2018
DOI: 10.1002/bmc.4273
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Determination of armepavine in mouse blood by UPLC‐MS/MS and its application to pharmacokinetic study

Abstract: The purpose of this study was to develop an ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method to determine armepavine in mouse blood. Nuciferine was used as internal standard. Chromatographic separation was performed on a UPLC BEH (2.1 × 50 mm, 1.7 μm) column with a gradient elution of acetonitrile and 10 mmol/L ammonium acetate solution (containing 0.1% formic acid). The quantitative analysis was conducted in multiple reaction monitoring mode with m/z 314.1 → 106.9 for … Show more

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Cited by 19 publications
(8 citation statements)
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“…Liquid chromatography conditions separate isocorynoxeine from the endogenous interfering substances as much as possible from the analyte retention time [29][30][31][32][33][34]. In the investigation of chromatographic conditions, mobile phase systems such as methanol-water, acetonitrile-water, methanol-0.1% formic acid, and acetonitrile-0.1% formic acid were investigated.…”
Section: Resultsmentioning
confidence: 99%
“…Liquid chromatography conditions separate isocorynoxeine from the endogenous interfering substances as much as possible from the analyte retention time [29][30][31][32][33][34]. In the investigation of chromatographic conditions, mobile phase systems such as methanol-water, acetonitrile-water, methanol-0.1% formic acid, and acetonitrile-0.1% formic acid were investigated.…”
Section: Resultsmentioning
confidence: 99%
“…The verification method was established in accordance with the US Food and Drug Administration (FDA) bioanalytical method validation guidelines. Validation projects included selectivity, matrix effects, linearity, precision, accuracy, recovery, and stability [8][9][10][11][12].…”
Section: Methodsmentioning
confidence: 99%
“…The verification method was established in accordance with the US Food and Drug Administration (FDA) bioanalytical method validation guidelines [14][15][16][17][18][19]. Validation projects included selectivity, matrix effects, linearity, precision, accuracy, recovery, and stability [20][21][22][23][24].…”
Section: Reference Solution Preparationmentioning
confidence: 99%