Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K

Yu, Chuanping; Sun, Xinyuan; Wang, Yan; Du, Shichao; Shen, Liang; Sun, Qilei

doi:10.1021/acsomega.1c06468

Cited by 14 publications

(15 citation statements)

References 37 publications

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“…The CNIBS / R–K model , is the most widely used equation for predicting solubility in binary liquids. This model is doing an excellent job of correlating solubility data to solvent composition, but that does not account for temperature.…”

Section: Results and Discussionmentioning

confidence: 99%

Solubility Modeling of a Bupivacaine Hydrochloride in Various Solvents over a Wide Temperature Range

et al. 2023

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In the present work, the solubility parameters of the local anesthetic drug bupivacaine hydrochloride (BH) were measured. The pure solvents under study were methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, dimethylformamide (DMF), acetic acid, and water. Two binary solvent systems, namely, methanol + water and ethanol + water, were also used to determine the solubility. The experimental solubility of the BH was obtained by the gravimetric method over a series of temperatures (293.15−333.15 K) in different mono and binary solvents under atmospheric pressure. Experimental results reveal the dependence of solubility on temperature. The experimental mole fraction solubility was further correlated with theoretical models such as the Apelblat, λh, Van't Hoff, modified Jouyban−Acree, and CNIBS/R−K models. The small values of RAD and RMSD indicated that the data are in good agreement with experimental data. The data of solubility can be applied in the fields of production, purification, crystallization, and separation of BH.

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Section: Results and Discussionmentioning

confidence: 99%

Solubility Modeling of a Bupivacaine Hydrochloride in Various Solvents over a Wide Temperature Range

et al. 2023

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“…When N is equal to 2, x 3 0 = 1 – x 2 0 , and eq is finally expressed as eq by linking the Jouyban–Acree model with the Modified Apelblat model (eq ). In the formula, A 1 – A 9 are parameters of the Modified Jouyban–Acree model , and are listed in Table .…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Measurement and Model Correlation of N,N′-Oxalyldiglycine in Eleven Pure Solvents and a Binary Solvent from 293.15 to 333.15 K

Huang,

Wang,

Jiang

et al. 2023

J. Chem. Eng. Data

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The solubility of N,N’-oxalyldiglycine (OG) in 11 pure solvents, including methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, acetonitrile, ethyl acetate, tetrahydrofuran (THF), water, N,N’-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO), and a binary solvent system composed of DMSO and water was measured by a dynamic laser monitoring method with the temperature ranging from 293.15 to 333.15 K. Results of these experiments demonstrated that the solubility of OG in all pure solvents increases with rising temperature. The highest solubility appeared in DMSO while the lowest solubility appeared in ethyl acetate. Besides, the mole fraction solubility of OG in binary solvents increases with increasing content of DMSO. Furthermore, the experimental solubility of OG in pure solvents was correlated with the modified Apelblat, Van’t Hoff, λh, and Wilson models. Four models (Van’t Hoff, CNIBS/R–K, modified Jouyban–Acree, and Wilson) were used for the binary solvents. The Van’t Hoff model best correlates with the experimental values in pure and binary solvents, and the calculated values by the Wilson model have a large deviation from the experimental values.

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“…The Buchowski–Ksiazaczak λh equation can reflect the relationship between solubility, solvent activity, and temperature. − The Buchowski–Ksiazaczak λh equation is defined as eq : ln ( 1 + λ 1 − x 1 x 1 ) = λ h ( 1 T − 1 T m ) where λ and h represent the model parameters in the equation, T represents the absolute temperature of solubility experiment, and T m represents the melting temperature.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Measurement and Correlation of Solubility of Dicyandiamide in Five Binary Solvents from 283.15 to 323.15 K

Pan,

Du,

Wang

et al. 2023

J. Chem. Eng. Data

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The solid−liquid equilibrium solubility of dicyandiamide (DCD) in five kinds of binary solvent mixtures (water + ethanol, water + n-propanol, water + N,Ndimethylformamide (DMF), water + acetonitrile, and DMF + ethyl acetate) at T = (283.15−323.15) K was determined by gravimetric method. The solubility of DCD in the five groups of binary mixed solvents increases with the increase of temperature. In the mixed solvent of water + DMF, the solubility of DCD decreases monotonically with the increase in water content. And in the mixed solvent of DMF + ethyl acetate, the solubility of DCD monotonically increases with the increase of DMF content. Among the other three mixed solvents, with the increase of the water component, the solubility of DCD first increases and then decreases after reaching the peak. The maximum solubility value in water + ethanol, water + n-propanol, and water + acetonitrile is reflected when the water ratio is 0.6. The modified Apelblat model, van't Hoff model, λh model, Apelblat−Jouyban−Acree model, and the nonrandom two-liquid model were used to correlate the solubility data. The results show that the modified Apelblat model has the best correlation with the solubility of DCD.

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Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K

Cited by 14 publications

References 37 publications

Solubility Modeling of a Bupivacaine Hydrochloride in Various Solvents over a Wide Temperature Range

Solubility Modeling of a Bupivacaine Hydrochloride in Various Solvents over a Wide Temperature Range

Solubility Measurement and Model Correlation of N,N′-Oxalyldiglycine in Eleven Pure Solvents and a Binary Solvent from 293.15 to 333.15 K

Measurement and Correlation of Solubility of Dicyandiamide in Five Binary Solvents from 283.15 to 323.15 K

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