Determination of 117 endocrine disruptors (EDCs) in water using SBSE TD–GC-MS/MS under the European Water Framework Directive

Canlı, Oltan; Çetintürk, Kartal; Olgun, Elmas Eva Öktem

doi:10.1007/s00216-020-02553-4

Cited by 15 publications

(4 citation statements)

References 18 publications

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“…Two years prior, a study on Sakarya River water samples in Turkey's Marmara province, utilizing 100 mL water for extraction, determined LOD values for various substances, revealing analytical sensitivity. The study indicated that PAHs were the primary pollutants, hinting at potential industrial activities, while pesticides and phenol compounds likely originated from agriculture and soil runoff [87].…”

Section: Assessing Pesticide Levels and Techniques For Their Detectionmentioning

confidence: 99%

Investigative Approaches for Pollutants in Water: Aligning with Water Framework Directive Maximum Allowable Concentrations

Koljančić,

Špánik

2023

Water

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In the wake of rapid advancements in the pharmaceutical, food, and agricultural industries, the environment faces an increasing influx of diverse compounds, both intentionally and unintentionally released. These compounds fall into two categories: persistent and emerging pollutants. Persistent pollutants, characterized by their resistance to degradation and potential to accumulate in the environment, pose serious ecological threats. The Water Framework Directive (WFD) plays a pivotal role in monitoring and regulating these substances. This review discusses various contemporary analytical approaches to determine problematic substances, including benzo(a)pyrene, cypermethrin, dichlorvos, heptachlor, and heptachlor epoxide, aligning with the priorities outlined in the 2013 WFD classification. This review focuses on diverse water sampling methods, sample preparation techniques, and analytical methods, encompassing chromatographic, spectroscopic, and electrochemical approaches, with the primary goal of achieving the requirement laid on analytical methods used for the determination of maximum allowable concentrations defined in the WFD. Chromatographic methods, utilizing diverse mass spectrometers, have achieved detection limits as low as 10−6 μg/L, while modern electroanalytical techniques reach levels as low as 10−13 μg/L, reflecting an ongoing collective effort to enhance monitoring and safeguard the health of aquatic ecosystems. From sampling methods, large-volume sampling and passive sampling devices have been shown to be a cost-effective and modern solution, addressing limitations in traditional sampling methods, even if both of them face important pros and cons in terms of quantitative analysis.

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Section: Assessing Pesticide Levels and Techniques For Their Detectionmentioning

confidence: 99%

Investigative Approaches for Pollutants in Water: Aligning with Water Framework Directive Maximum Allowable Concentrations

Koljančić,

Špánik

2023

Water

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“…Over time, the residual BPA present in these products, as well as the BPA released through the hydrolysis of polymer ester bonds, can gradually enter the environment, leading to significant effects on both humans and other organisms [12]. With the continuous improvement in living standards, the widespread use of plastic products in daily life [13,14], has drastically increased making people's exposure to BPA, leading to a higher likelihood of its residues in these materials entering the human body [15,16]. Currently, several traditional methods are used for BPA detection, including GC, HPLC-MS, GC-MS, and LC-secondary MS/MS [17][18][19][20], which offer high detection sensitivity, good selectivity, and rapid detection [21].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of molecularly imprinted resin via controlled polymerization applied in the enrichment of bisphenol A for plastic products

Wang

Bai

et al. 2023

J of Separation Science

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The addition of bisphenol A has been frequently used in industrial manufacturing because it imparts plastic products with characteristics such as transparency, durability, and excellent impact resistance. However, its widespread use raises concerns about potential leakage into the surrounding environment, which poses a significant risk to human health. In this study, molecularly imprinted polymers with specific recognition of bisphenol A were synthesized through surface-initiated atom transfer radical polymerization using poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) as the substrate, bisphenol A as the template molecule, 4-vinylpyridine as the monomer, and ethylene glycol dimethacrylate as the cross-linker. The bisphenol A adsorption capacity was experimentally investigated, and the kinetic analysis of the molecularly imprinted polymers produced an adsorption equilibrium time of 25 min, which is consistent with the pseudo-second-order kinetic model. The results of the static adsorption experiments exhibited consistency with the Langmuir adsorption model, revealing a maximum adsorption capacity of 387.2 μmol/g. The analysis of molecularly imprinted polymers-enriched actual samples using high-performance liquid chromatography demonstrated excellent selectivity for bisphenol A, with a linear range showing 93.4%-99.7% recovery and 1.1%-6.4% relative standard deviation, demonstrating its high potential for practical bisphenol A detection and enrichment applications.

