Determination of 46 plasticizers in food contact polyvinyl chloride packaging materials and their migration into food simulants by gas chromatography-mass spectrometry

Abstract

A gas chromatography-mass spectrometry (GC-MS) method was developed for the determination of 46 plasticizers in food contact polyvinyl chloride (PVC) packaging materials and their migration into food simulants, i. e. water, 3% acetic acid, 10% ethanol and olive oil. Plasticizers in the PVC packaging materials, aqueous food simulants and olive oil food simulants were extracted by the dissolution-precipitation, liquid-liquid extraction and gel permeation chromatography (GPC) approaches, respectively. The extracts were analyzed by GC-MS in selective ion monitoring (SIM) mode and quantified using the external standard method. The cal-ibration curves were linear in the ranges of 0.1-2.0 mg/L with the correlation coefficients of 0.9910-0. 999 9. The limits of detection were from 0. 005 mg/kg to 0. 05 mg/kg ( S/N = 5 ). The recoveries at 3 spiked levels were 69.51%-107. 21% and the relative standard deviations (RSDs n = 6) ranged from 3.53% to 18.95%. These results show that this method is fast, sensitive and accurate for the qualitative and quantitative determination of plasticizers in food contact plastic products and 4 types of food simulants.

Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS

“…In the analytical literature, several works regarding the analysis of migrant substances from plastic FCM have been published in recent years. Some of them use screening or non-target approaches for the identification of IAS, NIAS, and unknown migrant substances [7][8][9][10][11][12][13][14], while other published papers deal with the target analysis of selected migrant substances, such as phthalates and plasticizers by gas chromatography (GC) coupled to mass spectrometry (MS) [15][16][17][18]; light stabilizers and antioxidants by liquid chromatography (LC) coupled to ultraviolet-visible spectrophotometry (UV) [19,20], tandem mass spectrometry (MS/MS) [21], and high-resolution mass spectrometry (HRMS) [22]; phenolic compounds, such as 4-nonylphenol by GC-MS [23]; bisphenols, their diglycidyl ethers, and other derivatives by GC-MS [24], LC-UV [25], and LC-HRMS [26]; and primary aromatic amines by GC-MS [27], LC-MS/MS [28], and LC-HRMS [29], among other groups of substances. More information regarding the analytical methods for the target analysis of migrant substances from plastic FCM can be found in several recent review articles published on this topic [4,5,[30][31][32][33].…”

“…Moreover, GC presents the handicap of not being directly compatible with the hydro-ethanolic food simulants of Regulation 10/2011 [1]. For this reason, it is required to use alternative food simulants [17,18,23], such as organic solvents, or to perform a liquid-phase [15,35,36] or a solid-phase extraction [24,27] in order to enable the GC analysis. With regard to the detection technique, currently there are no published methods that use GC coupled to HRMS, which enhances the identification and confirmation confidence of the migrant substances by means of their exact masses.…”

Detecting PAEs in Bottled Water by SPE-LC/QQQ

“…World Health Organization's <guidelines for drinking water quality> provides that the maximum acceptable concentration of Bis 2-ethyl Hexyl Phthalate (DEHP) is 0.008mg/L, and indicates that the detection limit is 1/10-1/50 of this standard [5].GB/T 21911/2008 showed the detection limit of PAEs is no more than 1.5 mg/kg in fatty samples, and 0.05 mg/kg in oil free samples [6]. The detecting instrument was GC-MS, GC and so on [7,8]. There are relatively less references about Liquid Chromatography-Tandem Mass Spectrum (LC/QQQ) [9].…”