Gas turbine technology has advanced significantly during the last twenty years. The advancement in materials technology, new coatings, and novel cooling techniques are driving the expansion. Material selection is critical since turbomachinery design is complicated, and material performance is directly connected to efficiency. The materials should be able to withstand high vibrations, high temperature, and pressure. In this work, the maximum stress and the deformation induced due to pressure were determined to study the vibrational response, mode shapes, and natural frequencies. Four different materials have been considered, namely Inconel 617, Titanium alloy, Rhenium alloy, and Nimonic 80A. A suitable material for a gas turbine blade was suggested after analyzing these materials. The 3D CAD model is modeled in CATIA V5 and analysis is carried out using FEM-based software ANSYS