Determination of 5-fluorouracil and tegafur in tear fluid of patients treated with oral fluoropyrimidine anticancer agent, S-1

Akune, Yoko; Yamada, Masakazu; Shigeyasu, Chika

doi:10.1007/s10384-018-0603-8

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…For example, the oral administration of minocycline (100 mg) to humans will result in the detection of minocycline in their tear uid 82 . Another example is the reporting of components of an S1 anticancer drug traveling into the tear uid following oral administration 83 . Noninvasive monitoring of drug pharmacokinetics has been demonstrated with skin wipes (i.e., sweat samples), which have been used to accurately re ect drug concentrations in the blood of kidney transplant patients 84 .…”

Section: Chemical Markers Of Exposures In the Tear Fluidmentioning

confidence: 99%

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

Amini,

Okeme

2023

Preprint

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Purpose: Exposures to hazardous chemicals have been linked to many detrimental health effects. It is critical to have effective biomonitoring methods to measure the levels of these chemicals in humans to better evaluate key environmental exposures that increase the risk of chronic disease and death. Traditional biomonitoring utilizing blood and urine is limited due to the specialized skills and invasiveness of collecting these fluid samples. The systematic review focuses on the tear fluid, which is largely under-researched, as promising alternative to these traditional fluids. The objective is to evaluate the practicability of using human tear fluid for biomonitoring environmental exposures, highlighting potential pitfalls and opportunities. Recent finding: Tear fluid biomonitoring represents a promising method for assessing exposures. Tear fluid uniquely interfaces with the external environment at the air-tear interface, providing a surface for airborne chemicals to diffuse into the ocular environment and interact with biomolecules. Tear fluid also contains molecules from the internal environment that have travelled from the blood to tears by crossing the blood-tear barrier. Our review shows that tear fluid can be used to identify hazardous chemicals from the external and environment environments and to differentiate between different exposure groups. Summary: The review provides a critical analysis of the current state of knowledge in tear-based biomonitoring and draws attention to the promise of using the method for noninvasively increasing access to exposure assessment. The method will become acceptable for routine use as more individual and inter lab studies focus on broadly identifying and quantify exposure markers in tears, understanding factors that influence reliability of the method and standardizing the tear fluid method.

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Section: Chemical Markers Of Exposures In the Tear Fluidmentioning

confidence: 99%