Determinants of Vitamin D Levels in Children and Adolescents with Down Syndrome

Stagi, Stefano; Lapi, Elisabetta; Romano, Silvia; Bargiacchi, Sara; Brambilla, Alice; Giglio, Sabrina; Seminara, Salvatore; Martino, Maurizio de

doi:10.1155/2015/896758

Cited by 43 publications

(51 citation statements)

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“…Regarding the body composition analysis, it can be observed that people with DS have less lean mass and higher percentages of body fat than controls. People with DS have several factors that, in theory, could lead to lower 25OHD levels, but we found no difference in 25OHD levels nor in the prevalence of hypovitaminosis D, defined as (25OHD < 20ng/ml (39%), which were similar to those of controls, and lower than that described in others studies that reported prevalence of hypovitaminosis D between 74 and 93% 23,24 . With respect to the markers of bone resorption, the β-CTX levels were similar in both groups.…”

Section: Discussioncontrasting

confidence: 82%

Diverging results of areal and volumetric bone mineral density in Down syndrome

et al. 2016

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Section: Discussioncontrasting

confidence: 82%

Diverging results of areal and volumetric bone mineral density in Down syndrome

et al. 2016

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“…The inverse association between 25(OH)D and DD appeared to be driven primarily by those with Down syndrome (trisomy 21). This could be due to reverse causation given that individuals with Down syndrome have been shown to have lower 25(OH)D concentrations [Stagi et al, ], which could result from increased susceptibility to genetically altered vitamin D metabolism and utilization or a greater need for vitamin D's immunomodulating effects [Guillot, Semerano, Saidenberg‐Kermanac'h, Falgarone, & Boissier, ] given increased neuroinflammation observed in Down syndrome [Wilcock & Griffin, ]. There is a lack of seasonality in Down syndrome [Stolwijk, Jongbloet, Zielhuis, & Gabreels, ], which might be expected if this were a causative association.…”

Section: Discussionmentioning

confidence: 99%

Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

et al. 2019

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Vitamin D appears essential for normal neurodevelopment and cognitive and behavioral function. We examined neonatal vitamin D in relation to the child's later diagnosis of autism spectrum disorder (ASD) or developmental delay (DD). Children aged 24-60 months enrolled in the population-based CHARGE case-control study were evaluated clinically for ASD (n = 357), DD (n = 134), or typical development (TD, n = 234) at the MIND Institute (Sacramento, CA) using standardized assessments. Total 25-hydroxyvitamin D (25[OH]D) was measured using sensitive isotope dilution liquid chromatography-tandem mass spectrometry in archived dried blood spots collected for the California Department of Public Health's Newborn Screening Program. Multinomial logistic regression was used to calculate ORs as measures of the associations between 25 nmol/L change in 25(OH)D and ASD and DD. Associations between 25(OH)D and scores on Mullen Scales of Early Learning and Vineland Adaptive Behavior Scales were assessed using robust linear regression. Effect modification was examined using stratified models and interaction product terms.Unadjusted mean (SD) 25(OH)D was lower for DD (73.2 [37.6]) than for TD (82.7 [39.3]) and ASD (80.1 [37.4]). After adjustment for maternal prepregnancy body mass index and education, a 25 nmol/L increase in total 25(OH)D was not associated with ASD (OR = 0.97; CI: 0.87-1.08) or DD (OR = 0.91; 95% CI: 0.78-1.06). Neonatal 25(OH)D was associated with significantly reduced ASD only in females (adjusted OR = 0.74; 95% CI: 0.55-0.99, P interaction = 0.03), and significantly reduced DD only in non-Hispanic white children (adjusted OR = 0.79; 95% CI: 0.63-0.98, P interaction = 0.11 for Hispanic, P interaction = 0.31 for other), driven by DD children with trisomy 21. This study provides evidence that neonatal vitamin D could be associated with ASD in females and with DD in non-Hispanic white children. Autism Res 2019, 12: 976-988.Lay Summary: Vitamin D appears essential for brain development and function. We examined neonatal total 25hydroxyvitamin D (25[OH]D) measured in dried blood spots in relation to later diagnoses of autism spectrum disorder (ASD) or developmental delay (DD) and related assessment scores. Higher neonatal 25(OH)D was associated with a 26% reduction in the odds for ASD only in females. After taking into account factors that could contribute to vitamin D status, a significant association with 21% reduced odds for DD was found only in non-Hispanic white children. Though results were nonsignificant overall, certain subgroups might benefit from higher neonatal vitamin D.

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“…In our group, the frequency of hypovitaminosis D was 40.7%. The influence of vitamin D on the body extends beyond the traditional understanding of its impact on bone health, and a recent study finding higher rates of hypovitaminosis D in a cohort with DS who have associated obesity and autoimmune disease is intriguing, highlighting the importance of further research (Stagi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Demographics and co‐occurring conditions in a clinic‐based cohort with Down syndrome in the United Arab Emirates

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Ahbabi

Dhaheri

et al. 2017

American J of Med Genetics Pt A

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The majority of studies describing demographics and co-occurring conditions in cohorts with Down syndrome come from regions outside of the Middle East, mainly from Europe and North America. This paper describes demographics and co-occurring conditions in a hospital-based cohort of individuals with Down syndrome living in the Middle Eastern country of the United Arab Emirates (UAE). The first dedicated Down syndrome clinic in the UAE was established in 2012 at Tawam Hospital in Al Ain. This paper describes a clinic-based cohort of 221 participants over 4 years from the Gulf Down Syndrome Registry, a new Down syndrome database and contact registry created at Tawam Hospital. Key demographic findings include mean maternal age of 37 years, among the highest described in the literature. Sixty-two percent of mothers are >35 years. Over 90% of mothers received post-natal diagnosis of Down syndrome. High sex ratio, parental consanguinity, and large family size also characterize the group. The spectrum of many co-occurring conditions mirrors that of previously described populations, with some notable differences. Cardiovascular malformations are well represented, however, atrioventricular canal is not the most common. Genitourinary conditions are common, as evidenced by 12% of males with hypospadias and 15% with undescended testes. Glucose-6-phosphate dehydrogenase deficiency, alpha thalassemia trait, hypovitaminosis D, and dental caries are common in our cohort. This study describes a large hospital-based group with Down syndrome presenting to a new dedicated Down syndrome clinic in the UAE, highlighting unique demographic and co-occurring conditions found in that population.

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Determinants of Vitamin D Levels in Children and Adolescents with Down Syndrome

Cited by 43 publications

References 60 publications

Diverging results of areal and volumetric bone mineral density in Down syndrome

Diverging results of areal and volumetric bone mineral density in Down syndrome

Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

Demographics and co‐occurring conditions in a clinic‐based cohort with Down syndrome in the United Arab Emirates

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