Determinants of the Morning-Evening Home Blood Pressure Difference in Treated Hypertensives: The HIBA-Home Study

Aparicio, Lucas S.; Barochiner, Jessica; Cuffaro, Paula E.; Alfie, José; Rada, Marcelo A.; Morales, Margarita S.; Galarza, Carlos; Marín, Marcos J.; Waisman, Gabriel

doi:10.1155/2014/569259

Cited by 9 publications

(9 citation statements)

References 45 publications

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“…The baseline characteristics of each cohort appear in Tables S3 and S4 for untreated and treated participants, respectively. The median number (5th to 95th percentile interval) of home blood pressure measurements amounted to 48 (8-56) in Ohasama, 10 (2-34) in Tsurugaya, 12 in Didima, and 24 (22)(23)(24)(25)(26)(27)(28) in Buenos Aires. Among treated participants belonging to the Ohasama, Tsurugaya, and Buenos Aires cohorts, 80 (50.6%) were on monotherapy and 78 (49.4%) were on combination therapy taking a median of 1.0 drug per day.…”

Section: Resultsmentioning

confidence: 99%

“…The analysis included 144 (untreated/treated, 106/38) residents of Ohasama, Japan 21 ; 137 (75/62) inhabitants of the Tsurugaya district in Sendai, Japan 22 ; 36 (21/15) inhabitants of Didima, Greece 23 ; and 58 treated outpatients of a general hospital in Buenos Aires, Argentina. 24 All studies received ethical approval. Participants provided written informed consent.…”

Section: Study Populationmentioning

confidence: 99%

“…Office blood pressure was the average of 2 readings obtained with a standard mercury sphygmomanometer, 23 or with an automated auscultatory 21 or oscillometric device, 22,24 using the appropriate cuff size. All home blood pressure measurements were performed in the sitting position with a validated oscillometric device, [21][22][23][24] using the appropriate cuff size.…”

Section: Collection Of the Baseline Datamentioning

confidence: 99%

“…All home blood pressure measurements were performed in the sitting position with a validated oscillometric device, [21][22][23][24] using the appropriate cuff size. The average of all available home measurements was used in the analysis.…”

Section: Collection Of the Baseline Datamentioning

confidence: 99%

“…24 The Expanded Methods in the online only Data Supplement provide information on the collection of anthropometric and biochemical data.…”

Section: Collection Of the Baseline Datamentioning

confidence: 99%

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Defining Thresholds for Home Blood Pressure Monitoring in Octogenarians

et al. 2015

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To generate outcome-driven thresholds for home blood pressure (BP) in the elderly, we analyzed 375 octogenarians (60.3% women; 83.0 years [mean]) enrolled in the International Database on home BP in relation to cardiovascular outcome. Over 5.5 years (median), 155 participants died, 76 from cardiovascular causes, whereas 104, 55, 36, and 51 experienced a cardiovascular, cardiac, coronary, or cerebrovascular event, respectively. In 202 untreated participants, home diastolic in the lowest fifth of the distribution (≤65.1 mm Hg) compared with the multivariable-adjusted average risk was associated with increased risk of cardiovascular mortality and morbidity (hazard ratios [HRs], ≥1.96; P ≤0.022), whereas the HR for cardiovascular mortality in the top fifth (≥82.0 mm Hg) was 0.37 ( P =0.034). Among 173 participants treated for hypertension, the HR for total mortality in the lowest fifth of systolic home BP (<126.9 mm Hg) was 2.09 ( P =0.020). In further analyses of home BP as continuous variable (per 1-SD increment), higher diastolic BP predicted lower cardiovascular mortality and morbidity and cardiac and coronary risk (HR≤0.65; P ≤0.039) in untreated participants. In those treated, cardiovascular morbidity was curvilinearly associated with systolic home BP with nadir at 148.6 mm Hg and with a 1.45 HR ( P =0.046) for a 1-SD decrease below this threshold. In conclusion, in untreated octogenarians, systolic home BP ≥152.4 and diastolic BP ≤65.1 mm Hg entails increased cardiovascular risk, whereas diastolic home BP ≥82 mm Hg minimizes risk. In those treated, systolic home BP <126.9 mm Hg was associated with increased total mortality with lowest risk at 148.6 mm Hg.

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Section: Resultsmentioning

confidence: 99%