Determination of antidiabetic compounds from Helicteres isora fruits by oral glucose tolerance test

Chandirasegaran, Govindasami; Elanchezhiyan, C.; Ghosh, Kavisa; Sethupathy, S

doi:10.7324/japs.2016.60227

Cited by 10 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ameliorating insulin resistance is an important strategy in the development of new pharmacological treatment for type 2 diabetes. Previously Chandirasegaran et al [12] reported that BC has ameliorating and anti-diabetic activities in STZ induced diabetic rats. The present work was designed to evaluate the modulatory effects of BC on insulin signaling molecules in skeletal muscles and on the levels of lipid profile and oxidant status in STZ induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

2018

Self Cite

View full text Add to dashboard Cite

The goal of the present study was to evaluate the effect of Berberine chloride (BC) on lipid profile, oxidant status and insulin signaling molecules in Streptozotocin (STZ) induced diabetic rat model. Diabetes was induced in rats by a single dose of intraperitoneal administration of STZ (40 mg/kg b.w). Diabetic rats were treated with BC (50 mg/kg b.w) and glibenclamide (6 mg/kg b.w) for 45 days. BC treated diabetic rats showed significant (p \0.05) decrease in the levels of TC, TG, phospholipids, LDL, VLDL and lipid peroxidation markers such as LOOH and TBARS. An increase in enzymatic antioxidant (SOD, CAT and GPx), non-enzymatic antioxidant (GSH, vitamin C and E) and insulin signaling molecules expression, like Insulin receptor substrate-1 (IRS-1), Protein kinase B (PKB or Akt) and glucose transporter-4 (GLUT-4) were found to be significantly raised in BC treated STZ induced diabetic rats. Thus, the results of the current study demonstrated that BC significantly reversed the abnormal levels of lipids, oxidant status and insulin signaling molecules in the diabetic rat model, which may be contributed to its anti-diabetic and antioxidant activities.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Screw tree (Helicteres isora Linn), locally called Usakneo (Timor Island) or kayu ules in Bahasa is a medicinal herb with bioactive compounds in its fruits, roots and barks [1,2,3]. Based on preclinical research, desk study reveals that screw tree (H. isora) has phytopharmacological activities related to diarrhoea curing and diabetics therapy [1,4,5]. Screw tree is native to Asia and Australia with a wide range distribution.…”

Section: Introductionmentioning

confidence: 99%

Field performance of one-year-old medicinal plant: Screw tree (Helicteres isora Linn.) from stem cuttings in the tropical savanna region

Umroni¹,

Rianawati²,

Pamungkas³

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

The purpose of this study is to assess the field performance of the medicinal plant Screw tree (Helicteres isora Linn.) Family Malvaceae in two home garden environments. The screw tree has been commercialized for the production of Jamu, an Indonesian traditional medicine. On Timor Island, however, this species has not yet been cultivated and is considered a weed. Using the t-student test, we compared and described the growth performance of a vegetatively propagated screw tree in two environments. According to field plantation, screw tree grows well in both home gardens, with a survival rate of 97% and 99% for home garden 1 and 2, respectively. For home garden1 and 2, the Increment growth diameter was 0.1 mm month−1 and 0.2 mm month−1, respectively, and increment height was 1.22 cm month−1 and 0.95 cm month−1. For home garden 1 and 2, the average diameter was 0.4 cm; 0.5 cm (P>0.05, ns) and height was 58 cm; 48 cm (P<0.05). There is no significant difference in diameter, but there is a significant difference in height between home garden 1 and 2. In home garden 1, 26% of the plants have begun to flower, compared to 13% in home garden 2. Farmers may benefit from vegetative propagation due to faster flowering and fruiting. Furthermore, the screw tree is most likely appropriate for agroforestry tree/shrub components.

show abstract

“…At the industrial level, the fruit of kayu ules is imported from India to meet the demand, to meet the need of 4.5 ton/month of kayu ules fruit by the leading local industry in Java (Cunningham et al, 2018). Kayu ules has medicinal benefit that has been identified, several active compounds are contained in the fruits, barks, and stems prominently for diabetic therapy (Chandirasegaran, Elanchezhiyan, Ghosh, & Sethupathy, 2016;Kumar, Sharma, Lemos, & Shriram, 2013). It is also an effective anticancer media from the antioxidant compounds, diarrhea (Gayathri, Srinivasan, & Saroja, 2010;Kumar et al, 2013) and antibacterial activity (Sabale et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Fruit of kayu ules is not the only product that can be used. Stem bark, root and leaves has also been reported to have beneficial compounds that has potential for curing diseases (Chandirasegaran et al, 2016;Jain et al, 2014;Kumar & Singh, 2014).…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF STEM DIAMETER, MEDIA TYPE AND LIGHT INTENSITY ON THE GROWTH OF MEDICINAL PLANT OF SCREW TREE/KAYU ULES (Helicteres isora Linn.)

2021

View full text Add to dashboard Cite

Screw tree (Helicteres isora) is a shrub species (Fam: Malvaceae) with 1.5–4 m in height and with multi-main trunks up to 9–12. In Indonesia, kayu ules has been used as a traditional medicine, known as jamu, and has been commercialized. In order to cultivate this species, vegetative propagation is likely promising compared to the generative propagation since seed viability is low and cannot be stored for longterm. Nevertheless, there is a lack of information on which diameter classes, media types and light intensities would give the best result for vegetative propagation. This research aimed to obtain information on which diameter classes and media that were suitable for kayu ules stem cutting propagation and to what degree the light intensity would be best for the growth of the seedlings of kayu ules. Three diameter classes and four media types were employed in a complete random design under the greenhouse environment. Three months old good quality vegetatively-propagated seedlings were transplanted under two light intensities (under transparent canopy and shading net). The result showed that considering the factor of diameter classes and media in kayu ules stem cutting propagation, it had improved the survival of the stem cutting. Diameter class I was best grown in media type 3 with 46.67 ± 12.2 % of survival rate, diameter class II was best grown in media type 2 with 38.67 ± 11.6 % of survival rate, whereas diameter class III was best grown in media type 4 with 52 ± 6.9 % of survival rate. The transplanted seedlings also grew significantly better under transparent canopy with higher light intensity. The distinctive features of screw tree under shading net were wider leaf area, higher specific leaf area and relative water content but it was lower in above ground dry biomass compared to the kayu ules under transparent canopy.

show abstract

Determination of antidiabetic compounds from Helicteres isora fruits by oral glucose tolerance test

Cited by 10 publications

References 9 publications

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

Field performance of one-year-old medicinal plant: Screw tree (Helicteres isora Linn.) from stem cuttings in the tropical savanna region

EFFECT OF STEM DIAMETER, MEDIA TYPE AND LIGHT INTENSITY ON THE GROWTH OF MEDICINAL PLANT OF SCREW TREE/KAYU ULES (Helicteres isora Linn.)

Contact Info

Product

Resources

About