Determination of an Applicable FRAX Model in Korean Women

Lee, Dong Yun; Lim, Seung‐Jae; Moon, Young-Wan; Min, Yong Ki; Choi, DooSeok; Yoon, Byung Koo; Park, Youn Soo

doi:10.3346/jkms.2010.25.11.1657

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…The fracture probabilities of both major osteoporotic fractures and hip fractures significantly increased with age (7,16), but current study showed no significant age difference between the cases and the controls; this comes while in a similar study in Australia (2010), cases were on average five years older than the controls (17).…”

Section: Sexcontrasting

confidence: 74%

“…Two hundred thirty six patients (77 men and 159 women) were enrolled in this study. From among them, 74 patients were Table 2 The predicted probabilities of hip and major fracture in both genders in the three studied models* tries are using a pre-existing model from a surrogate country (7).…”

Section: Resultsmentioning

confidence: 99%

“…In other words, in addition to the clinical risk factors, fracture probability varies greatly based on ethnical differences, and the probability models should be calibrated for each country based on epidemiology of fractures and mortality rates (6). FRAX® models for 31 different countries are available through the web page (http://www.shef.ac.uk/FRAX) (7). Until now there is no report about the accuracy of this tool for fracture prediction in the Iranian population.…”

Section: Schlüsselwörtermentioning

confidence: 99%

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Evaluation of the validity of the FRAX® algorithm for predicting risk of osteoporotic fracture in Iran

Amininezhad¹,

Meybodi²,

Qorbani³

et al. 2015

Osteologie

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SummaryThe present study was designed to determine the most applicable FRAX® model for the Iranian population. Methods: Seventy four men and women (with the mean age of 70 years), who had experienced at least a fragility fracture in their life, along with 162 individuals with no such an experience (with the mean age of 66 years), were enrolled in this study. Fracture probabilities were calculated using FRAX® models from Jordan, Lebanon and the US.We found a significant difference in the probability rate between the fracture cases and the controls; the rate, however, was lower than the recommended threshold for intervention, especially for the Lebanese and the Jordanian models.As for women all the three models had a good discrimination value, while the Lebanese and the Jordanian model needed to be revised. As for men, on the other hand, the Jordanian model had a low discriminative value. The Lebanese model, despite its acceptable discrimination value, needed a revision regarding its threshold. The US model was the most compatible.

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Section: Sexcontrasting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Schlüsselwörtermentioning

confidence: 99%

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Evaluation of the validity of the FRAX® algorithm for predicting risk of osteoporotic fracture in Iran

Amininezhad¹,

Meybodi²,

Qorbani³

et al. 2015

Osteologie

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“…8 Postmenopausal women from the general population were evaluated based on models from Japan, Turkey, and China. 9 The Japan model is suitable for Koreans, but these general population data produced higher scores for fracture probabilities than our data. Previous data on patients with proximal femoral fracture probabilities calculated using the Korean FRAX model produced higher scores than our data because our data involved a general population.…”

Section: Discussioncontrasting

confidence: 50%

Routine Application of the Korean FRAX Model in Women: a Single-center Study

Kim

Lee

Chung

et al. 2012

Korean J Bone Metab

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= Abstract =Objectives: The objective of this study was to assess the efficacy of the Korean fracture-risk assessment tool (FRAX) model for routine application in women who had a general check-up for bone mineral density (BMD). Methods: This retrospective study was conducted at a university hospital and comprised 343 patients, whose BMD and clinical risk factors were assessed for FRAX calculation. The 10-year probabilities of hip and major osteoporotic fractures were compared with the result of the FRAX ® tool (http://www.shef.ac.uk/FRAX, web version 3.5) applied to Korean models developed at the World Health Organization Collaborating Center with or without femoral neck bone mineral density. Results: The T-score gradually decreased with increasing age. Additionally, the 10-year probability of a major osteoporotic fracture increased with age. However, the probability of hip fracture showed no correlation with age if BMD was not included in the estimation. Conclusion: Previous report on patients whose probability of a proximal femoral fracture were calculated using Korean FRAX models produced a higher score than our data because our data involved a general population. A larger general population is needed to confirm the Korean FRAX model. However, our data provide information for physicians to assess the Korean FRAX model in the general female population.

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“…Основная масса исследований по применению FRAX посвящена валидации этой методики в разных странах, сопоставлению данных о вероятности переломов внутри различных социальных, возрастных и других групп [36][37][38], анализу эффективности препаратов для лечения ОП и снижения риска переломов, а также сравнению чувствительности и специфичности метода FRAX и других методик для выявления лиц с ОП и высоким риском переломов [39,40].…”

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