Determinants of the Very Low-Birth-Weight Infant's Intestinal Microbiome

Desorcy-Scherer, Katelyn; Bendixen, Marion M; Parker, Leslie A.

doi:10.1097/jpn.0000000000000506

Cited by 7 publications

(11 citation statements)

References 69 publications

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“…Meanwhile, the limitation is that because this is a cross-sectional study, the authors cannot confirm a temporal relationship between exposure and outcome variables. Another limitation is that it did not investigate some of the known risk factors from previous studies for LBW, including dietary and nutritional factors 42,43 , genetic factors, and [44][45][46] , as well as pollution and environmental factors 47,48 . This limitation is more due to limited secondary data from the 2017 IDHS.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Socioeconomic Disparities of Low Birth Weight in Rural Indonesia

Laksono

Wulandari

Matahari

2020

Preprint

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Background: Poverty is estimated to increase a mother's chances of giving birth to a low birth weight baby (LBW). Objective: This study aimed to analyze the socioeconomic disparities of LBW in rural Indonesia.Methods: Mother aged 15-49 years old who had given birth in the last 5 years in rural Indonesia was used as the unit of analysis. With stratification and multistage random sampling found 19,283 mothers were sampled. The variables analyzed included LBW, socioeconomic, age, marital, education, employment, and antenatal care (ANC). The binary logistic regression test was used at the final stage to determine the existence of disparities.Results: The results show that the mother with the poorer wealth status was 0.686 times more likely than the poorest mother to give birth to an LBW baby. Mothers with middle wealth status were 0.688 times more likely than the poorest mothers to give birth to LBW babies. Mothers with richer wealth status were 0.621 times more likely than the poorest mothers to give birth to LBW babies. Finally, the richest mothers were 0.452 times more likely than the poorest mothers to give birth to LBW babies. The results of this analysis inform that the better the socioeconomic of mothers, the lower the likelihood of giving birth to LBW babies. Apart from socioeconomics, the analysis also found two other predictors of LBW in rural Indonesia, namely education level and ANC visits.Conclusion: It was concluded that there were socioeconomic disparities of LBW in rural Indonesia.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Socioeconomic Disparities of Low Birth Weight in Rural Indonesia

Laksono

Wulandari

Matahari

2020

Preprint

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“…Feeding of predominantly MOM increased intestinal microbial diversity compared with DHM, and even small quantities of MOM were associated with a more favorable microbial community in all but one of the studies. 30,31,36,38 Although Parra-Llorca et al 32 were unable to detect differences in microbial diversity and richness, they concluded that feeding type significantly influenced the preterm intestinal microbial composition, with infants fed MOM showing a significant greater presence of nonpathogenic bacteria. In contrast, a higher abundance of potentially pathogenic bacterial was identified in infants fed DHM.…”

Section: Discussionmentioning

confidence: 99%

Differences in Neonatal Outcomes Among Premature Infants Exposed to Mother's Own Milk Versus Donor Human Milk

Cartagena

Penny²,

McGrath³

et al. 2022

Advances in Neonatal Care

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Background: Growing evidence supports the superior benefits of exposure to mother's own milk (MOM) in reducing prematurity-related comorbidities. Neonatal exposure to donor human Milk (DHM) is a suitable alternative when MOM is insufficient or unavailable. However, the same protective composition and bioactivity in MOM are not present in DHM. Additional evidence is needed to justify and inform evidence-based practices increasing MOM provision while optimizing adequate use of DHM for premature infants. Purpose: A systematic review of the literature was conducted to determine differences in neonatal outcomes among premature infants exposed to predominately MOM versus DHM. Methods/Search Strategy: Databases including PubMed, CINAHL and Cochrane were searched (2020-2021) using the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. Evidence was classified using the John Hopkins evidence-based practice levels and quality of evidence. Results: Eleven studies met inclusion criteria. Studied neonatal outcomes included (a) growth parameters (n = 8), (b) neonatal morbidities (n = 6), and (c) gut microbiome (n = 4). Overall, evidence suggests DHM exposure is beneficial but not equivalent to MOM feeding. Compared with DHM, greater doses of MOM are ideal to enhance protection primarily related to infant growth, as well as gut microbiome diversity and richness. Implications for Practice: Standardized and evidence-based practices are needed to clearly delineate optimal use of DHM without undermining maternal and neonatal staff efforts to support and promote provision of MOM. Implications for Research: Additional evidence from high-quality studies should further examine differences in neonatal outcomes among infants exposed to predominately MOM or DHM in settings using standardized and evidence-based feeding practices.

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“…Spread to the amnion could be either hematogenous via transient bacteremia. TNF-a and interleukin-6 (IL-6) have been shown to cross human fetal membranes in an in vitro culture study[ 26 27 ] Although it is difficult to extrapolate these results to the in vivo situation, it is plausible that infections remote from the genitourinary tract such as in periodontal disease could influence the fetal-placental unit.…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and preterm low birth weight in human immunodeficiency virus seropositive pregnant women in India: A cohort study

Kiran¹,

Karnam²,

Ramya³

et al. 2022

Journal of Family Medicine and Primary Care

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A BSTRACT Background & Objectives: Because of the inflammatory response to human immunodeficiency virus (HIV) infection and periodontitis risk of developing adverse pregnancy outcomes are high. There is a limited number of studies available in the literature regarding the association between periodontitis and adverse pregnancy outcomes, especially in HIV infection. So the main objective of the present study was to assess the risk of preterm low birth weight (PTLBW) associated with periodontitis among HIV seropositive pregnant women. Methods: The study sample consists of 216 HIV seropositive pregnant women with complete dental and medical history and the appointment for the follow-up visit was made after the delivery to assess the baby’s health.Gingivitis and periodontitis were assessed based on the bleeding on probing and clinical attachment levels at the first visit. Results: In our study, the majority of 96 (44.44%) of the gingivitis cases belong to “moderate gingivitis” and the majority of 62 (28.70%) of the periodontitis cases were found to be in the mild periodontitis category. The relative risk for women with gingivitis or periodontitis having a preterm birth, low birth weight, and PTLBW was not statistically significant. The trend of risk ratios was found to be increased over the severity of periodontitis. Conclusion: This study shows an association between adverse neonatal outcomes with moderate and severe periodontitis. But these results were not statistically significant. This study implicates the importance of oral health care in HIV-positive pregnant women.

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Determinants of the Very Low-Birth-Weight Infant's Intestinal Microbiome

Cited by 7 publications

References 69 publications

Socioeconomic Disparities of Low Birth Weight in Rural Indonesia

Socioeconomic Disparities of Low Birth Weight in Rural Indonesia

Differences in Neonatal Outcomes Among Premature Infants Exposed to Mother's Own Milk Versus Donor Human Milk

Association between periodontitis and preterm low birth weight in human immunodeficiency virus seropositive pregnant women in India: A cohort study

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