Determination of adenine based on the fluorescence recovery of the L-Tryptophan–Cu2+ complex

Facile synthesis of 3D porous nitrogen-doped graphene as an efficient electrocatalyst for adenine sensing

“…Adenine, as an important purine base which exists in DNA, plays a crucial role in the storage of genetic information and protein biosynthesis, and has a widespread effect on coronary and cerebral circulation, energy transduction, enzymatic reactions as cofactors, and even in cell signaling. 1 The accurate determination of adenine in DNA is extremely signicant, because an abnormal change of this purine base is related to a deciency and mutation of the immune system, which may cause various diseases, such as carcinoma, AIDS, epilepsy and Parkinson's disease. In view of this fact, some classical methods including uorescence, 1 high-performance liquid chromatography, 2 liquid chromatography-tandem mass spectrometry, 3 surface-enhanced Raman spectroscopy 4 and electrochemical technique, 5 have been developed for adenine detection.…”

Graphene Oxide Functionalized with 5-Aminophenanthroline for Selective Detection of Adenine through Fluorescence “Turn-Off–On” Response

“…For this reason, standard adenine solution has been used as a baseline to subtract any effect of the free adenine molecule in the system. Finally, in Figure S8 (blue line), the hump at around 260 nm clearly visualized and indicated the in situ GFM-Cu­(II)-adenine complex formation. , …”

“…Finally, in Figure S8 (blue line), the hump at around 260 nm clearly visualized and indicated the in situ GFM-Cu(II)-adenine complex formation. 58,59 Again, the binding constant (BC) 60 value of phenanthroline toward Cu(II) ions is in the order of 10 4 M −1 , but the BC value of adenine and Cu(II) is found to be 100 times less (10 2 M −1 ) in an aqueous medium. The BC value of adenine and GFM-Cu(II) has been calculated using the modified Benesi− Hildebrand equation from the emission intensity values corresponding to 1:1 stoichiometry.…”

Direct Metal-Free Synthesis of Uracil- and Pentaazaphenalene-Functionalized Porous Organic Polymers via Quadruple Mannich Cyclization and Their Nucleobase Recognition Activities

“…Adenine concentration abnormalities in human systems have been linked to AIDS, renal illness, cancer, Parkinson’s disease, and a variety of other disorders that disrupt the metabolic pathways of this molecule. − Consequently, it is critical to develop a speedy and sensitive analytical method for determining and quantifying the concentration of adenine for clinical diagnostic purposes. Surface enhanced Raman spectroscopy (SERS), electrochemical techniques, chemiluminescent immunoassays, high-performance liquid chromatography, capillary electrophoresis, and fluorescence assays are now used to determine adenine. − Although these techniques give better sensitivity and multielement analysis, they are costly, extremely sophisticated, time-consuming to prepare samples, and nonportable. As a result, the development of a simple and accurate analytical method for estimating adenine concentration is critical for the life sciences and bioanalytical chemistry.…”