Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole–linear ion trap in different types of water in Serbia

Petrović, Mira; Škrbić, Biljana; Živančev, Jelena; Ferrando-Climent, Laura; Barceló, Damià

doi:10.1016/j.scitotenv.2013.08.079

Cited by 259 publications

(109 citation statements)

References 42 publications

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“…The occurrence of PPCP and hormones in aquatic ecosystems has been widely studied in many countries (Bendz et al 2005;Camacho-Muñoz et al 2010;Esteban et al 2014;Moldovan 2006;Petrović et al 2014;Ternes 1998;Verlicchi et al 2014;Wang et al 2012). However, these studies are still very limited in Brazil (Caldas et al 2013;de Sousa et al 2014;Jardim et al 2012;Kuster et al 2009;Montagner and Jardim 2011;Sodré et al 2010).…”

Section: Introductionmentioning

confidence: 99%

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Campanha

Awan

Sousa

et al. 2014

Environ Sci Pollut Res

157

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This manuscript reports a 3-year study on occurrence of pharmaceuticals, hormones, and triclosan in surface waters of a central urban region of São Paulo State of Southeast Brazil (the Monjolinho River in São Carlos). Water samples collected once at every 2 months were pre-concentrated by solid-phase extraction (SPE) and analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The most frequently detected compounds in higher concentrations were caffeine, paracetamol, and atenolol (maximum concentrations 129,585, 30,421, and 8199 ng L(-1), respectively), while hormones estrone and 17-β-estradiol were the least detected, in levels up to 14.8 ng L(-1). There was an increasing trend in concentrations of most of the compounds along the river course, especially downstream of the river where there is discharge of both wastewater treatment plant effluent and raw sewage from a particular region of São Carlos city. Concentrations of contaminants were higher during dry periods as a result of decline in the water levels. Decrease in concentrations near the river mouth occurred to different extents for each compound. It was high for caffeine and atenolol, but was very low for carbamazepine and diclofenac. The present study reports the first data about the occurrence of some major emerging contaminants in the Monjolinho River. Besides its regional significance, this work may assist in composing a dataset for water contamination diagnosis focusing on emerging contaminants, both in the Brazilian as well as in the Global studies related to aquatic ecosystems. Such datasets can be helpful for making future public policies on water quality, since these compounds are not yet legally regulated.

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Section: Introductionmentioning

confidence: 99%

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Campanha

Awan

Sousa

et al. 2014

Environ Sci Pollut Res

157

View full text Add to dashboard Cite

show abstract

“…For this reason, in the past century, their detection was infeasible due to lack of sophisticated analytical technique. In recent years, advancements in analytical methods have contributed to the detection of over 100 active agents in pharmaceutical products in different environmental matrices [2,3]. Scientific research studies conducted in Malaysia and worldwide have reported widespread occurrence of pharmaceuticals in surface water, influent and effluent sewage treatment plants and hospitals [4 -7].…”

Section: Introductionmentioning

confidence: 99%

Determination of Prazosin and Simvastatin in Landfill Leachate Using Liquid Chromatography-Time of Flight-Mass Spectrometry

Mussa

Al-Qaim

Abdullah³

et al. 2016

MJAS

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Human pharmaceuticals have been shown to occur in considerably high amounts in sewage treatment plant (STP) effluents and surface waters. So far there is no data available on the occurrence of prazosin and simvastatin in leachate sample in Malaysia. Thus, this study is the first report to analysis of prazosin and simvastatin in leachate samples by using solid phase extractionliquid chromatography-time of flight-mass spectrometry (SPE-LC-TOF-MS). The proposed method included isolation and reconstitute procedure. The linearity range was achieved at 1.5 -3000 μg/L and 0.8 -125 μg/L for prazosin and simvstatin, respectively with a determination coefficient (R 2 ) > 0.99. The limit of quantification (LOQ) for prazosin and simvastatin was calculated at 2.1 and 0.5 ng/L in deionised water (DIW), meanwhile it was recorded at 3.5 and 2.4 ng/L for prazosin and simvastatin in effluent sample, respectively. Two pharmaceutical compounds were detected in the leachate samples: prazosin and simvastatin at concentrations levels of 3850 and 415 ng/L, respectively.Keywords: prazosin, simvastatin, leachate, solid phase extraction, pharmaceutical pollution Abstrak Farmaseutikal manusia telah hadir di dalam effluen loji sisa rawatan dan air permukaan. Sehingga kini, tiada data kajian yang merekodkan kehadiran prazosin dan simvastatin dalam sampel larut lesap di Malaysia. Maka, kajian ini merupakan laporan pertama tentang analisis terhadap prazosin dan simvastatin di dalam sampel larut lesap mengunakan pengekstrakan fasa pepejalkromatografi cecair-masa penerbangan-spekrometri jisim (SPE-LC-TOF-MS). Kaedah yang dibangun meliputi langkah pemisahan dan nilai isian semula. Julat kelinearan dicapai antara 1.5 -3000 μg/L dan 0.8 -125 μg/L masing -masing bagi prazosin dan simvastatin dengan nilai pekali (R 2 ) > 0.99. Had kuantifikasi (LOQ) bagi prazosin and simvastatin dihitung pada aras 2.1 dan 0.5 ng/L di dalam air ternyahion manakala direkod masing-masing pada aras 3.5 dan 2.4 ng/L di dalam sampel efluen. Dua jenis sebatian farmaseutikal ini dikesan in dalam sampel larut lesap pada aras kepekatan masing-masing adalah 3850 and 415 ng/L. Kata kunci: prazosin, simvastatin, larut lesap, pengekstrakan fasa pepejal, pencemaran farmaseutikal

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“…O consumo mundial de fármacos é bastante significativo, um exemplo disso pode ser visto na União Europeia (UE) onde aproximadamente 3.000 diferentes substâncias são usadas em medicamento para consumo humano como analgésicos, anti-inflamatórios, conservantes, antibióticos, -bloqueadores e muitos outros (PETROVIC et al, 2014).…”

Section: Introductionunclassified

“…Desta forma, podem adentrar no ambiente aquático por meio de efluentes de esgoto (DAUGHTON e TERNES, 1999;STUMPF et al, 1999;TERNES et al, 1999;HEBERER, 2002;PETROVIC et al 2003;FENT et al, 2006;CHRISTEN et al, 2010).…”

Section: Introductionunclassified

“…Os diversos estudos possibilitaram que, com o aumento da sensibilidade de equipamentos para a detecção dos PFCPs, mais estudos pudessem ser conduzidos acerca da ocorrência nos diversos meios (KOLPIN et al, 2002;TIXIER et al, 2003;ASHTON et al, 2004) Os PFCPs têm sido encontrados em águas de superfície, solo e até mesmo na água potável na ordem de ng a µg L -1 em todo o mundo HEBERER, 2002;PETROVIC et al, 2003;ALMEIDA e WEBER, 2005;FENT et al, 2006;ELLIS, 2006;BECERRIL, 2009). …”

Section: Introductionunclassified

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Filtros ecológicos: um estudo da remoção de produtos farmacêuticos e de cuidados pessoais e do efeito da contaminação no biofilme

Pompei¹

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Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole–linear ion trap in different types of water in Serbia

Cited by 259 publications

References 42 publications

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Determination of Prazosin and Simvastatin in Landfill Leachate Using Liquid Chromatography-Time of Flight-Mass Spectrometry

Filtros ecológicos: um estudo da remoção de produtos farmacêuticos e de cuidados pessoais e do efeito da contaminação no biofilme

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