Structures surrounding the obturator foramen, the obturator internus and obturator externus muscles and regional neurovascular bundle, the obturator artery, vein, and nerve, pass through from the lesser pelvis into the medial compartment of the thigh and build up the obturator region. The region is demanding and complex both in terms of anatomical and clinical points of view. This article aims to write an overview of the obturator region about normal and variant anatomy and relate its various parts to their importance in clinical practice. The connections between various anatomical structures, concerning their different critical sites in the obturator region, as well as a thorough overview essential for clinicians, especially surgeons, are discussed.