Determination of additives in biomer and lycra spandex by pyrolysis tandem mass spectrometry and time temperature resolved pyrolysis mass spectrometry

Richards, Joseph M.; McClennen, William H.; Meuzelaar, Henk L. C.

doi:10.1002/app.1990.070400101

Cited by 17 publications

(2 citation statements)

References 16 publications

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“…The nature of interactions between commercially available PU, that contain additives and/or contaminants, with the host body is not predictable. It has been suggested that these auxiliary chemicals can migrate from the bulk of the polymer to the surface, and subsequently be discharged into the surrounding environment [ 12, [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Commercial polyurethanes: The potential influence of auxiliary chemicals on the biodegradation process

Vermette¹,

Wang²,

Santerre³

et al. 1999

Journal of Biomaterials Science, Polymer Edition

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This investigation elucidates some aspects of auxiliary chemicals on the biodegradation of two commercial polyurethanes (Pellethane and Corethane). The materials were incubated for 28 days with cholesterol esterase and/or with phosphatidylcholine. Extraction studies were carried out on the two materials, using different solvents, chosen on the basis of solvent polarity. FT-IR spectra for the extracted materials indicated the presence of poly(methylene)n oxide moities, silicone oil, bis-ethylene-stearamide, aromatic moities, and alkyd-urea compounds in Pellethane. Corethane materials were shown to contain some fatty acids, hydrocarbon waxes, ester-based species, and chlorinated compounds. Analysis of incubation solutions by high performance liquid chromatography failed to isolate methylene dianiline (MDA) or any of its derivatives from the various polymer incubation solutions. However, a methanol extract of Corethane samples that were incubated for 28 days in cholesterol esterase did show the presence of MDA. The absence of MDA in the Pellethane methanol extracted samples may reflect the differences in surface additives found for this material versus the Corethane. FT-IR/ATR analysis of polymer surfaces exposed to cholesterol esterase/phospholipids mixture showed that there was an increase in the uptake of phospholipids over samples that were incubated in phospholipid dispersion alone. The results of this study show that some of the auxiliary chemicals found in commercial polyurethanes may hinder the specific release of hydrolytic degradation products and delay polymer degradation. However, it should be recognized that the surface layer containing these compounds is susceptible to change following the interaction between the polyurethane-based devices and elements of the host environment (i.e. lipids, enzymes, etc.). Hence, recognition and identification of these changes will ultimately be important in assessing a commercial polymer's blood compatibility characteristics.

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Section: Introductionmentioning

confidence: 99%

Commercial polyurethanes: The potential influence of auxiliary chemicals on the biodegradation process

Vermette¹,

Wang²,

Santerre³

et al. 1999

Journal of Biomaterials Science, Polymer Edition

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“…In particular, the presence of three major additives in different BiomerTM lots [7] has been reported. These additives are: a polysiloxane which may be due to 50 contamination during synthesis of polymer [8]; a high-molecular weight UV stabilizer identified as poly(diisopropylaminomethacrylate-co-decylmethacrylate) (PAM) [9]; and an antioxidant, the 4,4'-butylidene bis(6-t-butyl-m-cresol) [10] known under the commercial name Santowhite Powder (SP).…”

mentioning

confidence: 99%

Effect of toluene extraction on Biomer™ surface: I. ESCA, ATR/FTIR, contact angle analysis and biological properties

Nurdin

François

Magnani

et al. 1996

Journal of Biomaterials Science, Polymer Edition

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Biomer™ is a poly(ether-urethane-urea) block copolymer widely used as biomedical devices. Extraction process of this polymer has purified its surface of low molecular weight polyurethane chains and Santowhite Powder additive. ESCA and ATR/FTIR have suggested a homogenization of the polymer by enrichment of the first layers with poly(aminomethacrylate) additive after extraction. Therefore, the surface of the extracted Biomer™ exhibits a different wettability and biological response. The treatment causes a significant decrease in fibronectin adsorption and induces a reduction in Staphylococcus aureus adhesion.

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Effects of a polymeric additive in a biomedical poly(ether urethaneurea)

Freij-Larsson¹,

Kober²,

Wesslén³

et al. 1993

J of Applied Polymer Sci

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SYNOPSISThe biomedical poly (ether urethaneurea) Biomer has previously been shown to contain a standard antioxidant and a polymethacrylate additive with surface active properties. In the present communication, the latter additive has been shown to influence the morphology, mechanical properties, and surface chemistry of a poly( ether urethaneurea) with a composition similar to Biomer. It was shown that the in uitro blood compatibility of the poly (ether urethaneurea) was improved and that adsorption of fibrinogen from blood plasma decreased significantly due to the presence of the surface active polymethacrylate additive.

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Determination of additives in biomer and lycra spandex by pyrolysis tandem mass spectrometry and time temperature resolved pyrolysis mass spectrometry

Cited by 17 publications

References 16 publications

Commercial polyurethanes: The potential influence of auxiliary chemicals on the biodegradation process

Commercial polyurethanes: The potential influence of auxiliary chemicals on the biodegradation process

Effect of toluene extraction on Biomer™ surface: I. ESCA, ATR/FTIR, contact angle analysis and biological properties

Effects of a polymeric additive in a biomedical poly(ether urethaneurea)

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