Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Abdollahi, Mahbubeh; Hajizadeh, Ebrahim; Baghestani, Ahmad Reza; Haghighat, Shahpar

doi:10.7314/apjcp.2016.17.s3.5

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…As reported by Shaik et al, [13] women within the age group 30-50 are 3.704 more likely to have breast cancer, as found in our case (age group 35-50 years). In close comparison with our findings, age factor and the point of change at diagnosis has been reported at 50 years by Abdollabi et al, [14].…”

Section: Discussionsupporting

confidence: 93%

“…as reported by Shaik et al, [13] within the age group 30-50 are 3.704 more likely to have breast cancer, found in our case (age group 35-50 years). in close comparison with our findings, age factor and point of change at diagnosis has been reported at 50 years by Abdollabi et [14]. However, no study has been made with age at menarche in mind, although this is a high-risk factor in case of breast cancer.…”

Section: Discussionsupporting

confidence: 91%

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Breast Cancer Disease Burden in Albania

Pema

Tarifa

Ikonomi

et al. 2022

AJTES

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Introduction; There are data on an increase in cancer cases in Albania in recent decades, this growing trend of cancer in the Albanian population is due to the rapid increase of habits or unhealthy behaviours such as; smoking, excessive alcohol consumption, unhealthy diet, high levels of obesity, and physical inactivity. However, Albanian men and women show one of the lowest values (in terms of age) in the region of Southeast Europe. In Albania still, we do not have official data regarding the number of breast cancer diagnosed patients either their characteristics, or pathological profile. Our purpose is to conduct retrospective study of number of Breast Cancer patients treated and diagnosed in Albania during 2018. Material and Methods; We have recorded and recorded all breast cancer data from the registry of the Oncology Service at University Hospital Center “Mother Teresa “and private clinics in Tirana and from the registries of the district hospitals, during 2018. Results; Total number of breast cancer patients treated and diagnosed in 2018, from them 506 patients were diagnosed and treated with breast cancer of all stages in our hospital. Since the registry of cancer is still not untirely functioning the data represents only our hospital not. Conclusions; Breast cancer remains a major public health concern worldwide. Trends in the incidence, mortality, and regulated life years of the disabled are varied across regions and countries, suggesting the allocation of appropriate health care resources for breast cancer, which should have the highest level of evaluation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Breast Cancer Disease Burden in Albania

Pema

Tarifa

Ikonomi

et al. 2022

AJTES

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“…On the other hand, our results also showed that patients with an age of ≥55 had a better 3-year overall survival rate. One of the possible explanations for this phenomenon is that young patients were at increased risk of developing more aggressive tumors as the trend found in breast cancer [ 27 , 28 ], thus exhibiting a higher risk of cancer recurrence and death. Other factors analyzed in our multivariate analysis including sex, T stage, the location of the primary tumor or pathological type were not the independent factors for survival outcome.…”

Section: Discussionmentioning

confidence: 99%

Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy

Yang

Chen

et al. 2018

Canadian Journal of Gastroenterology and Hepatology

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Background The prognostic values of weight loss and body mass index (BMI) in esophageal carcinoma remain controversial. This study aimed to evaluate the impacts of weight loss on the survival of patients undergoing radical surgery and adjuvant chemotherapy. Methods The medical records of 189 consecutive patients with nonmetastatic esophageal carcinoma treated in our hospital between January 2012 and December 2013 were reviewed, and 121 patients were included for analysis. Results Kaplan-Meier analysis revealed that the 3-year overall survival rate was significantly higher in the low pretreatment weight loss (pre-LWL) group than in the high pretreatment weight loss (pre-HWL) group (P < 0.001). In addition, the 3-year overall survival rate of normal weight group was higher than that of overweight and underweight groups (P = 0.007). Multivariate Cox proportional hazards analysis showed that pre-LWL group had a significantly better 3-year overall survival than pre-HWL group (P = 0.027, HR = 1.89, and 95% CI = 1.07–3.32). pN stage and age were also the survival prognostic factors. Conclusions Our study showed that low pretreatment weight loss predicted a better survival outcome in the esophageal carcinoma patients with radical surgery and adjuvant chemotherapy. However, BMI and weight loss during treatment had no impact on the survival outcome.

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“…Our results revealed no significant relationship between diagnosis age and breast cancer patients' survival rate or cure probability. However, some studies have reported significant association [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of non-metastatic breast cancer patients by molecular subtypes

et al. 2022

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Background Today, with the progress of medical sciences, increasing the cure probability and survival time is an important goal of cancer treatment. This study compared long-term disease-free survival (DFS) of non-metastatic breast cancer patients based on different molecular subtypes. Methods This retrospective cohort study consisted of 1287 patients diagnosed with breast cancer and treated at Motamed Cancer Institute from 2000 to 2016 and followed up until 2018. Kaplan–Meier curve was fitted to data based on molecular subtypes. Then the semi-parametric mixture cure model was applied to determine the survival and cure probability of molecular subtypes by adjusting clinical and demographic factors. Results Among 1287 breast cancer patients, 200 (15.5%) cases died. The mean age of patients was 47.00 ± 10.72 years. Women with the HR+/HER2-subtype had the best 5-year survival rate (84.2%), whereas other subtypes had a lower rate as follows: HR+/HER2+ (77.3%), triple-negative (76.5%), and HR−/HER2+ (62.3%). Kaplan–Meier curve calculated a cure rate of about 60% and patients who survived more than 150 months were intuitively considered cured. After adjustment for clinical and demographic variables, the cure probability of HR−/Her2+ patients was substantially lower than HR+/HER2– patients (OR = 0.22), though there were no significant variations in short-term DFS based on molecular subtypes (HR = 0.91). Conclusions Our results confirm that the most prevalent breast cancer was HR+/HER2− tumor type which had the best prognosis. It is also concluded that HR−/HER2+ patients had the worst outcomes, with the highest rates of recurrence and metastasis and the lowest overall and disease-free survival rates.

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Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Cited by 6 publications

References 23 publications

Breast Cancer Disease Burden in Albania

Breast Cancer Disease Burden in Albania

Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy

Long-term outcomes of non-metastatic breast cancer patients by molecular subtypes

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