Determination of antibiotics during treatment of hospital wastewater using automated solid-phase extraction followed by UHPLC-MS: occurrence, removal and environmental risks

Mthiyane, Zamazwi Lukhanyiso; Makhubela, Nkosinathi; Nyoni, Hlengilizwe; Madikizela, Lawrence Mzukisi; Maseko, Bethusile Rejoice; Ncube, Somandla

doi:10.1080/09593330.2023.2209741

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…For the analysis and quantification of EPPPs and PhACs in aquatic environments, numerous sophisticated chromatographic and spectroscopic methodologies and instrumentation, such as LC-MS, GC-MS, SPE, HILIC, and HPLC-MS, are commonly employed, which have allowed for the high-throughput monitoring of hundreds of chemicals even at exceedingly low quantities [53,54,[195][196][197][198][199][200][201][202][203][204][205][206][207][208][209][210]. HPLC is widely recognized as the predominant analytical technique in the field.…”

Section: Methods Of Analysis Detecting and Monitoring Of Pharmaceutic...mentioning

confidence: 99%

Insights in Pharmaceutical Pollution: The Prospective Role of eDNA Metabarcoding

Papaioannou,

Geladakis,

Kommata

et al. 2023

Toxics

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Environmental pollution is a growing threat to natural ecosystems and one of the world’s most pressing concerns. The increasing worldwide use of pharmaceuticals has elevated their status as significant emerging contaminants. Pharmaceuticals enter aquatic environments through multiple pathways related to anthropogenic activity. Their high consumption, insufficient waste treatment, and the incapacity of organisms to completely metabolize them contribute to their accumulation in aquatic environments, posing a threat to all life forms. Various analytical methods have been used to quantify pharmaceuticals. Biotechnology advancements based on next-generation sequencing (NGS) techniques, like eDNA metabarcoding, have enabled the development of new methods for assessing and monitoring the ecotoxicological effects of pharmaceuticals. eDNA metabarcoding is a valuable biomonitoring tool for pharmaceutical pollution because it (a) provides an efficient method to assess and predict pollution status, (b) identifies pollution sources, (c) tracks changes in pharmaceutical pollution levels over time, (d) assesses the ecological impact of pharmaceutical pollution, (e) helps prioritize cleanup and mitigation efforts, and (f) offers insights into the diversity and composition of microbial and other bioindicator communities. This review highlights the issue of aquatic pharmaceutical pollution while emphasizing the importance of using modern NGS-based biomonitoring actions to assess its environmental effects more consistently and effectively.

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Section: Methods Of Analysis Detecting and Monitoring Of Pharmaceutic...mentioning

confidence: 99%

Insights in Pharmaceutical Pollution: The Prospective Role of eDNA Metabarcoding

Papaioannou,

Geladakis,

Kommata

et al. 2023

Toxics

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“…Notably, both medicines are difficult to be removed from medical wastewater and of high-value to be isolated for recycling, owing to their broad-spectrum antibacterial activity. [71] The long-term filtration studies were conducted with a feed solution containing equal concentrations of OLA and AZM in methanol. Crossflow filtration was applied to avoid membrane contamination induced by concentration polarization.…”

Section: High-efficiency Biomolecule Cleaning Devicementioning

confidence: 99%

Bioinspired Gradient Covalent Organic Framework Membranes for Ultrafast and Asymmetric Solvent Transport

