Determination of 90Sr traces in medical 90Y after separation on DGA column

Pawlak, Dariusz; Parus, J.; Dziel, Tomasz; Muklanowicz, A.; Mikołajczak, Renata

doi:10.1016/j.talanta.2013.03.081

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…The affinity of the sorbent towards Y 3+ played an important role on its uptake. The nature and number of the specific sorbent sites are involved instantaneously in Y 3+ uptake from the solution [ 16 ]. The chelating Chelex-100 sorbent acts as an active “weak anion-exchanger” towards complex species of Y 3+ such as (YCl 6 ) 3− in HCl media [ 53 ] and “liquid-liquid extraction” with the salt performing as salting-out reagent in Y 3+ uptake.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, huge volumes of radioactive wastes and a diversity of radionuclides are generated from nuclear reaction process are certainly released into the natural environment [13,14]. Tus, many approaches have been described in the last two decades for complete separation of 90 Y 3+ from various solutions via 2-ethylhexyl phosphonic acid mono-2ethylhexyl ester (PC88A) in kerosene, [15], solvent extraction [16][17][18][19][20], organic resin and chelating agent and TBPtreated resins such as amberlite XAD-4 [21][22][23][24], cation ion exchanger [25,26], pyridyl azo napthol (PAN)/zeolite composite [27], Tefon grain support di (2-ethyl hexyl) phosphoric acid-dodecane [28], Chelex-100 [29], paper chromatography [30], nafon-117, and dowex 50W X8 [31]. A 90 Y generator system contained two extraction columns and sec-octylphenoxy acetic acid and tri-n-butyl phosphate as modifer have been used for separation of 90 Y from 90 Sr [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

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Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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There is growing demand for separation of 90Y carrier free from 90Sr coexisting to produce high purity 90Y essential for radiopharmaceutical uses. Thus, in this context the sorption profiles of Y3+ and Sr2+ from aqueous solutions containing diethylenetriaminepenta acetic acid (DTPA), ethylenediaminetetra-acetic acid (EDTA), acetic acid, citric acid, or NaCl onto Chelex-100 (anion ion exchange) solid sorbent were critically studied for developing an efficient and low-cost methodology for selective separation of Y3+ from Sr2+ ions (1.0 × 10−5 M). Batch experiments displayed relative chemical extraction percentage (98 ± 5.4%) of Y3+ from aqueous acetic acid solution onto Chelex-100 (anion ion exchanger), whereas Sr2+ species showed no sorption. Hence, a selective separation of Y3+ from its parent 90Sr2+ has been established based upon percolation of the aqueous solution of Y3+ and Sr2+ ions containing acetic acid at pH 1-2 through Chelex-100 sorbent packed column at a 2 mL min−1 flow rate. Y3+ species were retained quantitatively while Sr2+ ions were not sorbed and passed through the sorbent packed column without extraction. The sorbed Y3+ species were then recovered from the sorbent packed column with HNO3 (1.0 M) at a 1.0 mL min−1 flow rate. A dual extraction mechanism comprising absorption associated to “weak-base anion exchanger” and “solvent extraction” of Y3+ as (YCl6)3− and an extra part for “surface adsorption” of Y3+ by the sorbent is proposed. The established method was validated by measuring the radiochemical (99.2 ± 2 1%), radionuclide purity and retardation factor (Rf = 10.0 ± 0.1 cm) of 90Y3+ recovered in the eluate. Ultimately, the sorbent packed column also presented high stability for reusing 2-3 cycles without drop in its efficiency (±5%) towards Y3+ uptake and relative chemical recovery. A proposed flow sheet describing the analytical procedures for the separation of 90Y3+ from 90Sr2+ using chelating Chelex 100 (anion exchange) packed column is also included.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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“…A new analytical method was developed for the separation of 90 Sr from 90 Y by using DGA resin, in which the extractant system was N,N,N′,N′-tetra-n-octyldiglycolamide (Normal) or N,N,N′,N′-tetrakis-2-ethylhexyldiglycolamide (Branched) [ 52 , 53 ]. The working capacity of the two DGA resins is 7.23 mg Sr and 11 mg yttrium per mL of resin.…”

Section: Sample Preparationmentioning

confidence: 99%

Analytical Methods for the Determination of 90Sr and 239,240Pu in Environmental Samples

Zhong

Yang

et al. 2022

Molecules

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Artificial long-lived radionuclides such as 90Sr and 239,240Pu have been long released into the environment by human nuclear activities, which have a profound impact on the ecological environment. It is of great significance to monitor the concentration of these radionuclides for environmental safety. This paper summarizes and critically discusses the separation and measurement methods for ultra-trace determination of 90Sr, 239Pu, and 240Pu in the environment. After selecting the measurement method, it is necessary to consider the decontamination of the interference from matrix elements and the key elements, and this involves the choice of the separation method. Measurement methods include both radiometric methods and non-radiometric methods. Radiometric methods, including alpha spectroscopy, liquid scintillation spectrometry, etc., are commonly used methods for measuring 239+240Pu and 90Sr. Mass spectrometry, as the representative of non-radiometric measurement methods, has been regarded as the most promising analytical method due to its high absolute sensitivity, low detection limit, and relatively short sample-analysis time. Through the comparison of various measurement methods, the future development trend of radionuclide measurement is prospected in this review. The fully automatic and rapid analysis method is a highlight. The new mass spectrometer with ultra-high sensitivity shows strong analytical capabilities for extremely low concentrations of 90Sr, 239Pu, and 240Pu, and it is expected to develop determination methods with higher sensitivity and lower detection limit.

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“…In order to prove that the 90 Y is suitable for medical application, it is desirable to selectively separate 90 Sr from all possible impurities, including its short‐lived 90 Y daughter. Several separation methods have been reported for the purpose of fast determination of 90 Sr in 90 Y …”

Section: Radiometals For Theranostic Applicationsmentioning

confidence: 99%

“…Several separation methods have been reported for the purpose of fast determination of 90 Sr in 90 Y. [64][65][66] 3.4 | 186/188 Re The chemical similarity between technetium and rhenium has attracted the attention of researchers to design the therapeutic radiopharmaceuticals utilizing the potential of Re radionuclides. 67 The transition metal chemistry of n.c.a.…”

Section: Gamentioning

confidence: 99%

Radiometals for imaging and theranostics, current production, and future perspectives

Mikołajczak

Meulen

Lapi

2019

Labelled Comp Radiopharmac

Self Cite

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The aim of this review is to make the reader familiar with currently available radiometals, their production modes, capacities, and quality concerns related to their medical use, as well as new emerging radiometals and irradiation technologies from the perspective of their diagnostic and theranostic applications. Production methods of 177Lu serve as an example of various issues related to the production yield, specific activity, radionuclidic and chemical purity, and production economy. Other radiometals that are currently used or explored for potential medical applications, with particular focus on their theranostic value, are discussed. Using radiometals for diagnostic imaging and therapy is on the rise. The high demand for radiometals for medical use prompts investigations towards using alternative irradiation reactions, while using existing nuclear reactors and accelerator facilities. This review discusses these production capacities and what is necessary to cover the growing demand for theranostic nuclides.

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Determination of 90Sr traces in medical 90Y after separation on DGA column

Cited by 7 publications

References 4 publications

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Analytical Methods for the Determination of 90Sr and 239,240Pu in Environmental Samples

Radiometals for imaging and theranostics, current production, and future perspectives

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