Police interactions with persons in crisis (PICs) have been steadily increasing. To reduce the need for police involvement with PICs, some communities have implemented civilian-led teams.A systematic review of 51 documents was conducted to determine how these teams operate and whether they are effective. The findings indicate that civilian-led teams receive many calls for service, response rates are generally high, the teams respond quickly to most calls, but the police are still involved in crisis calls to varying degrees. The most common call outcomes include hospitalizations, informal conversations/check-ups, diversions from the hospital, and community support referrals. Interactions appear to be low-risk and outcomes appear better for civilian-led teams compared to alternative programs. Service users generally present positive views of civilian-led teams; however, service providers and the police provide mixed perspectives. While additional high-quality comparative studies are needed, we recommend communities consider implementing civilian-led teams to improve service to PICs.