Determination of cadmium and zinc in Alzheimer's brain tissue using Inductively Coupled Plasma Mass Spectrometry

Panayi, A. E.; Spyrou, N. M.; Iversen, Bent Schack; White, Mark A.; Part, P.

doi:10.1016/s0022-510x(01)00672-4

Cited by 157 publications

(104 citation statements)

References 34 publications

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“…Bulk tissue analysis of the postmortem AD brain has generated inconsistent changes between AD and controls [73][74][75][76][77], which might reflect different anatomic areas examined and different sample preparations (e.g., tissue fixation affects zinc measurement [78]). But analysis of bulk tissue zinc content is likely to miss the most interesting changes to zinc in the AD brain.…”

Section: Zincmentioning

confidence: 99%

Biometals and Their Therapeutic Implications in Alzheimer's Disease

2015

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No disease modifying therapy exists for Alzheimer's disease (AD). The growing burden of this disease to our society necessitates continued investment in drug development. Over the last decade, multiple phase 3 clinical trials testing drugs that were designed to target established disease mechanisms of AD have all failed to benefit patients. There is, therefore, a need for new treatment strategies. Changes to the transition metals, zinc, copper, and iron, in AD impact on the molecular mechanisms of disease, and targeting these metals might be an alternative approach to treat the disease. Here we review how metals feature in molecular mechanisms of AD, and we describe preclinical and clinical data that demonstrate the potential for metal-based drug therapy.

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Section: Zincmentioning

confidence: 99%

Biometals and Their Therapeutic Implications in Alzheimer's Disease

2015

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“…Detection limits in urine are 0.1 µg/sample. Inductively coupled plasma-mass spectroscopy (ICP MS) has been used to determine the concentration of zinc in milk samples and brain tissue (Panayi et al 2002;Patterson et al 1992). Detection limits are 0.06 µg/sample for milk and 10.7 ng/g (for a 150 mg sample) for brain tissue samples.…”

Section: Biological Materialsmentioning

confidence: 99%

“…Detection limits are 0.06 µg/sample for milk and 10.7 ng/g (for a 150 mg sample) for brain tissue samples. Recoveries ranged from 99-111% for brain tissue samples (Panayi et al 2002).…”

Section: Biological Materialsmentioning

confidence: 99%

“…ICP-AES, ICP-MS, and AAS are the most commonly used analytical methods to determine zinc levels in plasma, bone, fingernails, hair, and other biological tissues and body fluids (Alvarado et al 1991;AOAC 1990;Arnaud et al 1991;Fan et al 1991;Folin et al 1991;Langmyhr et al 1979;Luterotti et al 1992;Marks et al 1972;NIOSH 1984aNIOSH , 1994Panayi et al 2002;Patterson et al 1992;Shaw et al 1982;Sohler et al 1976;Szpunar et al 1978;Takagi et al 1988;. These methods generally are sensitive enough to measure background levels in the population and levels at which biological effects occur.…”

Section: Identification Of Data Needsmentioning

confidence: 99%

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Toxicological Profile for Zinc

2002

ATSDR's Toxicological Profiles

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“…Zinc deficiency reduces the leptin secretion [7] and its serum level correlated to Parkinson disease [8]. Zinc acts as a neuromodulator at excitatory synapses and has a considerable role in the stress response, Parkinson and Alzheimer's patients [9,10]. Acute zinc toxicity in a dog following ingestion of a metallic object which resulted in marked hemolytic anemia [11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

Shahraki

Forghani

Mohammadi

et al. 2015

Zahedan J Res Med Sci

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Background:Zn is calcium channels blocker and interferes with biological function of calcium ion, and FSH and LH secretion are dependent on calcium ion. Objectives: The aim of this study was evaluate the effects of supra physiological dose of zinc injection in lateral ventricle (LV) on serum FSH, LH, testosterone, and prolactin (PRL) in male rats. Materials and Methods: This experiment was performed on 30 Wistar-Albino male rats weighing 220 -260 g, which were cannulated in LV. Rats were divided into: sham control (SC), control (V), and test (T) groups, randomly. Test group received 10 µL of artificial cerebra spinal fluid (ACSF) containing 0.06 μmol zinc sulfate, for 20 days. Group V was given the same volume of ACSF, but group SC did not receive any agent at this time. At the end, animals were anesthetized by diethyl ether, sacrificed and blood samples were collected. Serum gonadotropins and prolactin were measured via rat kits and ELISA methods. Testosterone was measured by ordinary methods. Obtained data were analyzed by SPSS-17 software and Kruskal-Wallis, Mann-Whitney and Bonnferoni correction statistical tests. Results were expressed as mean ± SD. Statistical differences were recognized significant at P < 0.05. Results: Our findings showed that serum LH, food and weight gain in group T significantly decreased but prolactin value in this group increased in comparison to those in other groups. Conclusions: We conclude that intraventricular (IV) injection of supra physiological dose of zinc sulfate in IV affected on serum LH, prolactin, food intake, and gain of weight in male rats.

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Determination of cadmium and zinc in Alzheimer's brain tissue using Inductively Coupled Plasma Mass Spectrometry

Cited by 157 publications

References 34 publications

Biometals and Their Therapeutic Implications in Alzheimer's Disease

Biometals and Their Therapeutic Implications in Alzheimer's Disease

Toxicological Profile for Zinc

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

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