Determination and Correlation of Solubility of Quetiapine Fumarate in Nine Pure Solvents and Two Aqueous Binary Solvents

Jin, Shasha; Du, Shichao; Liu, Yumin; Han, Dandan; Li, Zhenfang; Li, Kangli; Gong, Junbo

doi:10.1021/acs.jced.7b00518

Cited by 25 publications

(15 citation statements)

References 25 publications

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“…The crystal forms of MET·HCl were detected by the PXRD technique. − We tested the remaining solid after shaking the crystal for 12 h in nine solvents such as water, methanol, ethanol, acetone, isopropanol, water + methanol, water + ethanol, water + acetone, and water + isopropanol. The experimental results are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Sun

et al. 2021

J. Chem. Eng. Data

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The solubility of form A metformin hydrochloride (MET·HCl) in water, methanol, ethanol, water + methanol, water + ethanol, water + acetone, and water + isopropanol at the temperatures ranging from 283.15 to 323.15 K was determined by gravimetric method. The experimental results show that the solubility increases with the increase of temperature and the initial water content of the binary solvents. The order of solubility in the four aqueous solvent mixtures is water + methanol > water + ethanol > water + isopropanol > water + acetone, which is mainly contributed by the hydrogen bond interactions. The modified Apelblat model, CNIBS/R–K model, and Apelblat–Jouyban–Acree model were used to correlate the solubility data. The results show that the Apelblat model can correlate the solubility of four binary solvents best, and all average relative deviations are less than 6%.

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Section: Resultsmentioning

confidence: 99%

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Sun

et al. 2021

J. Chem. Eng. Data

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“…In binary mixed solvents, the activity coefficient γ i can be described as eqs – where i ≠ j , Δ g ij is the parameter that is related to the Gibbs energy of intermolecular interaction, τ ij is another parameter associated with the nonrandomness of the solution, and α ij is an adjustable parameter that varies between 0 and 1.…”

Section: Thermodynamic and Correlation Modelsmentioning

confidence: 99%

Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K

Wang

Zhou

et al. 2020

J. Chem. Eng. Data

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The solubility of aspirin in four binary solvents of ethanol + methyl cyclohexane, n-propanol + methyl cyclohexane, acetone + methyl cyclohexane, and ethyl acetate + methyl cyclohexane was measured by the gravimetric method at temperatures from T = 283.15 to 323.15 K. The solubility of aspirin in all mixed solvents increased with the increase of temperature and decreased with the increase of the mole fraction of methyl cyclohexane. The solubility data of aspirin was correlated by the CNIBS/R–K model, Jouyban–Acree model, and nonrandom two-liquid (NRTL) model. Also, the average relative deviation (ARD) of all models was lower than 5%. The results indicated that these models fit the solubility data well. Besides, the mixing thermodynamic properties of aspirin in four binary solvent mixtures were investigated on the basis of the solubility data and the NRTL model. The results showed that the mixing process of aspirin is a spontaneous process and follows the increase of entropy principle.

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“…The modified Apelblat equation [23][24][25] is usually used to determine the correlation between solubility and temperature. It is deduced from the well-known Clausius-Clapeyron equation.…”

Section: Modified Apelblat Equationmentioning

confidence: 99%

Solubilities of 2,6‐Diamino‐3,5‐dinitropyrazine‐1‐oxide in the Binary Mixtures of DMSO+H₂O, DMF+H₂O and NMP+H₂O in the Temperature Range from 293.15 to 323.15 K under the Atmospheric Pressure

Wang

Jin

et al. 2019

Propellants Explo Pyrotec

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Recrystallization is usually required for the application of 2,6‐Diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) as an energy material due to its poor crystal morphology. The study of its solubilities in binary solvent mixtures can provide primary support for optimizing the recrystallization and spheroidization conditions of LLM‐105. In the current work, the solubilities of LLM‐105 in the binary mixtures of dimethyl sulfoxide (DMSO)+H2O, N,N‐dimethyl‐formamide (DMF)+H2O and 1‐methyl‐2‐pyrrolidone (NMP) +H2O were measured by the gravimetric method in the temperature range from 293.15 K to 323.15 K under the atmospheric pressure. The results suggest that the solubility of LLM‐105 increases with the increase of temperature and the concentration of the solvent. The experimental data were then fitted with the modified Apelbalt equation, (CNIBS)/Redlich‐Kister equation and Jouyban‐Acree equation. All models fit the experimental data well, indicating that they can be used to predict the solubilities of LLM‐105 in the binary solvent mixtures. The thermodynamic parameters of the dissolution including enthalpy, standard entropy and Gibbs energy were calculated from the experimental data. It was found that the dissolutions of LLM‐105 in all test solvents were endothermic.

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Determination and Correlation of Solubility of Quetiapine Fumarate in Nine Pure Solvents and Two Aqueous Binary Solvents

Cited by 25 publications

References 25 publications

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K

Solubilities of 2,6‐Diamino‐3,5‐dinitropyrazine‐1‐oxide in the Binary Mixtures of DMSO+H₂O, DMF+H₂O and NMP+H₂O in the Temperature Range from 293.15 to 323.15 K under the Atmospheric Pressure

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Determination and Correlation of Solubility of Quetiapine Fumarate in Nine Pure Solvents and Two Aqueous Binary Solvents

Cited by 25 publications

References 25 publications

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K

Solubilities of 2,6‐Diamino‐3,5‐dinitropyrazine‐1‐oxide in the Binary Mixtures of DMSO+H2O, DMF+H2O and NMP+H2O in the Temperature Range from 293.15 to 323.15 K under the Atmospheric Pressure

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Solubilities of 2,6‐Diamino‐3,5‐dinitropyrazine‐1‐oxide in the Binary Mixtures of DMSO+H₂O, DMF+H₂O and NMP+H₂O in the Temperature Range from 293.15 to 323.15 K under the Atmospheric Pressure