Determination of Association Constants (Ka) from Solution NMR Data

Fielding, Lee A.

doi:10.1016/s0040-4020(00)00492-0

Cited by 825 publications

(591 citation statements)

References 167 publications

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“…) of BAAPy and tegafur were mixed in different ratios and a plot of ∆ against the molar fraction of monomer multiplied by the CIS (Xi × ∆ ) was constructed [23,24].…”

Section: H Nmr Titration Experimentsmentioning

confidence: 99%

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Santos

Hall

Manesiotis

2016

Journal of Chromatography B

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2 Highlights Molecularly Imprinted Polymers for anti-cancer pro-drug tegafur were prepared. Stoichiometric imprinting and a custom-made functional monomer were utilised. High selectivity for tegafur vs. other analytes was demonstrated. Clean extracts and recoveries of up to 96% from aqueous samples were achieved. 3 AbstractMolecularly Imprinted Polymers (MIPs) targeting tegafur, an anti-cancer 5-fluorouracil pro-drug, have been prepared by stoichiometric imprinting using 2,6-bis(acrylamido)pyridine ( The synthesised imprinted polymer was employed in solid-phase extraction of the pro-drug using an optimised protocol that included a simple wash with the porogen used in the preparation of the material.Tegafur recoveries of up to 96% were achieved from aqueous samples and 92% from urine samples spiked with the template and three competing analytes. The results demonstrate the potential of the prepared polymers in the pre-concentration of tegafur from biological samples, which could be an invaluable tool in the monitoring of patient compliance and drug uptake and excretion.

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“…) of BAAPy and tegafur were mixed in different ratios and a plot of ∆ against the molar fraction of monomer multiplied by the CIS (Xi × ∆ ) was constructed [23,24].…”

Section: H Nmr Titration Experimentsmentioning

confidence: 99%

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Santos

Hall

Manesiotis

2016

Journal of Chromatography B

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“…The dimerization constants and the association constant were calculated on the basis of the change of the chemical shift of selected protons following literature methods. 42,43,45 Results and discussion…”

Section: H-nmr Dimerization and Association Experimentsmentioning

confidence: 99%

“…6). To evaluate the type of interaction the method of continuous variation (Job's method) for 1 H-NMR data was used, 45 which suggested a 1/1 stoichiometry for the RutpphzPd-Pyr adduct (see ESI Fig. S7 †).…”

Section: Interactions Between Anthracene and Pyrene With Rutpphzpdmentioning

confidence: 99%

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Supramolecular activation of a molecular photocatalyst

et al. 2014

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“…There are many methods reported for determination of complexation constants. 31,32 They are mainly graphical methods and designed computer program packages. The binding constant between receptors and ions were calculated by 1 H NMR titration data using non-linear curve fitting approach.…”

Section: Synthesismentioning

confidence: 99%

Microwave-assisted synthesis of novel amide based chiral tripodal receptors for recognition of cation and anion sensors

Azizoglu¹,

Kaplan²,

Öztürk³

et al. 2016

Arkivoc

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Five novel amide based chiral tripodal receptors were synthesized under microwave irradiation by reacting nitrilotriacetic acid with chiral amino alcohols in a solvent-free medium with high yields (≥ 90%). The recognition affinities of these tripodal receptors were investigated towards anions and chiral organic ammonium cations using 1 H NMR titration method. The results show that receptor 1 displays more affinity against anions compared with other receptors and the tripodal receptor 4 demonstrated a significant enantiomeric selectivity towards the (R)-naphthylethylammonium perchlorate (ERF 54%).

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Determination of Association Constants (Ka) from Solution NMR Data

Cited by 825 publications

References 167 publications

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Supramolecular activation of a molecular photocatalyst

Microwave-assisted synthesis of novel amide based chiral tripodal receptors for recognition of cation and anion sensors

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