Zuo,

Lyu,

Yao

et al. 2024

Advanced Materials

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Gradients played a pivotal role in membrane technologies, e.g., osmotic energy conversion, desalination, biomimetic actuation, selective separation and more. In these applications, the compositional gradients are of great relevance for successful function implementation, ranging from solvent separation to smart devices. However, the construction of functional gradient in membranes is still challenging both in scale and directions. Inspired by the specific function‐related, graded porous structures in glomerular filtration membranes, we report here a general approach for constructing gradient covalent organic framework membranes (GCOMx) applying poly (ionic liquid)s as template. With graded distribution of highly porous COF crystals along the membrane, GCOMx exhibited an unprecedented asymmetric solvent transport when applying different membrane sides as the solvent feed surface during filtration, leading to a much‐enhanced flux (10∼18 times) of the “large‐to‐small” pore flow comparing to the reverse direction, verified by hydromechanical theoretical calculations. Upon systematic experiments, GCOMx achieved superior permeance in nonpolar (hexane∼260.45 LMH bar−1) and polar (methanol∼175.93 LMH bar−1) solvents, together with narrow molecular weight cut‐off (MWCO, 472 g mol−1) and molecular weight retention onset (MWRO, <182 g mol−1). Interestingly, GCOMx showed significant filtration performance in simulated kidney dialysis, revealing great potential of GCOMx in bionic applications.This article is protected by copyright. All rights reserved

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“…Several countries have investigated the presence of antibiotics in African waters. Different antibiotics have been detected in Egypt, South Africa, ,,− Kenya, Zambia, and Tunisia . Sulfamethoxazole had been detected in both influent and effluent with the highest concentration of 33 μg L –1 and 30.04 μg L –1 in Zambia, while ciprofloxacin was highest in South Africa with a concentration of 1.3 μg L –1 influent sample and 1.6 μg L –1 in effluent sample, Table S4 …”

Section: Pharmaceuticals Physicochemical Propertiesmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Adsorbents for the Selective Removal of Pharmaceuticals from Wastewater: Adsorption Kinetics, Isotherms, and Thermodynamics Studies

Nxumalo,

Mahlambi

2023

Ind. Eng. Chem. Res.

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The majority of pharmaceuticals are found in the environment as mixtures. However, a significant amount of these therapeutic compounds cannot be completely metabolized by the human body; thus, they are excreted through feces and urine and end up in wastewater treatment plants (WWTPs). The presence of pharmaceuticals and the degree to which they can be removed during wastewater treatment are now important research topics. Despite the adoption of various alternative technologies for the treatment of wastewater, the adsorption process is still regarded as a promising method due to its high efficiency, increased simplicity, and lower costs. Recent developments in the adsorption process involve the incorporation of an artificial molecularly imprinted polymer (MIP), which is a potent molecular receptor capable of selectively recognizing and removing pollutants. The MIP has advantageous characteristics, which include high affinity, predetermination, high stability, ease of preparation, and low cost. Notably, MIPs can be applied to the cleanup and preconcentration of analytes as the selective adsorbent of solid-phase extraction (SPE), magnetic solid phase extraction (MSPE), and dispersive solid-phase extraction (dSPE). Furthermore, MIPs can be produced as composite nanomaterials by employing nanoparticles (nanoMIP). The advancements of MIPs employed as sorbent materials for quantitative assessment and purification of pharmaceuticals in environmental water have been given most of the focus. Therefore, this study not only aims to present the fundamental ideas about the application of MIPs as sorbents but also gives an overview of the considerable initiatives made in recent years to enhance the performance of MIPs. Considering this, various current approaches to the development of MIP-based extraction techniques are detailed in the present review. This review also demonstrates how kinetics, thermodynamics, and isotherm models can be used to better understand the behavior of adsorbents and the adsorption process.

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Determination of antibiotics during treatment of hospital wastewater using automated solid-phase extraction followed by UHPLC-MS: occurrence, removal and environmental risks

Cited by 9 publications

References 53 publications

Insights in Pharmaceutical Pollution: The Prospective Role of eDNA Metabarcoding

Insights in Pharmaceutical Pollution: The Prospective Role of eDNA Metabarcoding

Bioinspired Gradient Covalent Organic Framework Membranes for Ultrafast and Asymmetric Solvent Transport

Molecularly Imprinted Polymer-Based Adsorbents for the Selective Removal of Pharmaceuticals from Wastewater: Adsorption Kinetics, Isotherms, and Thermodynamics Studies

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