Determination of 7-dehydrocholesterol in rat skin and liver by high-performance liquid chromatography

Metabolism of Orally Adiministered Ergosterol and 7-Dehydrocholesterol in Rats and Lack of Evidence for Their Vitamin D Biological Activity.

“…Therefore, the sterols are designated as provitamins D2 and D3, respectively. On the other hand, significant amounts of 7-DHC exist as an intermediate of cholesterol biosynthesis from acetyl CoA in skin of mammals (2,3) and the endogenous 7-DHC can be also coverted into vitamin D3 by UV exposure of the skin in the same manner as in a test tube (4,5) . The vitamin D3 endogenously formed in the skin is absorbed in blood and metabolized to 25 a Significantly different from control (p<0 .01).…”