Determination of bioactive phenolics in herbal medicines containing Cynara scolymus, Maytenus ilicifolia Mart ex Reiss and Ptychopetalum uncinatum by HPLC-DAD

Sá, Ramon Rodrigues; Matos, Rafael Amorim; Silva, Vagner Cardoso; Caldas, Jamile da Cruz; Sauthier, Maria Celeste da Silva; Santos, Walter Nei Lopes dos; Magalhães, Hemerson Iury Ferreira; Júnior, Aníbal de Freitas Santos

doi:10.1016/j.microc.2017.07.009

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…Among other products, the berries such as cranberry, blackberry, blueberry and raspberry have gained the attention of consumers because of their exceptional polyphenolic content that provides great antioxidant, anti-inflammatory, antiviral and antibacterial activities [3][4][5][6]. In the case of artichoke-based products, widely used in the formulation of dietary supplements, their hypolipidemic activity has been partly attributed to some bioactive polyphenolic agents [7,8]. Furthermore, other vegetal products from grapevines and medicinal herbs are increasingly used as ingredients in nutraceuticals because of their multiple beneficial detox and medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Interaction Liquid Chromatography to Characterize Nutraceuticals and Food Supplements Based on Flavanols and Related Compounds

et al. 2021

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Purified extracts from different types of berries and medicinal plants are increasingly used as raw materials for the production of nutraceuticals and dietary supplements, mainly due to their high content in bioactive substances. This is, for instance, the case of phenolic compounds such as flavonoids, which exhibit a wide range of beneficial properties, including antioxidant, anti-inflammatory, antineoplastic and antimicrobial activities. This paper tackles the characterization of several kinds of nutraceuticals based on hydrophilic interaction liquid chromatography (HILIC) with fluorescence detection (FLD). The study focused on the determination of flavanols and related compounds such as condensed tannins. Analytes were recovered by solvent extraction using methanol:water:hydrochloric acid (70:29:1 v:v:v) as the extraction solvent under sonication for 30 min at 55 °C. Experimental design with response surface methodology was used to optimize the HILIC separation to achieve good resolution of the main components, using acetonitrile:acetic acid (99:1 v/v) (solvent A) and methanol:water:acetic acid, (95:3:2 v/v/v) (solvent B) as the components of the mobile phase. For the assessment of the elution gradient, factors under study were solvent B percentage and gradient time. The best conditions were achieved with 10% solvent B as the initial percentage and 30 min of linear gradient to reach 25% solvent B. Principal component analysis and partial least square-discriminant analysis were used to characterize and compare the compositional features of dietary supplements based on both targeted and non-targeted approaches. Results revealed that the sample distribution relied on the oligomeric nature of descriptors.

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Section: Introductionmentioning

confidence: 99%

Hydrophilic Interaction Liquid Chromatography to Characterize Nutraceuticals and Food Supplements Based on Flavanols and Related Compounds

et al. 2021

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“…Através de cromatografi a líquida, encontrou-se em folhas compostos fenólicos, quercetina, kaempferol, taninos condensados, que reduzem a hipersecreção gástrica, motilidade e esvaziamento gástrico, além de apresentar um efeito hipotensivo (SÁ et al, 2017).…”

Section: Methodsunclassified

XVI Jornada Acadêmica, 1º Encontro Anual de Iniciação Cientifica da UNINGÁ

Pelloso¹,

Romani²

2021

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“…Polifenóis são metabólitos secundários amplamente distribuídos no reino vegetal e atuam como: antioxidantes, quelantes de metais, antimutágenos, anticâncer, Brazilian Journal of Development, Curitiba, v.7, n.4, p. 38780-38794 apr 2021 antifúngicos e antialérgicos (Sá et al, 2017). Vários estudos epidemiológicos estabelecem uma ligação entre a ingestão de compostos fenólicos e a redução do risco de doenças, o que foi atribuído ao poder antioxidante e propriedades anti-inflamatórias destes bioativos.…”

Section: Introductionunclassified

Determinação espectrofotométrica de bioativos fenólicos em manga (mangifera indica l) comercializada em governador Mangabeira-Bahia / Spectrophotometric determination of phenolic bioactives in mango (mangifera indica l) commercialized in governador Mangabeira-Bahia

Sauthier¹,

Silva²,

Miranda³

et al. 2021

BJDV

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RESUMOO artigo Determinação espectrofotométrica de bioativos fenólicos em manga Mangifera Indica L.) comercializada em Governador Mangabeira-Bahia apresenta o resultado do projeto de pesquisa (PIBIC-EM) e descreve a determinação de bioativos fenólicos em manga de diferentes frações e variedades, comercializadas na região de Governador Mangabeira, empregando a espectrofotometria e a quimiometria. Estudos indicam que os polifenóis atuam como antioxidantes na prevenção de doenças cardiovasculares, diabetes tipo II, osteoporose, doenças crônicas e câncer, além de aliviar sintomas como tosse e falta de ar, por regular a função pulmonar. Os resultados para o Teor de Flavonoides Totais (TFC) em mg de QE100g-1DW, variaram de 21±1 a 41±3 e de 46±2 ± 94±2 para a polpa e casca de manga, respectivamente. Os resultados para o Teor de Polifenóis Totais (TPC) variaram de 167±4 a 282 ±2 e de 2013 ± 54 a 2668 ±11 mg de GAE100g-1DW. A ferramenta quimiométrica Análise de Componentes Principais (PCA) possibilitou a discriminação dos dados, relacionando a concentração de fenólicos às diferentes porções das mangas analisadas. Os resultados indicam um alto teor de polifenóis, especialmente nas casacas das amostras analisadas. Assim, há um incentivo do consumo saudável e da bioeconomia regional.

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Determination of bioactive phenolics in herbal medicines containing Cynara scolymus, Maytenus ilicifolia Mart ex Reiss and Ptychopetalum uncinatum by HPLC-DAD

Cited by 17 publications

References 25 publications

Hydrophilic Interaction Liquid Chromatography to Characterize Nutraceuticals and Food Supplements Based on Flavanols and Related Compounds

Hydrophilic Interaction Liquid Chromatography to Characterize Nutraceuticals and Food Supplements Based on Flavanols and Related Compounds

XVI Jornada Acadêmica, 1º Encontro Anual de Iniciação Cientifica da UNINGÁ

Determinação espectrofotométrica de bioativos fenólicos em manga (mangifera indica l) comercializada em governador Mangabeira-Bahia / Spectrophotometric determination of phenolic bioactives in mango (mangifera indica l) commercialized in governador Mangabeira-Bahia

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