Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries

Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies

“…In line with results from a recent European study [37], more male survivors cryopreserved, likely because sperm collection is less invasive and costly, but possibly also due to differences in counseling [38]. Our data showed that even in cases lacking pretreatment oocytes/sperm cryopreservation, successful ART pregnancies occurred in childhood cancer survivors.…”

Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

“…127 To overcome barriers in communicating infertility risk and fertility preservation, interventions have been developed to promote and facilitate discussions between health-care providers and patients and families. 26,[35][36][37][38][39][40] Studies have shown that including fertility preservation discussions in the clinical care pathway (with all relevant documentation easily accessible, such as electronic flowcharts, instruction booklets, checklists, referral forms, and handouts for patients and families) increased discussion rates and the health-care providers' confidence in providing up-to-date knowledge to patients. 26,36 The current CPG recommends providing patients and their families with up-to-date written or online educational resources, or both, in appropriate languages.…”

“…However, health-care providers reported that existing educational materials about fertility preservation are sometimes scarce and that the existing materials need to be improved and adapted to the patient population with CAYA cancer (moderate-quality evidence). [28][29][30][31][32][33][34] New studies have evaluated the effects of brochures for fertility preservation; 37,38 a decision aid for patients and families; 35 toolkits for health-care providers, including educational materials, checklist, referral forms, and handouts for patients; 26,39 and clinical decision support systems to assist clinical discussions and decision making. 36,40 These studies suggest that tools to support communication about infertility and fertility preservation have potential benefits to oncofertility care related to knowledge, empowerment, confidence levels, adherence to standards of care, and the making of informed decisions about fertility by patients and families (very low-quality evidence).…”

“…36,40 These studies suggest that tools to support communication about infertility and fertility preservation have potential benefits to oncofertility care related to knowledge, empowerment, confidence levels, adherence to standards of care, and the making of informed decisions about fertility by patients and families (very low-quality evidence). 26,[35][36][37][38][39][40] On the basis of the available data, it is unclear which intervention is most effective in communicating infertility risk and options for fertility preservation.…”

“…• Education materials (ie, information flyer) for patients with CAYA cancer and families was not significantly associated with use of cryopreservation (very low-quality evidence) 38 • Education materials (ie, information flyer) for patients with CAYA cancer and families improved consultation practice for fertility preservation (very low-quality evidence) 37 Effect of interventions for health-care providers, patients, and parents on health-care outcomes:…”