Determination of bisphenol F diglycidyl ether and related compounds by high‐performance liquid chromatography/mass spectrometry

Differentiation of bisphenol F diglycidyl ether isomers and their derivatives by HPLC-MS and GC-MS—comment on the published data

“…It has to be added that most of the papers devoted to the analysis of BFDGE and its derivatives is focused on the BFDGE, BFDGEx2H 2 O and BFDGEx2HCl, whereas BFGDExH 2 OxHCl was analyzed only occasionally [9,16,32]. It may be due to the lack of respective standards.…”

“…High-pressure liquid chromatography-mass spectrometry (HPLC-MS) has been successfully used for analysis of BFDGE. Some authors have reported not perfect but acceptable separation of isomers [6][7][8][9][10][11], while others in order to provide information about the isomer distribution in the analyzed samples have succeeded in perfect separation of isomers [12][13][14][15][16][17]. However, the identification of the isomers has not been performed.…”

Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS

“…The most widely used methods were high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) [18][19][20] or mass detection with ion source of atmospheric pressure chemical ionization (APCI) [21,22] or electrospray ionization (ESI) [23,24,26]. Both Pardo and Zhang have indicted that ESI was more suitable to determine this group of compounds since using ESI, a higher signal to noise and lower LOD values were obtained compared to APCI [25].…”

Ensuring analytical quality in regulated markets through multivariate, multiway and DoE strategies

“…At first, the following oven temperature program was set: the initial temperature (40 ºC) was held for 2 min; then a 10 ºC min -1 ramp to 175 ºC, which was held for 2 min, followed by a 6 ºC min -1 ramp to 280 ºC, In addition to the five expected peaks (1 to 5 in Figure 4.2.1), other peaks appeared; one of them was identified as an isomer of BFDGE, while another as some phthalate compound, which did not interfere in the analysis of the target compounds. In this sense, the Ensuring Analytical Quality in regulated markets through Chapter 4 multivariate, multiway and DoE strategies  169  chromatographic separation of BFDGE is harder than for the rest of the compounds, because the condensation reaction between phenol and formaldehyde, which may occur both in the orto and the para positions of the phenolic ring, results in the final formation of three isomers of BFDGE [54]. At these operating conditions, peak 5, corresponding to BADGE, appeared almost at 35 min.…”

“…1.2.2.1.1. Natural food contamination or resulting from cultivation or production proceduresMaximum levels for contaminants that may occur naturally or result from cultivation practices or production processes have been established and are regularly reviewed[53,54,55]. The development of sampling and analytical methods for the control of some specific substances, such as mycotoxins in foodstuffs, dioxins, dioxin-like polychlorinated…”