male (β, 0.115; 95% CI, 0.015 to 0.182; P=0.02) but not in female. Male in the highest gender-specific SUA quartile had a higher baPWV than those in the lowest quartile (β, 0.132; 95% CI, 0.011 to 0.209; P=0.03). This gender difference was reversed when selecting male patients with lower SUA levels (quartile 1 and 2) and female patients with higher SUA levels (quartile 3 and 4). Conclusion: SUA was positively associated with baPWV in young PD patients, and this association was significant in males but not in females, which is possibly explained by the higher SUA level in males than in females.

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Section: Discussionmentioning

confidence: 99%

Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients

Liu

et al. 2018

Kidney Blood Press Res

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“…Our results showed no differences in baPWV between the r-CoA and control groups. Although baPWV does not require professional skills compared with carotidfemoral PWV, 16,27) baPWV reflects the mechanics at both the proximal and distal sides of coarctation. A number of studies investigated the PWV of the proximal side to coarctation, such as the brachial to radial artery, and demonstrated the acceleration of the regional velocity.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction of Conduit Arteries in Patients with Repaired Coarctation of the Aorta

et al. 2018

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Adult patients with repaired coarctation of the aorta (r-CoA) show high prevalence of late hypertension, but the exact mechanisms of this phenomenon are unknown. Endothelial dysfunction has been implicated in this paradoxical hypertension. We evaluated the endothelial function of both conduit and resistance arteries by using flow-mediated dilation (FMD) and digital peripheral artery tonometry (PAT). Seventeen patients with r-CoA and one patient with repaired interrupted aortic arch (r-CoA group) aged 22.0 ± 6.9 years (5 females) underwent FMD of the right brachial artery, PAT of the right finger, blood marker tests, ambulatory blood pressure monitoring, echocardiography, carotid ultrasonography, and brachio-ankle pulse wave velocity measurement. The median age at aortic arch reconstruction was 2.0 months (interquartile range: 15 days to 7.0 years). Results were compared with 17 age-matched healthy subjects (control group). Eight (44%) patients of the r-CoA group were hypertensive (5 received antihypertensive drugs). Patients in the r-CoA group showed significantly lower FMD (3.8 ± 1.5 versus 6.6 ± 2.5%, P < 0.001), larger intimamedia thickness (0.63 ± 0.17 versus 0.47 ± 0.09 mm, P = 0.001), and higher left ventricular mass index (91.4 ± 24.6 versus 73.4 ± 17.3 g/m 2 , P = 0.017) than those in the control group. There were no significant differences in PAT (refractory hyperemia index, 1.86 ± 0.43 versus 1.99 ± 0.59, P = 0.48) and brachio-ankle pulse wave velocity between the two groups. Vascular dysfunction in r-CoA patients, particularly endothelial dysfunction, tends to occur more significantly in conduit arteries than in resistance arteries.

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The effect of sodium exchange and dialytic biochemical parameters on blood pressure, arterial stiffness, and endothelial functions in patients with peritoneal dialysis

et al. 2020

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Determinants of the Change in Arterial Stiffness in Peritoneal Dialysis Patients

Cited by 4 publications

References 33 publications

Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients

Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients

Endothelial Dysfunction of Conduit Arteries in Patients with Repaired Coarctation of the Aorta

The effect of sodium exchange and dialytic biochemical parameters on blood pressure, arterial stiffness, and endothelial functions in patients with peritoneal dialysis

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