Determination and occurrence of natural and synthetic glucocorticoids in surface waters

Shen, X. Y.; Chang, Hong; Sun, Yifeng; Wan, Yi

doi:10.1016/j.envint.2019.105278

Cited by 68 publications

(22 citation statements)

References 53 publications

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“…In addition, it was found that C-21 esters (21-CRLA and 21-CRLV) were prone to decomposition compared to C-17 esters (17-CRLA and 21-CRLV). ose findings are different from the recovery results reported by our recent study [11]. at study found C-17 esters were prone to hydrolysis in pure water, even under neutral conditions.…”

Section: Kinetics Of Steroid Biodegradationcontrasting

confidence: 98%

“…e presence of the four groups of steroid hormones and, in particular, estrogens in surface waters has been reported in multiple studies, and their concentrations were in the range of pg/L to several hundreds of ng/L [6][7][8][9][10][11]. Wastewater treatment plants (WWTPs) such as municipal and livestock WWTPs play a crucial role in restricting steroid hormones from entering riverine and coastal environments [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Aerobic Biodegradation of Four Groups of Steroid Hormones in Activated Sludge

Zhang

Luo

Chang

2020

Journal of Chemistry

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Steroid hormones in the environment have obtained considerable attention, as they can be harmful to aquatic organisms at very low concentrations. An analytical method was developed for simultaneously monitoring four estrogens, seven androgens, seven progestogens, and eleven glucocorticoids in a single water sample using liquid chromatography-electrospray tandem mass spectrometry. Laboratory studies were then performed to investigate the aerobic biodegradation of 29 steroids belonging to the four groups. The degradation of target steroids followed first-order reaction kinetics, and the degradation half-life (t1/2) of estrogens, androgens, progestogens and glucocorticoids was 1.2–8.7 h, 0.3–1.3 h, 1.4–7.7 h, and 1.4–23.1 h, respectively. Most of the esterified glucocorticoids were more persistent than the parent compounds, but the t1/2 for halogenated glucocorticoids was longer than that of their esterified compounds. In addition, C-21 ester glucocorticoids were more prone to decomposition than C-17 esters. Hydrolysis did not significantly affect the decomposition of esterified steroids.

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Section: Kinetics Of Steroid Biodegradationcontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Aerobic Biodegradation of Four Groups of Steroid Hormones in Activated Sludge

Zhang

Luo

Chang

2020

Journal of Chemistry

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“…The effects of the presence of DEX in the environment are already reported in literature ( DellaGreca et al, 2004 ; Lalone et al, 2012 ; Lorenz et al, 2009 ; Margiotta-Casaluci et al, 2016 ; Shen et al, 2020 ). Due to its potential of affecting the development, reproduction, growth and expression of mRNA of amphibians and fish, the presence of this chemical in water can also cause toxicity to aquatic organisms.…”

Section: Resultsmentioning

confidence: 75%

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

Nippes

Macruz

Silva

et al. 2021

Process Safety and Environmental Protection

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“…2,3 The disruption of corticosteroid signaling pathways by corticosteroids (CSs), another subclass of steroid hormones, has been overlooked. 4 Corticosteroids are synthesized by the adrenal cortex in nonmammals and are commonly used as adjuvant therapy for acute respiratory distress syndrome by many clinicians because of their perceived anti-inflammatory effects. 5,6 They all contain the same cyclopentanophenanthrene ring and atomic numbering system as cholesterol (Fig.…”

Section: Introductionmentioning

confidence: 99%