Herein, we report the preparation of nanorods‐like Cd(OH)2‐rGO nanocomposites via using a simple co‐precipitation method. The as‐prepared Cd(OH)2‐rGO materials were characterized by a variety of analytical and spectroscopy techniques such as scanning electron microscope (SEM), elemental analysis (EDX), X‐ray diffraction (XRD), and Raman spectroscopy. Interestingly, Cd(OH)2‐rGO modified glassy carbon electrode (GCE) employed for the electrochemical detection of acetaminophen (AP) sensor for first time by using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The AP sensor exhibited an ultra‐high sensitivity of 24.452 µA µM−1 cm−2 and a low detection limit 0.08 µM with wider linear ranges from 0.1 to 102 µM. Notably, the obtained analytical parameters of the AP sensor using nanorods‐like Cd(OH)2‐rGO modified GCE is superior than several rGO based nanocomposites suggesting more suitable for several practical pharmaceutical applications.