Determination of antibiotics in influents and effluents of wastewater-treatment-plants in the Czech Republic – development and application of the SPE and a UHPLC-ToFMS method

Tylová, Tereza; Flieger, Miroslav; Olšovská, Jana

doi:10.1039/c3ay00048f

Cited by 34 publications

(14 citation statements)

References 47 publications

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“…Therefore, the detection of AMP residues in foodstuffs is very important for human health protection. In the past decades, many efforts have been made to develop efficient methods to detect the AMP residues in agricultural products and waters, including immunoassay (Kloth et al 2009), high-performance liquid chromatography-mass spectrometry (Chen et al 2015;Cheng et al 2015;Kipper et al 2011;Meng et al 2015;Straub and Voyksner 1993;Tylova et al 2013), nuclear magnetic resonance (Reinscheid 2006), colorimetry (Khan et al 2015;Xu et al 2004), fluorescence detection (Fernández.González et al 2003;Pena et al 2010), raman spectroscopy (Andreou et al 2015), electrochemiluminescence (Li et al 2011) and dual fluorescence-colorimetric biosensor (Song et al 2012). For example, Ban's group developed an aptasensor to detect AMP using its single-stranded DNA aptamer and gold nanoparticles-based dual fluorescence-colorimetric method (Song et al 2012a).…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy

Wang

Dong

Gai

et al. 2016

Biosensors and Bioelectronics

104

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Section: Introductionmentioning

confidence: 99%

Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy

Wang

Dong

Gai

et al. 2016

Biosensors and Bioelectronics

104

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“…Furthermore, the comparison of other reported SPE methods for the determination of macrolide drugs in water by LC-MS/MS was illustrated in Table 3 . The LODs of the developed MISPE cartridge were lower than those of the SPE methods using Strata-X [ 26 ], Oasis HLB [ 11 , 14 , 17 , 27 ] (except for 0.5 ng/L for AZI), and magnetic SPE (MSPE) [ 10 ]. These results indicated that the MISPE cartridge was efficient in the enrichment of trace amounts of MALs in the water samples.…”

Section: Resultsmentioning

confidence: 99%

Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

Song

Zhou

et al. 2018

Molecules

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With the extensive application of antibiotics in livestock, their contamination of the aquatic environment has received more attention. Molecularly imprinted polymer (MIP), as an eco-friendly and durable solid-phase extraction material, has shown great potential for the separation and enrichment of antibiotics in water. This study aims at developing a practical and economical method based on molecularly imprinted solid phase extraction (MISPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneously detecting ten macrolide drugs in different sources of water samples. The MIP was synthesized by bulk polymerization using tylosin as the template and methacrylic acid as the functional monomer. The MIP exhibited a favorable load-bearing capacity for water (>90 mL), which is more than triple that of non-molecularly imprinted polymers (NIP). The mean recoveries of macrolides at four spiked concentration levels (limit of quantification, 40, 100, and 400 ng/L) were 62.6–100.9%, with intra-day and inter-day relative standard deviations below 12.6%. The limit of detection and limit of quantification were 1.0–15.0 ng/L and 3.0–40.0 ng/L, respectively. Finally, the proposed method was successfully applied to the analysis of real water samples.

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“…The separation was performed using the following mobile buffers: A -200 ml methanol, 310 μl formic acid and milliQ water up to 1 L; and B-950 ml methanol, 310 μl formic acid and milliQ water up to 1L. A procedure described by Tylova et al 2013 andSoeborg et al (2004) was used in this study. The MS analysis was performed in the positive ion mode using the settings described previously (Soeborg et al 2004).…”

Section: Extraction Of Tylosin and Metabolites (Nozal-nalda Et Al 2006)mentioning

confidence: 99%

Distribution, Sorption and Desorption of Tylosin, Chlortetracycline and their Metabolites in Pig Manure

Singh

2016

JAS

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Effects of pH on sorption, desorption and hysteresis of chlortetracycline (CTCs), tylosin (TYL) and their metabolites have been studied in pig manure samples collected from different pig farms. Approximately 36% of the samples analyzed tested positive (concentration > quantitative detection limit) for the antibiotics and metabolite residues. The degree of contamination depended upon the manure’s pH. The acidic TYL-positive manure samples contained TYL-A and TYL-B, while the basic TYL-positive samples contained TYL-A, TYL-ALD and TYL-D. The CTC-positive manure samples contained mostly CTC, ECTC and ACTC at acidic pH, but mostly CTC, ICTC, EICTC and EACTC at basic pH. For acidic and neutral manure samples, the logKDdes values were greater than the KDs values for TYL-B, TYL-A, TYL-ALD, CTC, ACTC, ECTC and EACTC, indicating sorption-desorption hysteresis. TYL-D, ICTC and EICTC did not exhibit sorption-desorption hysteresis. At acidic and neutral pH, the residues remained solid-bound, but an increase in pH decreased hysteresis, resulting in greater leaching and contamination of the environment. Thus, environmental pH may determine the antibiotics and metabolite leaching in freshwater at or away from the site of production. In addition, analysis of the parent antibiotic residues may not provide an accurate assessment of the environmental health.

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Determination of antibiotics in influents and effluents of wastewater-treatment-plants in the Czech Republic – development and application of the SPE and a UHPLC-ToFMS method

Cited by 34 publications

References 47 publications

Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy

Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy

Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

Distribution, Sorption and Desorption of Tylosin, Chlortetracycline and their Metabolites in Pig Manure

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