Determination of aceclofenac in bulk and pharmaceutical formulations

Zawilla, N H; Mohammad, Marah; Kousy, N.M El; Aly, S. M. El-Moghazy

doi:10.1016/s0731-7085(01)00518-0

Cited by 53 publications

(22 citation statements)

References 6 publications

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“…[23][24][25] In this study, from the reaction of bumetanide with p-DAC in an acid medium, a pink compound was formed on the surface of the filter paper, showing a reflectance spectrum with a maximum value of AR Scheme 1 (optical density for reflectance measurements) at 525 nm (Fig. 2).…”

Section: Resultsmentioning

confidence: 92%

An Environmentally Friendly Reflectometric Method for Bumetanide Determination in Pharmaceuticals

et al. 2009

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Section: Resultsmentioning

confidence: 92%

An Environmentally Friendly Reflectometric Method for Bumetanide Determination in Pharmaceuticals

et al. 2009

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“…The reaction between secondary aromatic amines and p-DAC is assumed to take place via the condensation of the protonated secondary amino group with the carbonyl group of the reagent to produce an imminium salt. [32][33][34] The probable mechanism for this reaction is shown in Scheme 1, which is to a large extent based on reactions suggested in the literature. [32][33][34] It is known that micellar media are capable of changing the equilibrium, kinetic and spectral properties of reactions in which they are involved, and this has been used to improve the characteristics of analytical procedures.…”

Section: Resultsmentioning

confidence: 99%

“…[32][33][34] The probable mechanism for this reaction is shown in Scheme 1, which is to a large extent based on reactions suggested in the literature. [32][33][34] It is known that micellar media are capable of changing the equilibrium, kinetic and spectral properties of reactions in which they are involved, and this has been used to improve the characteristics of analytical procedures. 27 The effect of surfactant micelles in the condensation of aldehydes, such as p-DAC, with amines has been subject of a number of publications.…”

Section: Resultsmentioning

confidence: 99%

Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium

et al. 2007

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A sensitive flow-injection (FI) procedure with spectrophotometric detection in a micellar medium is proposed for the determination of novalgin. The method is based on the instantaneous formation of a red-orange product (λmax = 510 nm) after the reaction between novalgin and p-dimethylaminocinnamaldehyde (p-DAC) in a dilute acid medium. The sensitivity of this reaction was increased by a factor of 5.6 in the presence of sodium dodecyl sulfate (SDS). Experimental design methodologies were used to optimize the chemical and FI variables. The calibration curve was linear in the range of 1.45 × 10 -6 to 2.90 × 10 -5 mol L -1 with an excellent correlation coefficient (r = 0.9999). The detection limit was 1.31 × 10 -7 mol L -1 (n = 20, RSD = 2.0%). No interferences were observed from the common excipients. The results obtained by the proposed method were favorably compared with those given by the iodometric reference method at 95% confidence level.

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“…HPTLC [10][11][12][13][14][15][16] HPTLC is the most simple separation technique today available to the analyst.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Estimation of Thiocolchicoside and Aceclofenac by HPTLC

Syal

Kumar

Arora

2017

Int J Curr Pharm Sci

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Objective: Therefore the aim of the present work was to develop simple, precise and accurate HPTLC method for simultaneous determination of THIO and ACE in pharmaceutical dosage form and application of the method for dissolution study with help of HPTLC method. Methods:The TLC procedure was optimized in view to develop a simultaneous assay method for THIO and ACE. HPTLC Pre-coated plates silica gel 60 F254 20×10 cm, layer thickness 0.2 mm (Merck, Germany). The samples were spotted in the form of bands (8 mm) with a Camag 100 microliter sample (Hamilton) syringe on silica gel precoated aluminium 60F254 plates. The mobile phase consisted of methanol: chloroform: water (9.6: 0.2: 0.2 v/v/v) and 10 ml of mobile phase were used per chromatography run. Plates were scanned over the range of 200-400 nm and the spectra were overlain. Results:The detector response was found to be linear in the concentration range of 0.03-0.180 µg/band and 0.75-4.5 µg/band for THIO and ACE and noting the peak areas. Accuracy of the assay method was evaluated with the recovery of the standards from excipients. The mean percentage recoveries obtained for THIO and ACE were 99.34% and 99.08%, respectively, reported. The peak purity of both drugs was assessed by comparing the respective spectra of standard drugs and samples at peak start, peak apex and peak end positions of the spot.Conclusion: HPTLC, with its advantage of low operating cost, high sample thought and minimum sample preparation need is now days preferred as routine analytical techniques for control and assurance. The validated HPTLC method employed here proved to be simple, fast, accurate, precise and sensitive, thus can be used for routine analysis of Thiocolchicoside and Aceclofenac in tablet dosage form.

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Determination of aceclofenac in bulk and pharmaceutical formulations

Cited by 53 publications

References 6 publications

An Environmentally Friendly Reflectometric Method for Bumetanide Determination in Pharmaceuticals

An Environmentally Friendly Reflectometric Method for Bumetanide Determination in Pharmaceuticals

Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium

Simultaneous Estimation of Thiocolchicoside and Aceclofenac by HPTLC

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