Determination of Barbiturates

Goldbaum, Leo R.

doi:10.1021/ac60070a022

Cited by 144 publications

(17 citation statements)

References 10 publications

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“…Phenobarbitone plasma concentration determination This was carried out by the method of Goldbaum (1952), as modified by Jatlow (1973).…”

Section: Chemical Measurementsmentioning

confidence: 99%

Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

Loga¹,

Curry²,

Lader³

1975

Brit J Clinical Pharma

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1Two studies were carried out on acutely psychotic patients receiving chlorpromazine (100 mg) 8-hourly. 2 In the pilot study on five patients, plasma chlorpromazine concentrations fell over the course of 3 weeks of treatment and parallel changes were noted in the plasma half-life of antipyrine, salivation rate and handwriting length. 3 In the main study involving twelve patients treated for 15 weeks, the above findings were confirmed and were interpreted as indicating that chlorpromazine accelerated its own metabolism by inducing liver microsomal oxidising enzymes. No metabolites of chlorpromazine were detected in plasma. 4 The addition of phenobarbitone (50 mg) 8-hourly for 3 weeks, or orphenadrine (100 mg) 8-hourly for 3 weeks, resulted in a lowering of plasma chlorpromazine concentrations together with a further shortening of plasma antipyrine half-life. 5 Physiological effects of the additional treatments suggested that phenobarbitone lessens the effects of chlorpromazine by lowering body concentrations. However, orphenadrine acts more by virtue of its anticholinergic effects. 6 It was concluded that phenobarbitone and orphenadrine should not be prescribed routinely in patients receiving major tranquillisers. The need for the addition of orphenadrine should be assessed in each individual case.

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“…Phenobarbitone plasma concentration determination This was carried out by the method of Goldbaum (1952), as modified by Jatlow (1973).…”

Section: Chemical Measurementsmentioning

confidence: 99%

Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

Loga¹,

Curry²,

Lader³

1975

Brit J Clinical Pharma

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show abstract

“…Several spectrophotometric methods for the quantitative determination and identification of barbiturates are described in the literature (2-8). Identification methods for barbiturates are described by STEVENSON (2), HELL-DORF (5) and GOLDBAUM (4). VAN HAERINGEN (3) gave a review and a critical examination of several of these methods.…”

Section: The Identification and Determination Of Barbiturates In Serummentioning

confidence: 99%

“…For quantitative determination it appeared that the extraction of acidified serum with a large excess of chloroform and determination of the absorption at 240 πιμ in a buffer solution of pH 10 and at pH 2 gave the most satisfactory results. The method according to GOLDBAUM (4) gives an indication of the type of barbiturate, but does not identify it specifically.…”

Section: The Identification and Determination Of Barbiturates In Serummentioning

confidence: 99%

The Identification and Determination of Barbiturates in Serum

Sinnema¹

1967

Clinical Chemistry and Laboratory Medicine

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“…4 -7 Inasmuch as the victim of barbiturate poisoning usually is IRVING SUNSHINE unconscious, recognition of the cause and severity of the intoxication depends largely on chemical identification and quantification of the compound responsible. Ultraviolet spectrophotometric methods developed by Goldbaum,8 Broughton, 9 Wright and Johns,~ Walker and associates 10 A-50 others now permit rapid, reliable quantitative identification of barbiturate compounds in biologic specimens.…”

Section: W Estem Reserve University School Of Medicine Clevelandmentioning

confidence: 99%

Forensic Medicine

Sunshine

1957

Postgraduate Medicine

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Determination of Barbiturates

Cited by 144 publications

References 10 publications

Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

The Identification and Determination of Barbiturates in Serum

Forensic Medicine

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