Determinants of weight maintenance in women after diet-induced weight reduction

Westerterp-Plantenga, Margriet S.; Kempen, Kitty P.; Saris, Wim H. M.

doi:10.1038/sj.ijo.0800536

Cited by 126 publications

(92 citation statements)

References 13 publications

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“…In contrast to our results and others [17], similar trials performed in non-diabetic, obese individuals have reported long-term weight loss principally due to reductions in fat mass [21,22]. This preferential loss of LBM in Type 2 diabetes may be due to a higher whole-body proteolytic rate associated with moderate hyperglycaemia [23].…”

Section: Discussioncontrasting

confidence: 98%

Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with Type 2 diabetes: one-year follow-up of a randomised trial

et al. 2004

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Aims/hypothesis. This study compared the long-term weight loss and health outcomes at 1-year follow-up, after a 12-week intensive intervention consisting of two low-fat, weight-loss diets, which differed in protein content. Methods. We randomly assigned 66 obese patients (BMI: 27-40 kg/m 2 ) with Type 2 diabetes to either a low-protein (15% protein, 55% carbohydrate) or high-protein diet (30% protein, 40% carbohydrate) for 8 weeks of energy restriction (~6.7 MJ/day) and 4 weeks of energy balance. Subjects were asked to maintain the same dietary pattern for a further 12 months of follow-up. Results. The study was completed by 38 of the subjects, with equal dropouts in each group. At Week 64, weight reductions against baseline were −2.2±1.1 kg (low protein) and −3.7±1.0 kg (high protein), p<0.01, with no diet effect. Fat mass was not different from baseline in either group. At Week 12, both diets reduced systolic and diastolic blood pressure by 6 and 3 mm Hg respectively, but blood pressure increased more with weight regain during follow-up in the lowprotein group (p≤0.04). At Week 64, both diets significantly increased HDL cholesterol and lowered C-reactive protein concentrations. There was no difference in the urinary urea : creatinine ratio at baseline between the two groups, but this ratio increased at Week 12 (in the high-protein group only, p<0.001, diet effect), remaining stable during follow-up in both diets. Conclusions/interpretation. A high-protein weightreduction diet may in the long term have a more favourable cardiovascular risk profile than a lowprotein diet with similar weight reduction in people with Type 2 diabetes.

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Section: Discussioncontrasting

confidence: 98%

Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with Type 2 diabetes: one-year follow-up of a randomised trial

et al. 2004

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“…The success of weight loss maintenance has been shown to be dependent on an increase in dietary restraint during weight reduction phase. [9][10][11] In our previous study, 5 the weight loss in obese women in response to 4-week VLCD treatment combined with cognitive behavioral therapy was associated with a significant increase in restraint score and a significant decrease in disinhibition and hunger scores of the EI, as well as with a significant decrease in the Beck depression score.…”

Section: Discussionmentioning

confidence: 80%

“…The relationship between EI scores and weight change has been evaluated in the dietary treatment of obesity, 7 the treatment of severely obese patients by bariatric surgery 8 as well as in weight maintenance after diet-induced weight reduction. [9][10][11] Psychological and behavioral predictors of weight loss have also been evaluated in the context of pharmacological treatments for obesity, including fenfluramine, phentermine, mazindol and caffeine plus ephedrine, 12 usually administered as combined therapy (fenfluramine þ phentermine, fenfluramine þ mazindol). Baseline scores of two items of the EI, perceived hunger and dietary restraint, appeared important factors in the prediction of weight loss after 6 and 12 months of drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Psychobehavioral and nutritional predictors of weight loss in obese women treated with sibutramine

et al. 2004

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OBJECTIVE:To reveal whether baseline body mass index (BMI), and psychobehavioral and nutritional markers were significant predictors of the change in BMI observed after 4 and 12 months in obese women enrolled in a weight reduction program, including low-energy diet, increased physical activity, cognitive behavior therapy and sibutramine. The impact of changes in psychobehavioral and nutritional markers observed after 4 and 12 months of treatment on BMI changes was also investigated. DESIGN: During a double-blind placebo-controlled 4-month period, subjects received either sibutramine (10 mg/day) or placebo. Then, an open phase with sibutramine administered to all patients continued until month 12. SUBJECTS: In total, 80 obese women (age: 43.9710.6 y, BMI: 36.774.8 kg/m 2 ). MEASUREMENTS: The dependent variable was change in BMI while baseline BMI, mode of treatment, the Beck depression score, the three items (dietary restraint, disinhibition and perceived hunger) of the Eating Inventory (EI), energy and macronutrient intakes were independent variables. At 1-week dietary records were analyzed using a computer software for assessing energy and macronutrient intake. RESULTS: Multiple regression analysis revealed that the BMI loss at month 4 was significantly influenced by mode of treatment and initial BMI, whereas a borderline negative relationship was observed with the baseline restraint score. Baseline BMI, depression score, restraint score and total energy intake predicted weight loss at month 12. These predictive variables accounted for 43.8% of the variance in BMI loss at 12 months. When relationships between the BMI loss and changes in all included psychobehavioral and nutritional parameters were considered after 12 months of treatment, a drop in the disinhibition score of the EI appeared the only significant factor affecting the BMI decrease. CONCLUSIONS: Our results suggest that psychobehavioral and nutritional characteristics can be used as predictors of weight loss in response to a comprehensive weight management program including pharmacological treatment with sibutramine.

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“…The risks associated with many of these comorbid conditions may be reduced with modest weight loss. Weight control methods often produce short-term success, but sustained weight maintenance is difficult to reach (Westerterp-Plantenga et al, 1998;. Moreover, the increasing prevalence of obesity (Kuczmarski et al, 1994) requires preventive treatments of obesity.…”

Section: Introductionmentioning

confidence: 99%

The effect of grape-seed extract on 24 h energy intake in humans

2004

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Objective: Since grape-seed extract has been shown to stimulate lipolysis in vitro and reduce food intake in rats, we assessed the efficacy of grape-seed extract with respect to energy intake (EI) and satiety. Design: In a randomized, placebo-controlled, double-blind, cross-over study, 51 subjects (age 18-65 y, body mass index 22-30 kg/m 2 ) ate an ad libitum lunch and dinner twice in the University Restaurant for 3 days. Standard breakfasts and snacks were provided. Supplements were taken 30-60 min prior to each meal. Results: In the total study population, no difference in 24 h EI was found between the grape-seed extract and placebo. However, in the subgroup of subjects (n¼23) with an energy requirement Zthe median of 7.5 MJ/day, EI was reduced by 4% (DEI 352.1 kJ/24 h, P¼0.05) after grape-seed extract compared to placebo treatment. Meanwhile, there were no significant differences in macronutrient composition, attitude towards eating, satiety, mood or tolerance. Conclusions: Grape seed reduced 24 h EI, with on average 4% in subjects who had an energy requirement Z7.5 MJ/day, without further effects on satiety, mood or tolerance. These findings suggest that grape seed could be effective in reducing 24 h EI in normal to overweight dietary unrestrained subjects, and could, therefore, play a significant role in body-weight management.

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Determinants of weight maintenance in women after diet-induced weight reduction

Cited by 126 publications

References 13 publications

Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with Type 2 diabetes: one-year follow-up of a randomised trial

Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with Type 2 diabetes: one-year follow-up of a randomised trial

Psychobehavioral and nutritional predictors of weight loss in obese women treated with sibutramine

The effect of grape-seed extract on 24 h energy intake in humans

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