Determination of a Serum-Specific Fraction of Albumin Binding Activity Mediated by a Secretory Phospholipase A2 as a Sepsis-Specific Biomarker

A Rapid Blood Test for Early Detection of Sepsis

“…When using the SFA assay, we found that the SFA activity was completely depleted in the serum samples collected from three patients with sepsis at the time of admission to the ICU [2], and sPLA2 activity was elevated in the sera of these septic patients [1]. We have also studied an additional cohort of septic patients and found that sPLA2 levels and SFA values gradually normalize if patients recover from their illness [5].…”