Determination of blood concentration levels of psychotropic medications in Rwandan patients

Hahirwa, Innocent; Charlier, Corinne; Karangwa, Charles; Denooz, Raphaël

doi:10.1179/2295333715y.0000000055

Cited by 1 publication

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References 29 publications

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“…So far in Rwanda, the determination of BCLs of these drugs is not done regardless of the case. However, the need to carry out such activity in Rwanda has been demonstrated (Hahirwa, Charlier, Karangwa & Denooz, 2015a). The required equipment and materials are available, but the lack of suitable analytical techniques is the handicap.…”

Section: Introductionmentioning

confidence: 99%

Transfer of high performance liquid chromatography with diode array detection method for determination in serum of psychotropic drugs

Hahirwa

Charlier

Karangwa

et al. 2017

RWJour

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Background: The relevance of the determination of blood concentration levels of psychotropic drugs has been demonstrated in Rwanda. However, due to the lack of appropriate analytical methods, such activity is not carried out in this country. Objective: The aim of this work was to transfer to a Rwandan laboratory a High Performance Liquid Chromatography based method, applicable for the determination in serum of psychotropic drugs commonly prescribed in Rwanda. Method: Liquid-liquid extraction using prazepam as internal standard was used for sample preparation. Chromatographic separation was performed on a Symmetry C8 analytical column, using acetonitrile and a phosphate buffer as mobile phase. The method was validated with respect to total error concept as decision criterion. Results: The validated method was linear over tested dosing intervals with a coefficient of determination greater than 0.99 for all analytes. The precision was good with RSD between 1.3 and 15.6% and the trueness ranged between 87 and 109%.The accuracy of the method was demonstrated as well. Conclusion: The analytical method allowing a simultaneous determination in serum of several antipsychotropic drugs was successfully validated and thus transferred to the Laboratory of Analysis of Foodstuffs, Drugs, Water and Toxics (Rwanda).

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Section: Introductionmentioning

confidence: 99%

Transfer of high performance liquid chromatography with diode array detection method for determination in serum of psychotropic drugs

Hahirwa

Charlier

Karangwa

et al. 2017

RWJour

View full text Add to dashboard Cite

show abstract

Determination of blood concentration levels of psychotropic medications in Rwandan patients

Abstract: It was therefore concluded that patients under psychotropic treatment in Rwanda are exposed to both the risk of drug ineffectiveness and the risk of toxicity (54%) with only 46% of results within the TRR. Consequently, TDM is needed to optimise psychotropic treatment in Rwandan patients.

Cited by 1 publication

References 29 publications

Transfer of high performance liquid chromatography with diode array detection method for determination in serum of psychotropic drugs

Transfer of high performance liquid chromatography with diode array detection method for determination in serum of psychotropic drugs

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