Determination of bisphenol diglycidyl ethers in topical dosage forms

Søeborg, Tue; Hansen, Steen Honoré; Halling-Sørensen, Bent

doi:10.1016/j.jpba.2005.07.038

Cited by 16 publications

(10 citation statements)

References 25 publications

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“…The most widely used methods were high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) [18][19][20] or mass detection with ion source of atmospheric pressure chemical ionization (APCI) [21,22] or electrospray ionization (ESI) [23,24,26]. Both Pardo and Zhang have indicted that ESI was more suitable to determine this group of compounds since using ESI, a higher signal to noise and lower LOD values were obtained compared to APCI [25].…”

Section: Introductionmentioning

confidence: 99%

Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS

Zou

Lin

Chen

et al. 2012

Eur Food Res Technol

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A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry with electrospray ionization in the positive mode (UPLC-(ESI) MS/MS) method was developed for the simultaneous determination of 16 bisphenol A diglycidyl ether (BADGE), novolac glycidyl ether (NOGE) and related compounds in canned foods. Three non-commercially available standards bisphenol F (2, 3-dihydroxypropyl) glycidyl ether (BFDGEÁH 2 O), bisphenol F (3-chloro-2-hydroxypropyl) glycidyl ether (BFDGEÁ HCl) and bisphenol F (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether (BFDGEÁH 2 OÁHCl) were synthesized and used for qualitative analysis. Quantification of 13 analytes was carried out in multiple reaction monitoring mode using an external calibration, and the interference of matrixes was reduced by the matrix-matched calibration. The parameters of liquid chromatography and mass spectrometry were optimized to obtain maximum selectivity and sensitivity. The validation data obtained from oil-based and aqueous-based canned food matrixes showed low limit of detection, which ranged from 0.24 to 1.84 ng g -1 , acceptable recovery (62.36-101.77 %) and good repeatability (RSD \10), all indicated this optimized method was suitable for the migration evaluation of BADGE, NOGE and their derivatives from can lacquer into food. Finally, this method was applied to the analysis of these compounds at low levels in diverse commercial canned samples.

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Section: Introductionmentioning

confidence: 99%

Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS

Zou

Lin

Chen

et al. 2012

Eur Food Res Technol

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“…In 2006, Soeborg et al [59] conducted migration experiments of bisphenol compounds from lacquered aluminum tubes using a model cream (cetostearyl alcohol, macrogol cetostearyl ether, paraffin, and water) under accelerated extraction conditions (70°C for up to 120 hours). BFDGE, banned in 2005 (EC regulation [58]), was not found in the extraction medium, but all the BADGE derivatives were (Fig.…”

Section: Metal Containersmentioning

confidence: 99%

“…8 Concentrations of BADGE, BADGE·H 2 o, BADGE·H 2 o·HCl and BADGE·2H 2 o extracted from aqueous cream from 5mL lacquered aluminum tubes for 120 hours at 70°C[59].…”

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confidence: 99%

Containers

2012

Sources of Contamination in Medicinal Products and Medical Devices

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“…Moreover, to overcome matrix effects and recovery problems in quantitation when no labeled standards are available, matrix‐matched calibration is a good approach if blank samples are available. This method was used, for instance, by Søeborg, Hansen, and Halling‐Sorensen (2006) to LC–MS/MS determine BADGE, BFDGE, and their derivatives in cream samples. Finally, it must be mentioned that standard addition is the most appropriate alternative to correct matrix effects and recoveries.…”

Section: Quantificationmentioning

confidence: 99%

Recent advances in mass spectrometry analysis of phenolic endocrine disruptors and related compounds

Gallart-Ayala

Moyano

Galcerán

2009

Mass Spectrometry Reviews

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This article reviews recent literature on current methodologies based on chromatography coupled to mass spectrometry to analyze phenolic compounds with endocrine-disrupting capabilities. For this review we chose alkylphenol ethoxylates, bisphenol A, bisphenol F, and their degradation products and halogenated derivatives, which are considered important environmental contaminants. Additionally, some related compounds such as bisphenol diglycidylethers were included. Growing attention has been paid to the mass spectrometric characterization of these compounds and the instrumentation and strategies used for their quantification and confirmation. The current use of gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) methodologies with different mass spectrometers and ionization and monitoring modes is discussed. Practical aspects with regards to the use of these analytical techniques, such as derivatizing reagents in GC-MS, ion suppression in LC-MS, and the most problematic aspects of quantification, are included in the discussion.

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Determination of bisphenol diglycidyl ethers in topical dosage forms

Cited by 16 publications

References 25 publications

Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS

Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS

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Recent advances in mass spectrometry analysis of phenolic endocrine disruptors and related compounds

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