Determination of Apoptotic Effect of Juglone on Human Bladder Cancer TCC-SUP and RT-4 Cells: An In Vitro Study

Bayram, Dilek; Armağan, İlkay; Özgöçmen, Meltem; Şenol, Nurgül; Calapoğlu, Mustafa

doi:10.1615/jenvironpatholtoxicoloncol.2018025226

Cited by 13 publications

(6 citation statements)

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“…The cytotoxic effect of juglone on human breast cancer cell line MCF-7 is characterized by elevated ROS levels, reduced Bcl-2 expression, increased Bax expression, decreased mitochondrial membrane potential, increased intracellular Ca 2+ concentration, outer mitochondrial-membrane rupture, cytochrome c release, and caspase-3 activation [91]. According to a recent study, juglone significantly inhibits the proliferation and induces the apoptosis of human bladder carcinoma cell lines (TCC-SUB and RT-4) [92].…”

Section: Anticancer Effects Of Juglonementioning

confidence: 99%

Juglone in Oxidative Stress and Cell Signaling

2019

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Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and aging processes. However, being a quinone molecule, juglone could also act as a redox cycling agent and produce reactive oxygen species. Such prooxidant properties of juglone may confer health effects, such as by killing cancer cells. Further, recent studies revealed that juglone influences cell signaling. Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer’s disease. Juglone also activates mitogen-activated protein kinases that could promote cell survival, thereby protecting against conditions such as cardiac injury. This review describes recent advances in the understanding of the effects and roles of juglone in oxidative stress and cell signaling.

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Section: Anticancer Effects Of Juglonementioning

confidence: 99%

Juglone in Oxidative Stress and Cell Signaling

2019

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“…The extracts have also been used in folk medicine for many years for treating cancer. The research conducted thus far has demonstrated the anticancer properties of juglone (Ji et al, 2011 ; Li et al, 2013 ; Fang et al, 2015 ; Delaviz et al, 2017 ; Wu et al, 2017 ; Bayram et al, 2018 ; Bayram et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…The antiproliferative properties of juglone have also been confirmed in other studies on various types of cancer cells in vitro . For example, previous studies have demonstrated a strong dose-dependent and time-dependent influence of juglone on the growth of LS-174T colon adenocarcinoma cells (Li et al, 2013 ) and SGC-790 gastric cancer cells (Ji et al, 2011 ) and on the reduction of viability and inhibition of proliferation of SKOV3 ovarian cancer cells through blocking of cell cycle progression (transition from phase G1 to S) (Fang et al, 2015 ); juglone also strongly affected the inhibition of the proliferation of TCC-SUM and RT-4 bladder cancer cells (Bayram et al, 2018 ), MCF-7 breast cancer cells (Ji et al, 2016 ), and CCL-228-SW colon cancer cells (Bayram et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of juglone on C-32 and COLO 829 melanoma cells in in vitro cultures

Zielińska¹,

Płonka-Czerw²,

Kuśmierz³

2022

bta

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Juglone is an allelopathin secreted by black walnut tree of the Juglandaceae family and is used as an active ingredient in many herbal preparations and as a commercial dye. It is considered as an important phytochemical with wide therapeutic potential. Black walnut extract has long been used in folk medicine to treat various types of cancers. It demonstrates antiviral, antibacterial, antifungal, and antitumor activities. The present study aimed to analyze the effect of juglone on the viability and proliferation of melanoma cells of C-32 (amelanotic melanoma) and COLO 829 (melanotic melanoma) cell lines in vitro and on the mRNA expression of genes encoding the proapoptotic BAX protein and caspase 3 and the gene encoding antiapoptotic BCL2 protein. The results showed a dose-dependent effect of juglone on the viability, proliferation, and death induction in C-32 and COLO 829 melanoma cells and in HFF-1 normal dermal fibroblasts in in vitro cultures, but melanoma cells were more sensitive to juglone. Our findings revealed different mRNA expression patterns for all the studied genes in melanoma and normal cells treated with juglone in in vitro cultures.

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“…Moreover, arbutin markedly elevates p21/ WAF1expression, thereby negatively regulating the cell cycle (114). Juglone is a quinone isolated from the root bark, pericarp, and branch bark of fresh Juglone catalpa and its anticancer activity includes inhibition of proliferation and induction of apoptosis of RT4 and TCCSUP bladder cancer cell lines (115).…”

Section: Quinone Compounds Anthraquinonesmentioning

confidence: 99%

Natural Phytochemicals in Bladder Cancer Prevention and Therapy

Xia

Chen

et al. 2021

Front. Oncol.

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Phytochemicals are natural small-molecule compounds derived from plants that have attracted attention for their anticancer activities. Some phytochemicals have been developed as first-line anticancer drugs, such as paclitaxel and vincristine. In addition, several phytochemicals show good tumor suppression functions in various cancer types. Bladder cancer is a malignant tumor of the urinary system. To date, few specific phytochemicals have been used for bladder cancer therapy, although many have been studied in bladder cancer cells and mouse models. Therefore, it is important to collate and summarize the available information on the role of phytochemicals in the prevention and treatment of bladder cancer. In this review, we summarize the effects of several phytochemicals including flavonoids, steroids, nitrogen compounds, and aromatic substances with anticancer properties and classify the mechanism of action of phytochemicals in bladder cancer. This review will contribute to facilitating the development of new anticancer drugs and strategies for the treatment of bladder cancer using phytochemicals.

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Determination of Apoptotic Effect of Juglone on Human Bladder Cancer TCC-SUP and RT-4 Cells: An In Vitro Study

Cited by 13 publications

References 1 publication

Juglone in Oxidative Stress and Cell Signaling

Juglone in Oxidative Stress and Cell Signaling

Effect of juglone on C-32 and COLO 829 melanoma cells in in vitro cultures

Natural Phytochemicals in Bladder Cancer Prevention and Therapy

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