Determination and Thermodynamic Modeling of Solid–Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures

Abstract

Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in ethyl acetate, acetonitrile, methyl isobutyl ketone, ethanol, methanol, and in the (ethanol + ethyl acetate) mixtures between 278.15 and 328.15 K. A group of thermodynamic models were selected such as the Jouyban−Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodynamic properties of esomeprazole sodium using the van't Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.

Determination and Analysis of Solubility of l-Prolinamide in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

“…The combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R–K) Model can be used to describe the changing trends between the solubility and temperature of l -prolinamide in different binary solvent mixtures. − The equation is as follows …”

Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Buprofezin in Pure and Binary Organic Solvents

“…The solubility of buprofezin has been consistent with the following modified Apelblat model under temperature changes: where T stands for the absolute kelvin temperature, A , B , and C represent the model parameters, and x represents the mole fraction solubility of buprofezin in the solvent. The factors A and B represent the variation in the solution activity coefficient and take an indication of the effect of non-ideal solution of solute solubility, and the factor C represents the temperature effect on the fusion enthalpy, which is a deviation from heat capacity (Δ C p ) . The regression curve parameters of the modified Apelblat model are listed in Table .…”

“…The changing trends of solubility against different ratios of isopropanol under isothermal conditions are described by the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model, ,, which is one of the theoretical models for calculating the solute solubility in binary solvents and is represented in eq : where x represents the mole fraction solubility of buprofezin, x A and x B represent the initial mole fraction compositions of the binary solvents when the solute was not added, and X A and X B represent the saturated mole solubility of buprofezin in pure ethyl acetate and methanol (or acetonitrile), respectively. S i is the model constant, and N can be equal to 0, 1, 2, and 3.…”

Experimental Determination and Thermodynamic Models for Solid–Liquid Equilibrium of 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide in Pure and Binary Solvent Mixtures for T = (278.15–328.15) K

“…The Jouyban–Acree model is widely used to describe the solubility of a solute with the variation of both temperature and the initial composition of binary solvent mixtures. − This equation is expressed as eq where J i is the model constant, T is the absolute temperature, and the other symbols have the same meaning as in eq . In these works, we expressed the variation in ln X A and ln X B values in eq as or ( N = 2) where the A 1 , B 1 , A 2 , B 2 , and J i terms are the model constants, which are listed in Table .…”