Determination of 234U/238U, 235U/238U and 236U/238U isotope ratios in urine using sector field inductively coupled plasma mass spectrometry

Xiao, Ge; Jones, Robert L.; Saunders, David; Caldwell, Kathleen L.

doi:10.1093/rpd/ncu023

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…Aridus II (Cetac, U.S.A.) as a sample introduction system can enhance analyte sensitivity and significantly reduce the occurrence of solvent-based interference by effectively separating analytes and solvent. , Importantly, a 15 L trap bottle is used to condense the solvent vapor carried in the “sweep gas” waste stream coming out of the heated chambers of the Aridus II device. Due to the relatively high and temporally variable temperature of the trap bottle, its pressure is very susceptible to external conditions such as indoor temperature and air pressure.…”

Section: Methodsmentioning

confidence: 99%

High-Sensitivity Measurement of Cr Isotopes by Double Spike MC-ICP-MS at the 10 ng Level

Zhu

Wang

et al. 2019

Anal. Chem.

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High-sensitivity and high-precision (2 SD ≤ 0.06‰) measurement of chromium (Cr) isotopes at the 10 ng level was successfully carried out using double spike multiple-collector inductively couple plasma mass spectrometry (MC-ICP-MS). To enhance the signal sensitivity and stability, the Aridus II desolvating nebulizer system was improved by placing its waste gas trap bottle in an ice chamber (5 °C cold trap). This setup, beyond Cr isotope analysis, can be applied to most heavy metal isotope measurements. The sensitivity of the 52Cr signal is ≥300 V mg–1 L (with a 1011Ω amplifier and a 110 μL min–1 uptake rate), an enhancement of ≥1.5 times compared to the Aridus II without the cold trap. In addition, the relative standard deviation of the 52Cr signal varied ≤4% over 8 h, demonstrating high stability. The δ53Cr values of common geological reference materials determined using 10 ng of Cr are in excellent agreement with results measured at 25 ng and 50 ng and are consistent with previous determinations, validating the accurate and precise Cr isotope ratio measurements. An empirical method is proposed to correct for the residual (after subtraction) effect of Fe interference on δ53Cr determination. This method relies on a linear relationship between the [Fe]/[Cr] and δ53Cr shift within one analytical session. Finally, we report the δ53Cr values of 19 new reference materials, ranging from −0.44‰ to 0.49‰. Among them, GSS-7 (−0.44 ± 0.02‰, 2 SD, n = 5), GSS-4 (0.48 ± 0.02‰, 2 SD, n = 5), and GSD-10 (0.49 ± 0.05‰, 2 SD, n = 5) can be used as candidate reference materials for interlaboratory comparisons to complement existing ones that are mostly isotopically unfractionated from the bulk silicate earth.

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Section: Methodsmentioning

confidence: 99%

High-Sensitivity Measurement of Cr Isotopes by Double Spike MC-ICP-MS at the 10 ng Level

Zhu

Wang

et al. 2019

Anal. Chem.

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“…The sample introduction system consists of a computer-controlled ASX-112 (Cetac, Omaha, NE) autosampler and an Aridus II™ (Cetac, Omaha, NE) desolvation unit. As discussed in our lab’s previous report [21], the Aridus II™ setup increases the sensitivity of the SF-ICP-MS by more than 10 times, enabling the measurement of 241 Am at the low level of < 1 pg/L. Samples self-aspirate from the autosampler into the desolvation unit through an Apex perfluoroalkoxy (PFA) 100 μL/minute nebulizer (ESI, Omaha, NE, or equivalent).…”

Section: Methodsmentioning

confidence: 99%

Determination of 241Am in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

Xiao

Saunders

Jones

et al. 2014

J Radioanal Nucl Chem

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Quantification of 241Am in urine at low levels is important for assessment of individuals’ or populations’ accidental, environmental, or terrorism-related internal contamination, but no convenient, precise method has been established to rapidly determine these low levels. Here we report a new analytical method to measure 241Am as developed and validated at the Centers for Disease Control and Prevention (CDC) by means of the selective retention of Am from urine directly on DGA resin, followed by SF-ICP-MS detection. The method provides rapid results with a Limit of Detection (LOD) of 0.22 pg/L (0.028 Bq/L), which is lower than 1/3 of the C/P CDG for 241Am at 5 days post-exposure. The results obtained by this method closely agree with CDC values as measured by Liquid Scintillation Counting, and with National Institute of Standards Technology (NIST) Certified Reference Materials (CRM) target values.

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“…The sample introduction system consists of a computer-controlled ASX-112 (Cetac, Omaha, NE) autosampler and an Aridus II™ (Cetac, Omaha, NE) desolvation unit. The Aridus II™ setup increases the sensitivity of the SF-ICP-MS by >10 times, enabling measurement of 237 Np and 239 Pu at the low level of <1 pg/L [17,29].…”

Section: Instrumentationmentioning

confidence: 99%

Determination of 237Np and 239Pu in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

Xiao

Liu

Jones

2020

J Radioanal Nucl Chem

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Measuring 237 Np and 239 Pu in urine at low levels is important for both biomonitoring and radiological emergency response. Here we report a newly developed and validated analytical method used to determine 237 Np and 239 Pu in urine by selective retention of Np and Pu from 2mL of urine directly onto TEVA® resin followed by SF-ICP-MS (coupled to a membrane desolvating introduction system) detection. The method provides solid phase extraction of Np/Pu with observed recovery ratios ranging from 89% to 113% and rapid results with limits of detection well below recommended detection guidelines for children and pregnant women (NCRP 161 reference).

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Determination of 234U/238U, 235U/238U and 236U/238U isotope ratios in urine using sector field inductively coupled plasma mass spectrometry

Cited by 19 publications

References 18 publications

High-Sensitivity Measurement of Cr Isotopes by Double Spike MC-ICP-MS at the 10 ng Level

High-Sensitivity Measurement of Cr Isotopes by Double Spike MC-ICP-MS at the 10 ng Level

Determination of 241Am in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

Determination of 237Np and 239Pu in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

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