Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust

Leppänen, Hanna; Täubel, Martin; Roponen, Marjut; Vepsäläinen, Asko; Rantakokko, Panu; Pekkanen, Juha; Nevalainen, Aino; Hyvärinen, Anne

doi:10.1111/ina.12141

Cited by 9 publications

(2 citation statements)

References 52 publications

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“…These can be measured at low levels by gas chromatography with mass spectral detection. Accordingly, presence of bacterial 3-hydroxy fatty acids in environmental samples has been useful as an indication of endotoxin contamination (193). Quantitation of these fatty acids in serum would represent total bacterial exposures while the LAL reactivity assay represents only free LPS that is dissociated from the bacterial cell wall (194).…”

Section: Biomarkers Of Systemic Bacterial Exposuresmentioning

confidence: 99%

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Djurić

2017

Translational Research

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Obesity increases the risks of many cancers. One important mechanism behind this association is the obesity-associated pro-inflammatory state. Although the composition of the intestinal microbiome undoubtedly can contribute to the pro-inflammatory state, perhaps the most important aspect of host-microbiome interactions is host exposure to components of intestinal bacteria that stimulate the inflammatory reactions. Systemic exposures to intestinal bacteria can be modulated by dietary factors by altering both the composition of the intestinal microbiota as well as absorption of bacterial products from the intestinal lumen. In particular, high fat and high energy diets have been shown to facilitate absorption of bacterial lipopolysaccharide (LPS) from intestinal bacteria. Biomarkers of bacterial exposures that have been measured in blood include LPS-binding protein, sCD14, fatty acids characteristic of intestinal bacteria and immunoglobulins specific for bacterial LPS and flagellin. The optimal strategies to reduce these pro-inflammatory exposures, whether by altering diet composition, avoiding a positive energy balance or reducing adipose stores, likely differ in each individual. Biomarkers that assess systemic bacterial exposures therefore should be useful to optimize and personalize preventive approaches for individuals and groups with specific characteristics, and to gain insight into the possible mechanisms involved with different preventive approaches.

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Section: Biomarkers Of Systemic Bacterial Exposuresmentioning

confidence: 99%

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Djurić

2017

Translational Research

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“…A number of housing and lifestyle characteristics, including the type of dwelling, affects the quantity and diversity of microbial exposure in home environments (71,72). Examination of house dust has provided valuable information of the exposure to microbes in different home environments.…”

Section: Home and Its Surroundingmentioning

confidence: 99%

Helsinki alert of biodiversity and health

et al. 2015

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Urban living in built environments, combined with the use of processed water and food, may not provide the microbial stimulation necessary for a balanced development of immune function. Many chronic inflammatory disorders, including allergic, autoimmune, metabolic, and even some behavioural disorders, are linked to alteration in the human commensal microbiota. Sedentary lifestyle is associated with reduced exposure to a broad spectrum of environmental micro-organisms and surplus energy balance, both risk factors of chronic inflammatory disorders. According to the Biodiversity Hypothesis, an environment with diverse macrobiota and microbiota modifies and enriches the human microbiota, which in turn is crucial in the development and maintenance of appropriate immune function. These issues were discussed in the symposium Chronic Inflammation, Lifestyle and Environment , held in Helsinki, 20 - 22 August 2014, under the sponsorship of the Yrjo Jahnsson Foundation. This paper briefly outlines the recent findings in the context of the environment, lifestyle, and health; discusses the forces that undermine immune tolerance in urban environments; and highlights the possibilities to restore broken immune tolerance among urban dwellers, summarizing the main messages in four statements and calling for actions to combat major public health threats

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