Determination of Adrenal Response After Oral Administration of Multiple Doses of Methylprednisolone

Garg, Dyal C.; Wagner, John G.; Ayres, James W.; Albert, Kenneth S.

doi:10.1002/j.1552-4604.1979.tb01627.x

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1980

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“…Previ ously, we have reported that the plasma levels of hydrocortisone were reduced to limiting value of 10 ng/ml during 6 days of progressively diminishing therapy with méthylprednisolone tablets; but the plasma hydrocortisone levels began to rise immediately following tire cessa tion of méthylprednisolone administration (2). The degree of suppression in plasma hydrocorti sone levels also depends on the time of day at which the exogenous steroids are administered (3).…”

Section: Introductionmentioning

confidence: 99%

Suppression of Plasma Hydrocortisone Levels

Garg¹,

Weidler²,

Sakmar³

et al. 1980

Pharmacology

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The relative degree of absorption of methylprednisolone acetate when administered by the rectal and oral routes was studied in 12 normal male subjects. The plasma samples were assayed for methylprednisolone and endogenous hydrocortisone concentrations. After the administration of equal doses of methylprednisolone acetate by the rectal and oral routes, the plasma hydrocortisone levels were not significantly different from each other; but the plasma concentrations of methylprednisolone were significantly lower after rectal administration than after oral administration. We conclude that the practice of utilizing the degree of suppression of endogenous hydrocortisone levels as an indicator of the extent of absorption of rectally administered glucocorticoids is inappropriate.

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Section: Introductionmentioning

confidence: 99%