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“…Advanced analytical methodologies allow the identification of a wide variety of contaminants in environmental samples. Mass spectrometry (MS) coupled to gas ( Canlı et al, 2020 ;Sotão Neto et al, 2020 ) and liquid chromatography ( Fonseca et al, 2019 ;Tian et al, 2020 ) are nowadays the gold-standards for the identification and quantification of organic contaminants in environmental samples ( Pérez and Barceló, 2007 ). In the last few years, Ultra-High Performance Liquid chromatography (UHPLC) coupled to tandem MS (MS/MS), or to high-resolution MS (HRMS), have been widely used for accurate quantification of organic micropollutants ( Boix et al, 2014 ;Gracia-Lor et al, 2011 ), or for widescope screening ( Guardian et al, 2021 ;Hernández et al, 2015bHernández et al, , 2015Llorca et al, 2021 ;Lotfi Khatoonabadi et al, 2021 ), respectively.…”

Section: Introductionmentioning

confidence: 99%

Wide-scope screening of pharmaceuticals, illicit drugs and their metabolites in the Amazon River

Fabregat‐Safont¹,

Ibáñez²,

Bijlsma³

et al. 2021

Water Research

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Only a limited number of households in the Amazon are served by sewage collection or treatment facilities, suggesting that there might be a significant emission of pharmaceuticals and other wastewater contaminants into freshwater ecosystems. In this work, we performed a wide-scope screening to assess the occurrence of pharmaceuticals, illicit drugs and their metabolites in freshwater ecosystems of the Brazilian Amazon. Our study included 40 samples taken along the Amazon River, in three of its major tributaries, and in small tributaries crossing four important urban areas (Manaus, Santarém, Macapá, Belém). More than 900 compounds were investigated making use of target and suspect screening approaches, based on liquid chromatography coupled to high-resolution mass spectrometry with ion mobility separation. Empirical collision-cross section (CCS) values were used to help and confirm identifications in target screening, while in the suspect screening approach CCS values were predicted using Artificial Neural Networks to increase the confidence of the tentative identification. In this way, 51 compounds and metabolites were identified. The highest prevalence was found in streams crossing the urban areas of Manaus, Macapá and Belém, with some samples containing up to 30 -40 compounds, while samples taken in Santarém showed a lower number (8 -11), and the samples taken in the main course of the Amazon River and its tributaries contained between 1 and 7 compounds. Most compounds identified in areas with significant urban impact belonged to the analgesics and antihypertensive categories, followed by stimulants and antibiotics. Compounds such as caffeine, cocaine and its metabolite benzoylecgonine, and cotinine (the metabolite of nicotine), were also detected in areas with relatively low anthropogenic impact and showed the highest total prevalence. This study supports the need to improve the sanitation system of urban areas in the Brazilian Amazon and the development of follow-up studies aimed at quantifying exposure levels and risks for Amazonian freshwater biodiversity.

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Determination of 117 endocrine disruptors (EDCs) in water using SBSE TD–GC-MS/MS under the European Water Framework Directive

Cited by 15 publications

References 18 publications

Investigative Approaches for Pollutants in Water: Aligning with Water Framework Directive Maximum Allowable Concentrations

Investigative Approaches for Pollutants in Water: Aligning with Water Framework Directive Maximum Allowable Concentrations

Fabrication of molecularly imprinted resin via controlled polymerization applied in the enrichment of bisphenol A for plastic products

Wide-scope screening of pharmaceuticals, illicit drugs and their metabolites in the Amazon River

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