Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological, thermal and microscopic methods

Yang, Min; Wang, Peng; Suwardie, Herman; Gogos, Costas G.

doi:10.1016/j.ijpharm.2010.10.026

Cited by 57 publications

(29 citation statements)

References 47 publications

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“…The impact of incorporated low‐molecular weight APIs on a polymer's T g can be found in literature [20–23]. In general, a shift in T g is expected when the API is dissolved into the polymeric excipient, on the other hand the polymer's T g will not change if the two compounds are not in one phase and the API remains crystalline.…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, as observed for the system of INM/PVCap‐PVAc‐PEG in this study, the glass transition temperatures of the mixtures are lower than that of the pure excipient [18, 21, 22, 28] (often referred as plasticization effect). In other cases (often referred as anti‐plasticization effect), the T g of the system may be higher than that of the pure excipient [20, 23] or even higher than both components in the formulation [2, 21, 22]. The last case may occur when the API‐polymer interactions are very strong.…”

Section: Resultsmentioning

confidence: 99%

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Hot melt mixing and foaming of soluplus® and indomethacin

Terife

Wang

Faridi³

et al. 2012

Polymer Engineering & Sci

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The hot melt mixing (HMM) process was used to dissolve 30 wt% of a model drug, indomethacin (INM), in Soluplus® a water soluble polymer excipient. Comprehensive characterization of the HMM‐prepared samples, using differential scanning calorimetry, X‐ray diffraction, Fourier Transform Infrared spectroscopy, and optical microscopy, strongly suggests that INM was in amorphous state, forming a solid solution with the polymer. Furthermore, to understand the impact of foaming on INM's release profile, the HMM product was foamed in a batch process using supercritical carbon dioxide (CO2). Dissolution tests of HMM and reference samples were conducted in aqueous solutions with pH 7.4 and 1.2. In all cases INM's release showed strong pH‐dependency; faster release and a greater amount of INM was released at pH 7.4 than at pH 1.2. For pure INM and the physical mixture, the drug's ionizable character results in the observed pH‐dependency. While for the HMM samples it is also a consequence of theformation of hydrogen bonds between Soluplus® and INM which hinder polymer dissolution at pH 1.2. It was observed that the release rate of INM from different sample types at pH 7.4 decreased in the following sequence: foamed HMM > unfoamed HMM > crystalline INM > physical mixture. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hot melt mixing and foaming of soluplus® and indomethacin

Terife

Wang

Faridi³

et al. 2012

Polymer Engineering & Sci

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“…35 Despite the differences, both methods show similar T g evolution trend with PVC or PEOs content in the blend. The DMA curve of PVC/PEOs blends shows that both relaxations of PVC and PEOs persist, although they shift toward each other, which is characteristic of limited component miscibility (Fig.…”

Section: Ta B L E 4 -Glass Transition Temperatures (T G ) Of Neat Polmentioning

confidence: 89%

“…T g is determined from the peak of the mechanical loss tangent (tanδ) which is responsible for dissipation of energy during deformation, and is defined as: tanδ = E''/E', where E' is the elastic modulus and represents how much energy the polymer stores (storage modulus), and E'' is the viscous modulus and indicates the polymer's ability to dissipate energy as heat (loss modulus). [34][35] The DMA curves for the storage modulus versus temperature (E'/T), and loss modulus versus temperature (E''/T) of neat polymers and PVC/ PEO1 blends are shown in Fig. 3, while the corresponding T gs are summarized in Table 4.…”

Section: Dynamic Mechanical Analysismentioning

confidence: 99%

Miscibility of Poly(Vinyl Chloride) with Poly(Ethylene Oxide) of Different Molecular Weights

Stipanelov¹

2016

Chem.Biochem.Eng.Q.

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In this work, five different techniques: dilute solution viscometry, differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), Fourier transform infrared spectroscopy (FT-IR), and scanning electronic microscopy (SEM) were employed in order to evaluate interactions of amorphous poly(vinyl chloride) (PVC) and semi-crystalline poly(ethylene oxide) (PEO) in solution and solid state. The results varied significantly from one experimental technique to another. The positive interactions between the investigated polymers were found over the whole composition range only in solution. However, in the solid state, by DSC and DMA analysis, the positive interactions were found only at elevated PVC content, while FT-IR and SEM analysis could not confirm interactions between the investigated polymers.

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“…By using the onset of T m , influences of particle size and production of the physical mixtures can be neglected. However, the onset only indicates the starting point of API-dissolution in the polymer without knowing whether the entire fraction of API present in the mixture can be dissolved at that respective temperature [23][24][25]. In contrast, the dissolution endpoint method enables the measurement of the endpoint of the dissolution step and thus might be more accurate.…”

Section: Introductionmentioning

confidence: 99%